| Identification |
|---|
| HMDB Protein ID
| CDBP04736 |
| Secondary Accession Numbers
| Not Available |
| Name
| Azurocidin |
| Description
| Not Available |
| Synonyms
|
- Cationic antimicrobial protein CAP37
- HBP
- Heparin-binding protein
|
| Gene Name
| AZU1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in serine-type endopeptidase activity |
| Specific Function
| This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram- negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G |
| GO Classification
|
| Function |
| catalytic activity |
| hydrolase activity |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| endopeptidase activity |
| serine-type endopeptidase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| protein metabolic process |
| proteolysis |
|
| Cellular Location
|
- Cytoplasmic granule
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19p13.3 |
| SNPs
| AZU1 |
| Gene Sequence
|
>756 bp
ATGACCCGGCTGACAGTCCTGGCCCTGCTGGCTGGTCTGCTGGCGTCCTCGAGGGCCGGC
TCCAGCCCCCTTTTGGACATCGTTGGCGGCCGGAAGGCGAGGCCCCGCCAGTTCCCGTTC
CTGGCCTCCATTCAGAATCAAGGCAGGCACTTCTGCGGGGGTGCCCTGATCCATGCCCGC
TTCGTGATGACCGCGGCCAGCTGCTTCCAAAGCCAGAACCCCGGGGTTAGCACCGTGGTG
CTGGGTGCCTATGACCTGAGGCGGCGGGAGAGGCAGTCCCGCCAGACGTTTTCCATCAGC
AGCATGAGCGAGAATGGCTACGACCCCCAGCAGAACCTGAACGACCTGATGCTGCTTCAG
CTGGACCGTGAGGCCAACCTCACCAGCAGCGTGACGATACTGCCACTGCCTCTGCAGAAC
GCCACGGTGGAAGCCGGCACCAGATGCCAGGTGGCCGGCTGGGGGAGCCAGCGCAGTGGG
GGGCGTCTCTCCCGTTTTCCCAGGTTTGTCAACGTGACTGTGACCCCCGAGGACCAGTGT
CGCCCCAACAACGTGTGCACCGGTGTGCTCACCCGCCGCGGTGGCATCTGCAATGGGGAC
GGGGGCACCCCCCTCGTCTGCGAGGGCCTGGCCCACGGCGTGGCCTCCTTTTCCCTGGGG
CCCTGTGGCCGAGGCCCTGACTTCTTCACCCGAGTGGCGCTCTTCCGAGACTGGATCGAT
GGTGTTCTCAACAACCCGGGACCGGGGCCAGCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 251 |
| Molecular Weight
| 26885.4 |
| Theoretical pI
| 9.65 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Azurocidin
MTRLTVLALLAGLLASSRAGSSPLLDIVGGRKARPRQFPFLASIQNQGRHFCGGALIHAR
FVMTAASCFQSQNPGVSTVVLGAYDLRRRERQSRQTFSISSMSENGYDPQQNLNDLMLLQ
LDREANLTSSVTILPLPLQNATVEAGTRCQVAGWGSQRSGGRLSRFPRFVNVTVTPEDQC
RPNNVCTGVLTRRGGICNGDGGTPLVCEGLAHGVASFSLGPCGRGPDFFTRVALFRDWID
GVLNNPGPGPA
|
| External Links |
|---|
| GenBank ID Protein
| 11342670 |
| UniProtKB/Swiss-Prot ID
| P20160 |
| UniProtKB/Swiss-Prot Entry Name
| CAP7_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_001700.3 |
| GeneCard ID
| AZU1 |
| GenAtlas ID
| AZU1 |
| HGNC ID
| HGNC:913 |
| References |
|---|
| General References
| Not Available |