Cannabis Compound Database: Showing Protein Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (CDBP04762)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP04762

Secondary Accession Numbers

Not Available

Name

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

Description

Not Available

Synonyms

AGAP-1
Centaurin-gamma-2
Cnt-g2
GGAP1
GTP-binding and GTPase-activating protein 1

Gene Name

AGAP1

Protein Type

Enzyme

Biological Properties

General Function

Involved in ARF GTPase activator activity

Specific Function

GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system

GO Classification

Component
cell part
intracellular
Function
small gtpase regulator activity
ion binding
cation binding
metal ion binding
purine nucleotide binding
binding
nucleotide binding
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
transition metal ion binding
zinc ion binding
enzyme regulator activity
arf gtpase activator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
biological regulation
regulation of biological process
regulation of metabolic process
regulation of cellular process
signal transduction
regulation of cellular metabolic process
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
regulation of nucleotide metabolic process
regulation of nucleotide catabolic process
regulation of purine nucleotide catabolic process
regulation of gtp catabolic process
regulation of gtpase activity
regulation of ras gtpase activity
regulation of arf gtpase activity
intracellular signal transduction
small gtpase mediated signal transduction

Cellular Location

Cytoplasm

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:2

Locus

2q37

SNPs

AGAP1

Gene Sequence

>2574 bp
ATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTC
GAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCG
GTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATGCCTTCGTGAACAGC
CAGGAATGGACGCTGAGTCGATCTGTCCCGGAGCTCAAAGTGGGAATTGTGGGTAACTTG
GCCAGCGGCAAGTCTGCCCTGGTGCACCGGTACCTGACGGGCACATATGTCCAGGAGGAG
TCTCCGGAAGGTGGCAGGTTCAAGAAAGAGATTGTCGTTGATGGACAGAGCTATCTGCTG
CTGATCAGAGATGAAGGGGGCCCCCCGGAGGCGCAGTTTGCCATGTGGGTGGACGCTGTT
ATATTTGTCTTCAGCTTGGAGGATGAAATAAGTTTCCAGACCGTTTACCACTACTACAGT
CGAATGGCCAACTATCGGAACACGAGCGAGATTCCTCTGGTTCTGGTGGGAACCCAGGAT
GCCATAAGTTCTGCTAACCCGAGGGTCATCGATGACGCCAGGGCGAGGAAGCTCTCCAAC
GACCTGAAACGGTGCACGTACTACGAGACGTGTGCTACATACGGGCTGAATGTGGAGAGG
GTCTTCCAGGACGTTGCCCAGAAGATTGTTGCCACAAGGAAGAAGCAGCAGCTGTCCATA
GGACCCTGCAAGTCGCTACCTAATTCTCCCAGCCATTCCTCCGTCTGTTCCGCGCAGGTG
TCTGCCGTGCACATCAGCCAGACAAGTAATGGAGGTGGGAGTTTAAGCGACTATTCCTCC
TCCGTTCCATCGACTCCCAGCACCAGCCAGAAGGAACTTCGGATCGATGTTCCTCCCACT
GCCAACACGCCCACGCCCGTTCGCAAGCAGTCTAAGCGCCGGTCCAACCTGTTCACCTCT
CGGAAAGGGAGCGACCCAGACAAAGAGAAGAAAGGCCTGGAGAGTCGTGCGGACAGCATT
GGGAGCGGCCGAGCCATCCCAATTAAACAGGGCATGCTGTTGAAGCGAAGTGGCAAATCG
