Showing Protein Killer cell lectin-like receptor subfamily B member 1 (CDBP04751)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 compounds
Identification
HMDB Protein ID CDBP04751
Secondary Accession Numbers Not Available
Name Killer cell lectin-like receptor subfamily B member 1
Description Not Available
Synonyms
  1. C-type lectin domain family 5 member B
  2. CD161 antigen
  3. HNKR-P1a
  4. NKR-P1A
  5. Natural killer cell surface protein P1A
Gene Name KLRB1
Protein Type Receptor
Biological Properties
General Function Involved in binding
Specific Function Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells
GO Classification
Function
binding
Cellular Location
  1. Membrane
  2. Single-pass type II membrane protein (Potential)
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 12p13
SNPs KLRB1
Gene Sequence 
>677 bp
ATGGACCAACAAGCAATATATGCTGAGTTAAACTTACCCACAGACTCAGGCCCAGAAAGT
TCTTCACCTTCATCTCTTCCTCGGGATGTCTGTCAGGGTTCACCTTGGCATCAATTTGCC
CTGAAACTTAGCTGTGCTGGGATTATTCTCCTTGTCTTGGTTGTTACTGGGTTGAGTGTT
TCAGTGACATCCTTAATACAGAAATCATCAATAGAAAAATGCAGTGTGGACATTCAACAG
AGCAGGAATAAAACAACAGAGAGACCGGGTCTCTTAAACTGCCCAATATATTGGCAGCAA
CTCCGAGAGAAATGCTTGTTATTTTCTCACACTGTCAACCCTTGGAATAACAGTCTAGCT
GATTGTTCCACCAAAGAATCCAGCCTGCTGCTTATTCGAGATAAGGATGAATTGATACAC
ACACAGAACCTGATACGTGACAAAGCAATTCTGTTTTGGATTGGATTAAATTTTTCATTA
TCAGAAAAGAACTGGAAGTGGACAAACGGCTCTTTTTTAAATTCTAATGACTTAGAAATT
AGAGGTGATGCTAAAGAAAACAGCTGTATTTCCATCTCACAGACATCTGTGTATTCTGAG
TACTGTAGTACAGAAATCAGATGGATCTGCCAAAAAGAACTAACACCTGTGAGAAATAAA
GTGTATCCTGACTCTTG
Protein Properties
Number of Residues 225
Molecular Weight 25414.6
Theoretical pI 6.25
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["46-66"]
Protein Sequence 
>Killer cell lectin-like receptor subfamily B member 1
MDQQAIYAELNLPTDSGPESSSPSSLPRDVCQGSPWHQFALKLSCAGIILLVLVVTGLSV
SVTSLIQKSSIEKCSVDIQQSRNKTTERPGLLNCPIYWQQLREKCLLFSHTVNPWNNSLA
DCSTKESSLLLIRDKDELIHTQNLIRDKAILFWIGLNFSLSEKNWKWINGSFLNSNDLEI
RGDAKENSCISISQTSVYSEYCSTEIRWICQKELTPVRNKVYPDS
GenBank ID Protein 89941407
UniProtKB/Swiss-Prot ID Q12918
UniProtKB/Swiss-Prot Entry Name KLRB1_HUMAN
PDB IDs Not Available
GenBank Gene ID BC113997
GeneCard ID KLRB1
GenAtlas ID KLRB1
HGNC ID HGNC:6373
References
General References Not Available