| Identification |
|---|
| HMDB Protein ID
| CDBP04765 |
| Secondary Accession Numbers
| Not Available |
| Name
| Eukaryotic translation initiation factor 5B |
| Description
| Not Available |
| Synonyms
|
- Translation initiation factor IF-2
- eIF-5B
|
| Gene Name
| EIF5B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTPase activity |
| Specific Function
| Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 |
| GO Classification
|
| Function |
| gtpase activity |
| nucleoside-triphosphatase activity |
| hydrolase activity, acting on acid anhydrides |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| pyrophosphatase activity |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| catalytic activity |
| hydrolase activity |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q11.2 |
| SNPs
| EIF5B |
| Gene Sequence
|
>3663 bp
ATGGGGAAGAAACAGAAAAACAAGAGCGAAGACAGCACCAAGGATGACATTGATCTTGAT
GCCTTGGCTGCAGAAATAGAAGGAGCTGGTGCTGCCAAAGAACAGGAGCCTCAAAAGTCA
AAAGGGAAAAAGAAAAAAGAGAAAAAAAAGCAGGACTTTGATGAAGATGATATCCTGAAA
GAACTGGAAGAATTGTCTTTGGAAGCTCAAGGCATCAAAGCTGACAGAGAAACTGTTGCA
GTGAAGCCAACAGAAAACAATGAAGAGGAATTCACCTCAAAAGATAAAAAAAAGAAAGGA
CAGAAGGGCAAAAAACAGAGTTTTGATGATAATGATAGCGAAGAATTGGAAGATAAAGAT
TCAAAATCAAAAAAGACTGCAAAACCGAAAGTGGAAATGTACTCTGGGAGTGATGATGAT
GATGATTTTAACAAACTTCCTAAAAAAGCTAAAGGGAAAGCTCAAAAATCAAATAAGAAG
TGGGATGGGTCAGAGGAGGATGAGGATAACAGTAAAAAAATTAAAGAGCGTTCAAGAATA
AATTCTTCTGGTGAAAGTGGTGATGAATCAGATGAATTTTTGCAATCTAGAAAAGGACAG
AAAAAAAATCAGAAAAACAAGCCAGGTCCTAACATAGAAAGTGGGAATGAAGATGATGAC
GCCTCCTTCAAAATTAAGACAGTGGCCCAAAAGAAGGCAGAAAAGAAGGAGCGCGAGAGA
AAAAAGCGAGATGAAGAAAAAGCGAAACTGCGGAAGCTGAAAGAAAAAGAAGAGTTAGAA
ACAGGTAAAAAGGATCAGAGTAAACAAAAGGAATCTCAAAGGAAATTTGAAGAAGAAACT
GTAAAATCCAAAGTGACTGTTGATACTGGAGTAATTCCTGCCTCTGAAGAGAAAGCAGAG
ACTCCCACAGCTGCAGAAGATGACAATGAAGGAGACAAAAAGAAGAAAGATAAGAAGAAA
AAGAAAGGAGAAAAGGAAGAAAAAGAGAAAGAGAAGAAAAAAGGACCTAGCAAAGCCACT
GTTAAAGCTATGCAAGAAGCTCTGGCTAAGCTTAAAGAGGAAGAAGAAAGACAGAAGAGA
GAAGAGGAAGAACGTATAAAACGGCTTGAAGAATTAGAAGCCAAGCGTAAAGAAGAGGAA
CGATTGGAACAAGAAAAAAGAGAAAGGAAAAAGCAAAAAGAAAAAGAAAGAAAAGAACGC
TTGAAAAAAGAAGGGAAACTTTTAACTAAATCCCAGAGAGAAGCCAGAGCCAGAGCCGAA
GCTACTCTTAAACTGCTACAAGCTCAGGGTGTTGAAGTGCCATCAAAAGACTCTTTGCCA
AAGAAGAGGCCAATTTATGAAGATAAAAAGAGGAAAAAAATACCACAGCAGCTAGAAAGT
AAAGAAGTGTCTGAATCAATGGAATTATGTGCTGCTGTAGAAGTTATGGAACAAGGAGTA
CCAGAAAAGGAAGAGACACCACCTCCTGTTGAACCAGAAGAAGAAGAAGATACTGAGGAT
GCTGGATTGGATGATTGGGAAGCTATGGCCAGTGATGAGGAGACAGAAAAAGTAGAAGGA
AACAAAGTTCATATAGAAGTAAAAGAAAACCCTGAAGAGGAGGAGGAGGAGGAAGAAGAG
GAAGAAGAAGATGAAGAAAGTGAAGAAGAGGAGGAAGAGGAGGGAGAAAGTGAAGGCAGT
GAAGGTGATGAGGAAGATGAAAAGGTGTCAGATGAGAAGGATTCAGGGAAGACATTAGAT
AAAAAGCCAAGTAAAGAAATGAGCTCAGATTCTGAATATGACTCTGATGATGATCGGACT
AAAGAAGAAAGGGCTTATGACAAAGCAAAACGGAGGATTGAGAAACGGCGACTTGAACAT
AGTAAAAATGTAAACACCGAAAAGCTAAGAGCCCCTATTATCTGCGTACTTGGGCATGTG
GACACAGGGAAGACAAAAATTCTAGATAAGCTCCGTCACACACATGTACAAGATGGTGAA
GCAGGTGGTATCACACAACAAATTGGGGCCACCAATGTTCCTCTTGAAGCTATTAATGAA
CAGACTAAGATGATTAAAAATTTTGATAGAGAGAATGTACGGATTCCAGGAATGCTAATT
ATTGATACTCCTGGGCATGAATCTTTCAGTAATCTGAGAAATAGAGGAAGCTCTCTTTGT
GACATTGCCATTTTAGTTGTTGATATTATGCATGGTTTGGAGCCCCAGACAATTGAGTCT
ATCAACCTTCTCAAATCTAAAAAATGTCCCTTCATTGTTGCACTCAATAAGATTGATAGG
