| Identification |
|---|
| HMDB Protein ID
| CDBP04742 |
| Secondary Accession Numbers
| Not Available |
| Name
| Fibroblast growth factor-binding protein 1 |
| Description
| Not Available |
| Synonyms
|
- 17 kDa HBGF-binding protein
- 17 kDa heparin-binding growth factor-binding protein
- FGF-BP
- FGF-BP1
- FGF-binding protein 1
- FGFBP-1
- HBp17
|
| Gene Name
| FGFBP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in heparin binding |
| Specific Function
| Acts as a carrier protein that release fibroblast- binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cell membrane
- Peripheral membrane protein
- Secreted
- extracellular space
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4p15.32 |
| SNPs
| FGFBP1 |
| Gene Sequence
|
>705 bp
ATGAAGATCTGTAGCCTCACCCTGCTCTCCTTCCTCCTACTGGCTGCTCAGGTGCTCCTG
GTGGAGGGGAAAAAAAAAGTGAAGAATGGACTTCACAGCAAAGTGGTCTCAGAACAAAAG
GACACTCTGGGCAACACCCAGATTAAGCAGAAAAGCAGGCCCGGGAACAAAGGCAAGTTT
GTCACCAAAGACCAAGCCAACTGCAGATGGGCTGCTACTGAGCAGGAGGAGGGCATCTCT
CTCAAGGTTGAGTGCACTCAATTGGACCATGAATTTTCCTGTGTCTTTGCTGGCAATCCA
ACCTCATGCCTAAAGCTCAAGGATGAGAGAGTCTATTGGAAACAAGTTGCCCGGAATCTG
CGCTCACAGAAAGACATCTGTAGATATTCCAAGACAGCTGTGAAAACCAGAGTGTGCAGA
AAGGATTTTCCAGAATCCAGTCTTAAGCTAGTCAGCTCCACTCTATTTGGGAACACAAAG
CCCAGGAAGGAGAAAACAGAGATGTCCCCCAGGGAGCACATCAAGGGCAAAGAGACCACC
CCCTCTAGCCTAGCAGTGACCCAGACCATGGCCACCAAAGCTCCCGAGTGTGTGGAGGAC
CCAGATATGGCAAACCAGAGGAAGACTGCCCTGGAGTTCTGTGGAGAGACTTGGAGCTCT
CTCTGCACATTCTTCCTCAGCATAGTGCAGGACACGTCATGCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 234 |
| Molecular Weight
| 26264.1 |
| Theoretical pI
| 9.56 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Fibroblast growth factor-binding protein 1
MKICSLTLLSFLLLAAQVLLVEGKKKVKNGLHSKVVSEQKDTLGNTQIKQKSRPGNKGKF
VTKDQANCRWAATEQEEGISLKVECTQLDHEFSCVFAGNPTSCLKLKDERVYWKQVARNL
RSQKDICRYSKTAVKTRVCRKDFPESSLKLVSSTLFGNTKPRKEKTEMSPREHIKGKETT
PSSLAVTQTMATKAPECVEDPDMANQRKTALEFCGETWSSLCTFFLSIVQDTSC
|
| External Links |
|---|
| GenBank ID Protein
| 5070624 |
| UniProtKB/Swiss-Prot ID
| Q14512 |
| UniProtKB/Swiss-Prot Entry Name
| FGFP1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF149412 |
| GeneCard ID
| FGFBP1 |
| GenAtlas ID
| FGFBP1 |
| HGNC ID
| HGNC:19695 |
| References |
|---|
| General References
| Not Available |