| Identification |
|---|
| HMDB Protein ID
| CDBP04698 |
| Secondary Accession Numbers
| Not Available |
| Name
| DNA dC->dU-editing enzyme APOBEC-3H |
| Description
| Not Available |
| Synonyms
|
- APOBEC-related protein 10
- ARP-10
- Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H
|
| Gene Name
| APOBEC3H |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| DNA cytidine deaminase which may provide cellular innate resistance to a specific panel of genetic invaders including endogenous retroelements and a subset of viruses.
|
| GO Classification
|
| Biological Process |
| negative regulation of transposition |
| negative regulation of retroviral genome replication |
| defense response to virus |
| DNA cytosine deamination |
| Cellular Component |
| cytoplasm |
| nucleus |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| transition metal ion binding |
| zinc ion binding |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines |
| Molecular Function |
| zinc ion binding |
| metal ion binding |
| cytidine deaminase activity |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| 22q13.1 |
| SNPs
| APOBEC3H |
| Gene Sequence
|
>603 bp
ATGGCTCTGTTAACAGCCGAAACATTCCGCTTACAGTTTAACAACAAGCGCCGCCTCAGA
AGGCCTTACTACCCGAGGAAGGCCCTCTTGTGTTACCAGCTGACGCCGCAGAATGGCTCC
ACGCCCACGAGAGGCTACTTTGAAAACAAGAAAAAGTGCCATGCAGAAATTTGCTTTATT
AACGAGATCAAGTCCATGGGACTGGACGAAACGCAGTGCTACCAAGTCACCTGTTACCTC
ACGTGGAGCCCCTGCTCCTCCTGTGCCTGGGAGCTGGTTGACTTCATCAAGGCTCACGAC
CATCTGAACCTGGGCATCTTCGCCTCCCGCCTGTACTACCACTGGTGCAAGCCCCAGCAG
AAGGGGCTGCGGCTTCTGTGTGGATCCCAGGTCCCGGTGGAGGTCATGGGCTTCCCAAAG
TTTGCTGACTGCTGGGAAAACTTTGTGGACCACGAGAAACCGCTTTCCTTCAACCCCTAT
AAGATGTTAGAGGAGCTAGATAAAAACAGTCGAGCCATAAAGCGACGGCTTGAGAGGATA
AAGATTCCAGGGGTACGTGCGCAGGGTCGTTACATGGATATATTGTGTGATGCTGAGGTC
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 200 |
| Molecular Weight
| 21529.795 |
| Theoretical pI
| 8.923 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>DNA dC->dU-editing enzyme APOBEC-3H
MALLTAETFRLQFNNKRRLRRPYYPRKALLCYQLTPQNGSTPTRGYFENKKKCHAEICFI
NEIKSMGLDETQCYQVTCYLTWSPCSSCAWELVDFIKAHDHLNLGIFASRLYYHWCKPQQ
KGLRLLCGSQVPVEVMGFPKFADCWENFVDHEKPLSFNPYKMLEELDKNSRAIKRRLERI
KIPGVRAQGRYMDILCDAEV
|
| External Links |
|---|
| GenBank ID Protein
| 168984003 |
| UniProtKB/Swiss-Prot ID
| Q6NTF7 |
| UniProtKB/Swiss-Prot Entry Name
| ABC3H_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AL031846 |
| GeneCard ID
| APOBEC3H |
| GenAtlas ID
| APOBEC3H |
| HGNC ID
| HGNC:24100 |
| References |
|---|
| General References
| Not Available |