| Identification |
|---|
| HMDB Protein ID
| CDBP04665 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ninein |
| Description
| Not Available |
| Synonyms
|
- GSK3B-interacting protein
- Glycogen synthase kinase 3 beta-interacting protein
- hNinein
|
| Gene Name
| NIN |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cytoplasm
- cytoskeleton
- centrosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 14q22.1 |
| SNPs
| NIN |
| Gene Sequence
|
>6273 bp
ATGGATGAGGTGGAGCAGGACCAGCATGAGGCCCGACTCAAGGAGCTGTTTGACAGTTTT
GACACGACGGGCACAGGGTCCCTGGGGCAGGAGGAACTCACCGACCTTTGCCACATGTTG
AGCTTGGAGGAGGTGGCCCCAGTGCTGCAGCAGACATTACTTCAGGACAACCTCTTGGGC
AGGGTACATTTTGACCAATTTAAAGAAGCATTAATACTCATCTTGTCCAGAACTCTGTCA
AATGAAGAACACTTTCAAGAACCAGACTGCTCACTAGAAGCTCAGCCCAAATATGTTAGA
GGTGGGAAGCGTTACGGACGAAGGTCCTTGCCCGAGTTCCAAGAGTCCGTGGAGGAGTTT
CCTGAAGTGACGGTGATTGAGCCACTGGATGAAGAAGCGCGGCCTTCACACATCCCAGCC
GGTGACTGCAGTGAGCACTGGAAGACGCAACGCAGTGAGGAGTATGAAGCGGAAGGCCAG
TTAAGGTTTTGGAACCCAGATGACTTGAATGCTTCACAGAGTGGATCTTCCCCTCCCCAA
GACTGGATAGAAGAGAAACTGCAAGAAGTTTGTGAAGATTTGGGGATCACCCGTGATGGT
CACCTGAACCGGAAGAAGCTGGTCTCCATCTGTGAGCAGTATGGTTTACAGAATGTGGAT
GGAGAGATGCTCGAGGAAGTATTCCATAATCTTGATCCTGACGGTACAATGAGTGTAGAA
GATTTTTTCTATGGTTTGTTTAAAAATGGAAAATCTCTTACACCATCAGCATCTACTCCA
TATAGACAACTAAAAAGGCACCTTTCCATGCAGTCTTTCGATGAGAGTGGACGACGTACC
ACAACCTCATCAGCAATGACAAGTACCATTGGCTTTCGGGTCTTCTCCTGCCTGGATGAT
GGGATGGGCCATGCATCTGTGGAGAGAATACTGGACACCTGGCAGGAAGAGGGCATTGAG
AACAGCCAGGAGATCCTGAAGGCCTTGGATTTCAGCCTCGATGGAAACATCAATTTGACA
GAATTAACACTGGCCCTTGAAAATGAACTTTTGGTTACCAAGAACAGCATTCACCAGGCG
GCTCTGGCCAGCTTTAAGGCTGAAATCCGGCATTTGTTGGAACGAGTTGATCAGGTGGTC
AGAGAAAAAGAGAAGCTACGGTCAGATCTGGACAAGGCCGAGAAGCTCAAGTCTTTAATG
GCCTCGGAGGTGGATGATCACCATGCGGCCATAGAGCGGCGGAATGAGTACAACCTCAGG
AAACTGGATGAAGAGTACAAGGAGCGAATAGCAGCCTTAAAAAATGAACTCCGAAAAGAG
AGAGAGCAGATCCTGCAGCAGGCAGGCAAGCAGCGTTTAGAACTTGAACAGGAAATTGAA
AAGGCAAAAACAGAAGAGAACTATATCCGGGACCGCCTTGCCCTCTCTTTAAAGGAAAAC
AGTCGTCTGGAAAATGAGCTTCTAGAAAATGCAGAGAAGTTGGCAGAATATGAGAATCTG
ACAAACAAACTTCAGAGAAATTTGGAAAATGTGTTAGCAGAAAAGTTTGGTGACCTCGAT
CCTAGCAGTGCTGAGTTCTTCCTGCAAGAAGAGAGACTGACACAGATGAGAAATGAATAT
GAGCGGCAGTGCAGGGTACTACAAGACCAAGTAGATGAACTCCAGTCTGAGCTGGAAGAA
TATCGTGCACAAGGCAGAGTGCTCAGGCTTCCGTTGAAGAACTCACCGTCAGAAGAAGTT
GAGGCTAACAGCGGTGGCATTGAGCCCGAACACGGGCTCGGTTCTGAAGAATGCAATCCA