TTATATGATTGGAAAAAGAGTCCTGACTCTGATGTGGCTGCTACTTTAAAGAAGCAGAAA
AAGAATACAAAAGATGAATTTGAGGAGCGAGCAAAGGCTATTATTGTAGAATTTGCACAG
CAGGGTTTGAATGCTGCTTTGTTTTATGAGAATAAAGATCCCCGCACTTTTGTGTCTTTG
GTACCTACCTCTGCACATACTGGTGATGGCATGGGAAGTCTGATCTACCTTCTTGTAGAG
TTAACTCAGACCATGTTGAGCAAGAGACTTGCACACTGTGAAGAGCTGAGAGCACAGGTG
ATGGAGGTTAAAGCTCTCCCGGGGATGGGCACCACTATAGATGTCATCTTGATCAATGGG
CGTTTGAAGGAAGGAGATACAATCATTGTTCCTGGAGTAGAAGGGCCCATTGTAACTCAG
ATTCGAGGCCTCCTGTTACCTCCTCCTATGAAGGAATTACGAGTGAAGAACCAGTATGAA
AAGCATAAAGAAGTAGAAGCAGCTCAGGGGGTAAAGATTCTTGGAAAAGACCTGGAGAAA
ACATTGGCTGGTTTACCCCTCCTTGTGGCTTATAAAGAAGATGAAATCCCTGTTCTTAAA
GATGAATTGATCCATGAGTTAAAGCAGACACTAAATGCTATCAAATTAGAAGAAAAAGGA
GTCTATGTCCAGGCATCTACACTGGGTTCTTTGGAAGCTCTACTGGAATTTCTGAAAACA
TCAGAAGTGCCCTATGCAGGAATTAACATTGGCCCAGTGCATAAAAAAGATGTTATGAAG
GCTTCAGTGATGTTGGAACATGACCCTCAGTATGCAGTAATTTTGGCCTTCGATGTGAGA
ATTGAACGAGATGCACAAGAAATGGCTGATAGTTTAGGAGTTAGAATTTTTAGTGCAGAA
ATTATTTATCATTTATTTGATGCCTTTACAAAATATAGACAAGACTACAAGAAACAGAAA
CAAGAAGAATTTAAGCACATAGCAGTATTTCCCTGCAAGATAAAAATCCTCCCTCAGTAC
ATTTTTAATTCTCGAGATCCGATAGTGATGGGGGTGACGGTGGAAGCAGGTCAGGTGAAA
CAGGGGACACCCATGTGTGTCCCAAGCAAAAATTTTGTTGACATCGGAATAGTAACAAGT
ATTGAAATAAACCATAAACAAGTGGATGTTGCAAAAAAAGGACAAGAAGTTTGTGTAAAA
ATAGAACCTATCCCTGGTGAGTCACCCAAAATGTTTGGAAGACATTTTGAAGCTACAGAT
ATTCTTGTTAGTAAGATCAGCCGGCAGTCCATTGATGCACTCAAAGACTGGTTCAGAGAT
GAAATGCAGAAGAGTGACTGGCAGCTTATTGTGGAGCTGAAGAAAGTATTTGAAATCATC
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 1220 |
| Molecular Weight
| 138825.9 |
| Theoretical pI
| 5.15 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Eukaryotic translation initiation factor 5B
MGKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILK
ELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKD
SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRI
NSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERER
KKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAE
TPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKR
EEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAE
ATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGV
PEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEE
EEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRT
KEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGE
AGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLC
DIAILVVDIMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQK
KNTKDEFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVE
LTQTMLSKRLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQ
IRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEIPVLK
DELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMK
ASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQK
QEEFKHIAVFPCKIKILPQYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTS
IEINHKQVDVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWFRD
EMQKSDWQLIVELKKVFEII
|
| External Links |
|---|
| GenBank ID Protein
| 84043963 |
| UniProtKB/Swiss-Prot ID
| O60841 |
| UniProtKB/Swiss-Prot Entry Name
| IF2P_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_015904.3 |
| GeneCard ID
| EIF5B |
| GenAtlas ID
| EIF5B |
| HGNC ID
| HGNC:30793 |
| References |
|---|
| General References
| Not Available |