| Identification |
|---|
| HMDB Protein ID
| CDBP04687 |
| Secondary Accession Numbers
| Not Available |
| Name
| Leucine carboxyl methyltransferase 1 |
| Description
| Not Available |
| Synonyms
|
- Protein-leucine O-methyltransferase
- [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1
|
| Gene Name
| LCMT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in methyltransferase activity |
| Specific Function
| Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
|
| GO Classification
|
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring one-carbon groups |
| methyltransferase activity |
| Molecular Function |
| S-adenosylmethionine-dependent methyltransferase activity |
| protein C-terminal carboxyl O-methyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| 16p12.1 |
| SNPs
| LCMT1 |
| Gene Sequence
|
>1005 bp
ATGGCCACTAGGCAGAGGGAATCCTCTATCACCTCCTGCTGTTCCACCTCGAGCTGCGAC
GCAGACGACGAGGGCGTGCGCGGCACCTGCGAAGATGCTTCCCTGTGCAAGAGGTTTGCA
GTAAGCATTGGCTACTGGCATGACCCTTACATACAGCACTTTGTGAGACTGTCTAAAGAG
AGGAAAGCCCCTGAAATCAACAGAGGATATTTTGCTCGAGTCCATGGTGTCAGTCAGCTT
ATAAAGGCATTTCTACGGAAGACAGAATGTCATTGTCAAATTGTCAACCTTGGGGCAGGC
ATGGATACCACCTTCTGGAGATTAAAGGATGAAGATCTTCTCCCAAGTAAATATTTTGAG
GTTGACTTTCCAATGATTGTCACGAGAAAGCTGCACAGTATCAAATGCAAGCCTCCCCTA
TCCAGCCCCATTCTAGAACTGCATTCAGAGGACACACTTCAGATGGATGGACACATACTG
GATTCAAAGAGATATGCCGTTATTGGAGCAGATCTCCGAGACCTGTCTGAACTGGAAGAG
AAGCTAAAGAAATGTAACATGAATACACAATTGCCAACACTCCTGATAGCTGAATGTGTG
CTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTCCTGAAGTGGGCAGCCAACAGTTTT
GAGAGAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCAGATC
ATGATTGAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCA
TTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGGGTGGGAAACAGCATCGGCCGTCGAC
ATGATGGAGTTGTACAACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACTTGAA
TTCCTGGATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCA
ACCAAAGGAGGAAATGAGCTTGGGCTGAAGGAGATAACTTATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 334 |
| Molecular Weight
| 32171.66 |
| Theoretical pI
| 6.314 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Leucine carboxyl methyltransferase 1
MATRQRESSITSCCSTSSCDADDEGVRGTCEDASLCKRFAVSIGYWHDPYIQHFVRLSKE
RKAPEINRGYFARVHGVSQLIKAFLRKTECHCQIVNLGAGMDTTFWRLKDEDLLPSKYFE
VDFPMIVTRKLHSIKCKPPLSSPILELHSEDTLQMDGHILDSKRYAVIGADLRDLSELEE
KLKKCNMNTQLPTLLIAECVLVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQI
MIENLRRRQCDLAGVETCKSLESQKERLLSNGWETASAVDMMELYNRLPRAEVSRIESLE
FLDEMELLEQLMRHYCLCWATKGGNELGLKEITY
|
| External Links |
|---|
| GenBank ID Protein
| 74048434 |
| UniProtKB/Swiss-Prot ID
| Q9UIC8 |
| UniProtKB/Swiss-Prot Entry Name
| LCMT1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_016309.2 |
| GeneCard ID
| LCMT1 |
| GenAtlas ID
| LCMT1 |
| HGNC ID
| HGNC:17557 |
| References |
|---|
| General References
| Not Available |