| Identification |
|---|
| HMDB Protein ID
| CDBP04711 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phospholysine phosphohistidine inorganic pyrophosphate phosphatase |
| Description
| Not Available |
| Synonyms
|
- hLHPP
|
| Gene Name
| LHPP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity).
|
| GO Classification
|
| Biological Process |
| protein dephosphorylation |
| Cellular Component |
| cytosol |
| nucleus |
| Function |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| magnesium ion binding |
| phosphohistidine phosphatase activity |
| inorganic diphosphatase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Oxidative phosphorylation | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10q26.13 |
| SNPs
| LHPP |
| Gene Sequence
|
>813 bp
ATGGCACCGTGGGGCAAGCGGCTGGCTGGCGTGCGCGGGGTGCTGCTTGACATCTCGGGC
GTGCTGTACGACAGCGGCGCGGGCGGCGGCACGGCCATCGCCGGCTCGGTGGAGGCGGTG
GCCAGACTGAAGCGTTCCCGGCTGAAGGTGAGGTTCTGCACCAACGAGTCGCAGAAGTCC
CGGGCAGAGCTGGTGGGGCAGCTTCAGAGGCTGGGATTTGACATCTCTGAGCAGGAGGTG
ACCGCCCCGGCACCAGCTGCCTGCCAGATCCTGAAGGAGCGAGGCCTGCGACCATACCTG
CTCATCCATGACGGAGTCCGCTCAGAATTTGATCAGATCGACACATCCAACCCAAACTGT
GTGGTAATTGCAGACGCAGGAGAAAGCTTTTCTTATCAAAACATGAATAACGCCTTCCAG
GTGCTCATGGAGCTGGAAAAACCTGTGCTCATATCACTGGGAAAAGGGCGTTACTACAAG
GAGACCTCTGGCCTGATGCTGGACGTTGGTCCCTACATGAAGGCGCTTGAGTATGCCTGT
GGCATCAAAGCCGAGGTGGTGGGGAAGCCTTCTCCTGAGTTTTTCAAGTCTGCCCTGCAA
GCGATAGGAGTGGAAGCCCACCAGGCCGTCATGATTGGGGACGATATCGTGGGCGACGTC
GGCGGTGCCCAGCGGTGTGGAATGAGAGCGCTGCAGGTGCGCACCGGGAAGTTCAGGCCC
AGTGACGAGCACCATCCGGAAGTGAAGGCTGATGGGTACGTGGACAACCTCGCAGAGGCA
GTGGACCTGCTGCTGCAGCACGCCGACAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 270 |
| Molecular Weight
| 22695.865 |
| Theoretical pI
| 7.208 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
MAPWGKRLAGVRGVLLDISGVLYDSGAGGGTAIAGSVEAVARLKRSRLKVRFCTNESQKS
RAELVGQLQRLGFDISEQEVTAPAPAACQILKEQGLRPYLLIHDGVRSEFDQIDTSNPNC
VVIADAGESFSYQNMNNAFQVLMELEKPVLISLGKGRYYKETSGLMLDVGPYMKALEYAC
GIKAEVVGKPSPEFFKSALQAIGVEAHQAVMIGDDIVGDVGGAQRCGMRALQVRTGKFRP
SDEHHPEVKADGYVDNLAEAVDLLLQHADK
|
| External Links |
|---|
| GenBank ID Protein
| 10716807 |
| UniProtKB/Swiss-Prot ID
| Q9H008 |
| UniProtKB/Swiss-Prot Entry Name
| LHPP_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB049629 |
| GeneCard ID
| LHPP |
| GenAtlas ID
| LHPP |
| HGNC ID
| HGNC:30042 |
| References |
|---|
| General References
| Not Available |