| Identification |
|---|
| HMDB Protein ID
| CDBP04749 |
| Secondary Accession Numbers
| Not Available |
| Name
| Paired mesoderm homeobox protein 1 |
| Description
| Not Available |
| Synonyms
|
- Homeobox protein PHOX1
- PRX-1
- Paired-related homeobox protein 1
|
| Gene Name
| PRRX1 |
| Protein Type
| Transcription Factor |
| Biological Properties |
|---|
| General Function
| Involved in DNA binding |
| Specific Function
| Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer |
| GO Classification
|
| Component |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| Function |
| binding |
| transcription regulator activity |
| nucleic acid binding |
| dna binding |
| sequence-specific dna binding |
| sequence-specific dna binding transcription factor activity |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| regulation of transcription |
| regulation of transcription, dna-dependent |
| multicellular organismal process |
| multicellular organismal development |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q24 |
| SNPs
| PRRX1 |
| Gene Sequence
|
>735 bp
ATGACCTCCAGCTACGGGCACGTTCTGGAGCGGCAACCGGCGCTGGGCGGCCGCTTGGAC
AGCCCGGGCAACCTCGACACCCTGCAGGCGAAAAAGAACTTCTCCGTCAGTCACCTGCTA
GACCTGGAGGAAGCCGGGGACATGGTGGCGGCACAGGCGGATGAGAACGTGGGCGAGGCT
GGCCGGAGCCTGCTGGAGTCGCCGGGACTCACCAGCGGCAGCGACACCCCGCAGCAGGAC
AATGACCAGCTGAACTCAGAAGAAAAAAAGAAGAGAAAGCAGCGAAGGAATAGGACAACC
TTCAATAGCAGCCAGCTGCAGGCTTTGGAGCGTGTCTTTGAGCGGACACACTATCCTGAT
GCTTTTGTGCGAGAAGACCTTGCCCGCCGGGTGAACCTCACCGAGGCGAGAGTGCAGGTG
TGGTTTCAGAACCGAAGAGCCAAGTTCCGCAGGAATGAGAGAGCCATGCTAGCCAATAAA
AACGCTTCCCTCCTCAAATCCTACTCAGGAGACGTGACTGCTGTGGAGCAGCCCATCGTA
CCTCGTCCTGCTCCGAGACCCACCGATTATCTCTCCTGGGGGACAGCGTCTCCGTACAGC
GCCATGGCTACTTATTCTGCCACATGTGCCAACAATAGCCCTGCACAGGGCATCAACATG
GCCAACAGCATTGCCAACCTGAGACTGAAGGCCAAGGAATATAGTTTACAGAGGAACCAG
GTGCCAACAGTCAAC
|
| Protein Properties |
|---|
| Number of Residues
| 245 |
| Molecular Weight
| 27296.2 |
| Theoretical pI
| 9.91 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Paired mesoderm homeobox protein 1
MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEEAGDMVAAQADENVGEA
GRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPD
AFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPIV
PRPAPRPTDYLSWGTASPYSAMATYSATCANNSPAQGINMANSIANLRLKAKEYSLQRNQ
VPTVN
|
| External Links |
|---|
| GenBank ID Protein
| 197692627 |
| UniProtKB/Swiss-Prot ID
| P54821 |
| UniProtKB/Swiss-Prot Entry Name
| PRRX1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB451463 |
| GeneCard ID
| PRRX1 |
| GenAtlas ID
| PRRX1 |
| HGNC ID
| HGNC:9142 |
| References |
|---|
| General References
| Not Available |