| Identification |
|---|
| HMDB Protein ID
| CDBP04702 |
| Secondary Accession Numbers
| Not Available |
| Name
| GDP-fucose protein O-fucosyltransferase 2 |
| Description
| Not Available |
| Synonyms
|
- O-FucT-2
- Peptide-O-fucosyltransferase 2
|
| Gene Name
| POFUT2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in peptide-O-fucosyltransferase activity |
| Specific Function
| Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in thrombospondin type 1 repeats |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Endoplasmic reticulum
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 21q22.3 |
| SNPs
| POFUT2 |
| Gene Sequence
|
>1290 bp
ATGGCGACACTCAGCTTCGTCTTCCTGCTGCTGGGGGCAGTGTCCTGGCCTCCGGCTTCT
GCCTCCGGCCAGGAGTTCTGGCCCGGACAATCGGCGGCCGATATTCTGTCGGGGGCGGCT
TCCCGCAGACGGTATCTTCTGTATGACGTCAACCCCCCGGAAGGCTTCAACCTGCGCAGG
GATGTCTATATCCGAATCGCCTCTCTCCTGAAGACTCTGCTGAAGACGGAGGAGTGGGTG
CTTGTCCTGCCTCCATGGGGCCGCCTCTATCACTGGCAGAGTCCTGACATCCACCAGGTC
CGGATTCCCTGGTCTGAGTTTTTTGATCTTCCAAGTCTCAATAAAAACATCCCCGTCATC
GAGTATGAGCAGTTCATCGCAGAATCTGGTGGGCCCTTTATTGACCAGGTTTACGTCCTG
CAAAGTTACGCAGAGGGGTGGAAAGAAGGGACCTGGGAAGAGAAGGTGGACGAGCGGCCG
TGTATTGATCAGCTCCTGTACTCCCAGGACAAGCACGAGTACTACAGAGGATGGTTTTGG
GGTTATGAGGAGACCAGGGGTCTAAACGTCTCCTGTCTGTCCGTCCAGGGCTCAGCCTCC
ATCGTGGCGCCCCTGCTGCTGAGAAACACATCAGCCCGGTCCGTGATGTTAGACAGAGCC
GAGAACCTACTTCACGACCACTATGGAGGGAAAGAATACTGGGATACCCGTCGCAGCATG
GTGTTTGCCAGGCACCTGCGGGAGGTGGGAGACGAGTTCAGGAGCAGACATCTCAACTCC
ACGGACGACGCAGACAGGATCCCCTTCCAGGAGGACTGGATGAAGATGAAGGTCAAGCTG
GGCTCCGCGCTAGGGGGCCCCTACCTGGGAGTCCACCTGAGAAGAAAAGATTTCATCTGG
GGTCACAGACAGGATGTACCCAGTCTGGAAGGGGCCGTGAGGAAGATCCGCAGCCTCATG
AAGACCCACCGGCTGGACAAGGTGTTTGTGGCCACAGATGCCGTCAGAAAGGAATATGAA
GAGCTAAAAAAGCTGTTACCCGAGATGGTGAGGTTTGAACCCACGTGGGAGGAGCTGGAG
CTCTACAAGGACGGAGGCGTTGCGATTATTGACCAGTGGATCTGCGCACACGCCAGGTTT
TTTATTGGCACCTCAGTCTCAACATTTTCTTTTCGGATTCATGAGGAAAGAGAAATCCTG
GGGTTGGACCCCAAGACGACGTACAACAGGTTCTGCGGAGACCAAGAGAAGGCGTGTGAG
CAACCCACCCACTGGAAGATCACCTACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 429 |
| Molecular Weight
| 49975.4 |
| Theoretical pI
| 6.58 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>GDP-fucose protein O-fucosyltransferase 2
MATLSFVFLLLGAVSWPPASASGQEFWPGQSAADILSGAASRRRYLLYDVNPPEGFNLRR
DVYIRIASLLKTLLKTEEWVLVLPPWGRLYHWQSPDIHQVRIPWSEFFDLPSLNKNIPVI
EYEQFIAESGGPFIDQVYVLQSYAEGWKEGTWEEKVDERPCIDQLLYSQDKHEYYRGWFW
GYEETRGLNVSCLSVQGSASIVAPLLLRNTSARSVMLDRAENLLHDHYGGKEYWDTRRSM
VFARHLREVGDEFRSRHLNSTDDADRIPFQEDWMKMKVKLGSALGGPYLGVHLRRKDFIW
GHRQDVPSLEGAVRKIRSLMKTHRLDKVFVATDAVRKEYEELKKLLPEMVRFEPTWEELE
LYKDGGVAIIDQWICAHARFFIGTSVSTFSFRIHEEREILGLDPKTTYNRFCGDQEKACE
QPTHWKITY
|
| External Links |
|---|
| GenBank ID Protein
| 34147487 |
| UniProtKB/Swiss-Prot ID
| Q9Y2G5 |
| UniProtKB/Swiss-Prot Entry Name
| OFUT2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_133635.4 |
| GeneCard ID
| POFUT2 |
| GenAtlas ID
| POFUT2 |
| HGNC ID
| HGNC:14683 |
| References |
|---|
| General References
| Not Available |