TTGAATAAAGAGTGGAAAAAGAAATATGTCACCCTGTGTGACAATGGCGTGCTGACCTAT
CATCCCAGTTTACATGATTACATGCAGAATGTTCATGGTAAGGAGATTGACCTTCTGAGA
ACCACTGTGAAAGTCCCAGGGAAGAGGCCACCCCGAGCCACGTCAGCCTGCGCACCCATC
TCCAGCCCTAAAACCAATGGCCTATCCAAGGACATGAGCAGTTTACACATCTCACCCAAT
TCAGGGAATGTCACTAGTGCATCTGGGTCTCAGATGGCAAGCGGCATCAGCCTGGTCTCC
TTCAACAGCCGACCCGACGGCATGCACCAGCGCTCCTACTCAGTCTCCAGTGCCGACCAG
TGGAGTGAGGCTACGGTCATTGCAAACTCGGCCATCAGCAGTGACACAGGGCTGGGTGAC
TCCGTATGCTCCAGCCCCAGTATCTCCAGCACCACCAGCCCCAAGCTCGACCCGCCCCCC
TCCCCTCACGCCAACAGAAAGAAGCACCGAAGGAAGAAAAGCACTAGCAACTTCAAAGCC
GACGGCCTGTCCGGCACTGCTGAAGAACAAGAAGAAAATTTTGAGTTTATCATTGTGTCC
CTCACTGGCCAAACATGGCACTTTGAAGCCACGACGTATGAGGAGCGGGACGCCTGGGTC
CAAGCCATCGAGAGCCAGATCCTGGCCAGCCTGCAGTCGTGCGAGAGCAGCAAGAACAAG
TCCCGGCTGACGAGCCAGAGCGAGGCCATGGCCCTGCAGTCGATCCGGAACATGCGCGGG
AACTCCCACTGTGTGGACTGCGAGACCCAGAATCCCAACTGGGCCAGTTTGAACTTGGGA
GCCCTCATGTGCATCGAATGCTCAGGGATCCACCGGAATCTTGGCACCCACCTTTCCCGA
GTCCGATCTCTGGACCTGGATGACTGGCCAGTCGAGCTCATCAAGGTGATGTCATCCATC
GGGAACGAGCTAGCCAACAGCGTCTGGGAAGAGAGCAGCCAGGGGCGGACGAAACCATCG
GTAGACTCCACAAGGGAAGAGAAGGAACGGTGGATCCGTGCCAAGTACGAGCAGAAGCTC
TTCCTGGCCCCGCTGCCCTGCACGGAGCTGTCCCTGGGCCAGCACCTGCTGCGGGCCACC
GCCGACGAGGACCTGCGGACGGCCATCCTGCTGCTGGCACACGGCTCCCGGGACGAGGTG
AACGAGACCTGCGGGGAGGGAGACGGCCGCACGGCGCTGCATCTGGCCTGCCGCAAGGGG
AATGTGGTCCTGGCGCAGCTCCTGATCTGGTACGGAGTGGACGTCACGGCCCGAGATGCC
CACGGGAACACAGCTCTGGCCTACGCCCGGCAGGCCTCCAGCCAGGAGTGCATCGACGTG
CTGCTGCAGTACGGCTGCCCCGACGAGCGCTTCGTGCTCATGGCCACCCCTAACCTGTCC
AGGAGAAACAATAACCGGAACAACAGCAGTGGGAGGGTGCCCACCATCATCTGA

Protein Properties

Number of Residues

857

Molecular Weight

94469.2

Theoretical pI

8.01

Pfam Domain Function

Ank (PF00023 )
PH (PF00169 )
ArfGap (PF01412 )
Miro (PF08477 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1
MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNS
QEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLL
LIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQD
AISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSI
GPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPT
ANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKS
LNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPI
SSPKTNGLSKDMSSLHISPNSGNVTSASGSQMASGISLVSFNSRPDGMHQRSYSVSSADQ
WSEATVIANSAISSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKA
DGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNK
SRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSR
VRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKL
FLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKG
NVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPNLS
RRNNNRNNSSGRVPTII

External Links

GenBank ID Protein

80978930

UniProtKB/Swiss-Prot ID

Q9UPQ3

UniProtKB/Swiss-Prot Entry Name

AGAP1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_001037131.1

GeneCard ID