TTGAATATGAGCATTGAGGCAGAGCTGGTCATTGAACAGATGAAAGAACAACATCACAGG
GACATATGTTGCCTCAGACTGGAGCTCGAAGATAAAGTGCGCCATTATGAAAAGCAGCTG
GACGAAACCGTGGTCAGCTGCAAGAAGGCACAGGAGAACATGAAGCAAAGGCATGAGAAC
GAAACGCACACCTTAGAAAAACAAATAAGTGACCTTAAAAATGAAATTGCTGAACTTCAG
GGGCAAGCAGCAGTGCTCAAGGAGGCACATCATGAGGCCACTTGCAGGCATGAGGAGGAG
AAAAAACAACTGCAAGTGAAGCTTGAGGAGGAAAAGACTCACCTGCAGGAGAAGCTGAGG
CTGCAACATGAGATGGAGCTCAAGGCTAGACTGACACAGGCTCAAGCAAGCTTTGAGCGG
GAGAGGGAAGGCCTTCAGAGTAGCGCCTGGACAGAAGAGAAGGTGAGAGGCTTGACTCAG
GAACTAGAGCAGTTTCACCAGGAGCAGCTGACAAGCCTGGTGGAGAAACACACTCTTGAG
AAAGAGGAGTTAAGAAAAGAGCTCTTGGAAAAGCACCAAAGGGAGCTTCAGGAGGGAAGG
GAAAAAATGGAAACAGAGTGTAATAGAAGAACCTCTCAAATAGAAGCCCAGTTTCAGTCT
GATTGTCAGAAAGTCACTGAGAGGTGTGAAAGCGCTCTGCAAAGCCTGGAGGGGCGCTAC
CGCCAAGAGCTGAAGGACCTCCAGGAACAGCAGCGTGAGGAGAAATCCCAGTGGGAATTT
GAGAAGGACGAGCTCACCCAGGAGTGTGCGGAAGCCCAGGAGCTGCTGAAAGAGACTCTT
AAGAGAGAGAAAACAACTTCTCTGGTCCTGACCCAGGAGAGAGAGATGCTGGAGAAAACA
TACAAAGAACATTTGAACAGCATGGTCGTCGAGAGACAGCAGCTACTCCAAGACCTGGAA
GACCTAAGAAATGTATCTGAAACCCAGCAAAGCCTGCTGTCTGACCAGATACTTGAGCTG
AAGAGCAGTCACAAAAGGGAACTGAGGGAGCGTGAGGAGGTCCTGTGCCAGGCAGGGGCT
TCGGAGCAGCTGGCCAGCCAGCGGCTGGAAAGACTAGAAATGGAACATGACCAGGAAAGG
CAGGAAATGATGTCCAAGCTTCTAGCCATGGAGAACATTCACAAAGCGACCTGTGAGACA
GCAGATCGAGAAAGAGCCGAGATGAGCACAGAAATCTCCAGACTTCAGAGTAAAATAAAG
GAAATGCAGCAGGCAACATCTCCTCTCTCAATGCTTCAGAGTGGTTGCCAGGTGATAGGA
GAGGAGGAGGTGGAAGGAGATGGAGCCCTGTCCCTGCTTCAGCAAGGGGAGCAGCTGTTG
GAAGAAAATGGGGACGTCCTCTTAAGCCTGCAGAGAGCTCATGAACAGGCAGTGAAGGAA
AATGTGAAAATGGCTACTGAAATTTCTAGATTGCAACAGAGGCTACAAAAGTTAGAGCCA
GGGTTAGTAATGTCTTCTTGTTTGGATGAGCCAGCTACTGAGTTTTTTGGAAATACTGCG
GAACAAACAGAGCCGTTTTTACAGCAAAACCGAACGAAGCAAGTAGAAGGTGTGACCAGG
CGGCATGTCCTAAGTGACCTGGAAGATGATGAGGTCCGGGACCTGGGAAGTACAGGGACG
AGCTCTGTTCAGAGACAGGAAGTCAAAATAGAGGAGTCTGAAGCTTCAGTAGAGGGTTTT
TCTGAGCTTGAAAACAGTGAAGAGACCAGGACTGAATCCTGGGAGCTGAAGAATCAGATT
AGTCAGCTTCAGGAACAGCTAATGATGTTATGTGCGGACTGTGATCGAGCTTCTGAAAAG
AAACAGGACCTACTTTTTGATGTTTCTGTGCTAAAAAAGAAACTGAAGATGCTTGAGAGA
ATCCCTGAGGCTTCTCCCAAATATAAGCTGTTGTATGAAGATGTGAGCCGAGAAAATGAC
TGCCTTCAGGAAGAGCTGAGAATGATGGAGACACGCTACGATGAGGCACTAGAAAATAAC
AAAGAACTCACTGCAGAGGTTTTCAGGTTGCAGGATGAGCTGAAGAAAATGGAGGAAGTC
ACTGAAACATTCCTCAGCCTGGAAAAGAGTTACGATGAGGTCAAAATAGAAAATGAGGAG
CTGAATGTTCTGGTTTTGAGACTTCAAGGCAAGATTGAGAAGCTTCAGGAAAGCGTGGTC
CAGCGGTGTGACTGCTGCTTATGGGAAGCCAGTTTAGAGAACCTGGAAATCGAACCTGAT
