| Identification |
|---|
| HMDB Protein ID
| CDBP04719 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ornithine decarboxylase antizyme 1 |
| Description
| Not Available |
| Synonyms
|
- ODC-Az
|
| Gene Name
| OAZ1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in enzyme inhibitor activity |
| Specific Function
| Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 |
| GO Classification
|
| Function |
| enzyme regulator activity |
| enzyme inhibitor activity |
| ornithine decarboxylase inhibitor activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19p13.3 |
| SNPs
| OAZ1 |
| Gene Sequence
|
>696 bp
ATGGTGAAATCCTCCCTGCAGCGGATCCTCAATAGCCACTGCTTCGCCAGAGAGAAGGAA
GGGGATAAACCCAGCGCCACCATCCACGCCAGCCGCACCATGCCGCTCCTAAGCCTGCAC
AGCCGCGGCGGCAGCAGCAGTGAGAGTTCCAGGGTCTCCCTCCACTGCTGTAGTAACCCG
GGTCCGGGGCCTCGGTGGTGCTCTGATGCCCCTCACCCACCCCTGAAGATCCCAGGTGGG
CGAGGGAATAGTCAGAGGGATCACAATCTTTCAGCTAACTTATTCTACTCCGATGATCGG
CTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTCCAGTCC
AGGCTCACAGACGCCAAACGCATTAACTGGCGAACAGTGCTGAGTGGCGGCAGCCTCTAC
ATCGAGATCCCGGGCGGCGCGCTGCCCGAGGGGAGCAAGGACAGCTTTGCAGTTCTCCTG
GAGTTCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAGAACCGC
GAGGACAGAGCCGCCTTGCTCCGAACCTTCAGCTTTTTGGGCTTTGAGATTGTGAGACCG
GGGCATCCCCTTGTCCCCAAGAGACCCGACGCTTGCTTCATGGCCTACACGTTCGAGAGA
GAGTCTTCGGGAGAGGAGGAGGAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 228 |
| Molecular Weight
| 25405.3 |
| Theoretical pI
| 7.57 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ornithine decarboxylase antizyme 1
MVKSSLQRILNSHCFAREKEGDKPSATIHASRTMPLLSLHSRGGSSSESSRVSLHCCSNP
GPGPRWCSDAPHPPLKIPGGRGNSQRDHNLSANLFYSDDRLNVTEELTSNDKTRILNVQS
RLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSFAVLLEFAEEQLRADHVFICFHKNR
EDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMAYTFERESSGEEEE
|
| External Links |
|---|
| GenBank ID Protein
| 57790284 |
| UniProtKB/Swiss-Prot ID
| P54368 |
| UniProtKB/Swiss-Prot Entry Name
| OAZ1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY865622 |
| GeneCard ID
| OAZ1 |
| GenAtlas ID
| OAZ1 |
| HGNC ID
| HGNC:8095 |
| References |
|---|
| General References
| Not Available |