GGAAATATACTCCAGCTCAATCAGACACTGGAAGAGTGTGTGCCCAGGGTTAGGAGTGTA
CATCATGTCATAGAGGAATGTAAGCAAGAAAACCAGTACCTTGAGGGGAACACACAGCTC
TTGGAAAAAGTAAAAGCACATGAAATTGCCTGGTTACATGGAACAATTCAGACACATCAA
GAAAGGCCAAGAGTACAGAATCAAGTTATACTGGAGGAAAACACTACTCTCCTAGGCTTT
CAAGACAAACATTTTCAGCATCAGGCCACCATAGCAGAGTTAGAACTGGAGAAAACAAAG
TTACAGGAGCTGACTAGGAAGTTGAAGGAGAGAGTCACTATTTTAGTTAAGCAAAAAGAT
GTACTTTCTCACGGAGAAAAGGAGGAAGAGCTGAAGGCAATGATGCATGACTTGCAGATC
ACGTGCAGTGAGATGCAGCAAAAAGTTGAACTTCTGAGATATGAATCTGAAAAGCTTCAA
CAGGAAAATTCTATTTTGAGAAATGAAATTACTACTTTAAATGAAGAAGATAGCATTTCT
AACCTGAAATTAGGGACATTAAATGGATCTCAGGAAGAAATGTGGCAAAAAACGGAAACT
GTAAAACAAGAAAATGCTGCAGTTCAGAAGATGGTTGAAAATTTAAAGAAACAGATTTCA
GAATTAAAAATCAAAAACCAACAATTGGATTTGGAAAATACAGAACTTAGCCAAAAGAAC
TCTCAAAACCAGGAAAAACTGCAAGAACTTAATCAACGTCTAACAGAAATGCTATGCCAG
AAGGAAAAAGAGCCAGGAAACAGTGCATTGGAGGAACGGGAACAAGAGAAGTTTAATCTG
AAAGAAGAACTGGAACGTTGTAAAGTGCAGTCCTCCACTTTAGTGTCTTCTCTGGAGGCG
GAGCTCTCTGAAGTTAAAATACAGACCCATATTGTGCAACAGGAAAACCACCTTCTCAAA
GATGAACTGGAGAAAATGAAACAGCTGCACAGATGTCCCGATCTCTCTGACTTCCAGCAA
AAAATCTCTAGTGTTCTAAGCTACAACGAAAAACTGCTGAAAGAAAAGGAAGCTCTGAGT
GAGGAATTAAATAGCTGTGTCGATAAGTTGGCAAAATCAAGTCTTTTAGAGCATAGAATT
GCGACGATGAAGCAGGAACAGAAATCCTGGGAACATCAGAGTGCGAGCTTAAAGTCACAG
CTGGTGGCTTCTCAGGAAAAGGTTCAGAATTTAGAAGACACCGTGCAGAATGTAAACCTG
CAAATGTCCCGGATGAAATCTGACCTACGAGTGACTCAGCAGGAAAAGGAGGCTTTAAAA
CAAGAAGTGATGTCTTTACATAAGCAACTTCAGAATGCTGGTGGCAAGAGCTGGGCCCCA
GAGATAGCTACTCATCCATCAGGGCTCCATAACCAGCAGAAAAGGCTGTCCTGGGACAAG
TTGGATCATCTGATGAATGAGGAACAGCAGCTGCTTTGGCAAGAGAATGAGAGGCTCCAG
ACCATGGTACAGAACACCAAAGCCGAACTCACGCACTCCCGGGAGAAGGTCCGTCAGTTG
GAATCCAATCTTCTTCCCAAGCACCAAAAACATCTAAACCCATCAGGTACCATGAATCCC
ACAGAGCAAGAAAAATTGAGCTTAAAGAGAGAGTGTGATCAGTTTCAGAAAGAACAATCT
CCTGCTAACAGGAAGGTCAGTCAGATGAATTCCCTTGAACAAGAATTAGAAACAATTCAT
TTGGAAAATGAAGGCCTGAAAAAGAAACAAGTAAAACTGGATGAGCAGCTCATGGAGATG
CAGCACCTGAGGTCCACTGCGACGCCTAGCCCGTCCCCTCATGCTTGGGATTTGCAGCTG
CTCCAGCAGCAAGCCTGTCCGATGGTGCCCAGGGAGCAGTTTCTGCAGCTTCAACGCCAG
CTGCTGCAGGCAGAAAGGATAAACCAGCACCTGCAGGAGGAACTTGAAAACAGGACCTCC
GAAACCAACACACCACAGGGAAACCAGGAACAACTGGTAACTGTCATGGAGGAACGAATG
ATAGAAGTTGAACAGAAACTGAAACTAGTGAAAAGGCTTCTTCAAGAGAAAGTGAATCAG
CTCAAAGAACAAGTGAGCCTACCCGGTCATCTCTGTTCACCCACCTCACATTCCAGCTTT
AACTCCAGTTTTACATCCCTTTATTGCCATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 2090 |
| Molecular Weight
| 243288.5 |
| Theoretical pI
| 4.7 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ninein
MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF
PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE
DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD
GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA
ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR
KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN
SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY
ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP
LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN
ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR
LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE
KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY
RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT
YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA
SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK
EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE
NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR
RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI
SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND
CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE
LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV
HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF
QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI
TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET
VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ
KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK
DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI
ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK
QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ
TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS
PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL
LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERM
IEVEQKLKLVKRLLQEKVNQLKEQVSLPGHLCSPTSHSSFNSSFTSLYCH
|
| External Links |
|---|
| GenBank ID Protein
| 33946321 |
| UniProtKB/Swiss-Prot ID
| Q8N4C6 |
| UniProtKB/Swiss-Prot Entry Name
| NIN_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_182946.1 |
| GeneCard ID
| NIN |
| GenAtlas ID
| NIN |
| HGNC ID
| HGNC:14906 |
| References |
|---|
| General References
| Not Available |