| Identification |
|---|
| HMDB Protein ID
| CDBP04655 |
| Secondary Accession Numbers
| Not Available |
| Name
| Poly(ADP-ribose) glycohydrolase |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| PARG |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in poly(ADP-ribose) glycohydrolase activity |
| Specific Function
| Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells |
| GO Classification
|
| Function |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on glycosyl bonds |
| hydrolase activity, hydrolyzing o-glycosyl compounds |
| poly(adp-ribose) glycohydrolase activity |
| Process |
| metabolic process |
| primary metabolic process |
| carbohydrate metabolic process |
|
| Cellular Location
|
- Isoform 3:Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q11.23 |
| SNPs
| PARG |
| Gene Sequence
|
>2931 bp
ATGAATGCGGGCCCCGGCTGTGAACCCTGCACCAAAGCGACCCGCTGGGGCGCCGCTACA
ACTTCGCCGGCTGCTTCGGACGCCCGGAGCTTTCCGAGCAGGCAGAGGCGCGTCCTCGAC
CCCAAGGACGCTCACGTGCAGTTCAGGGTCCCACCGTCCTCGCCAGCCTGCGTCCCAGGG
CAGGCGGGACAGCACAGAGGCAGCGCCACCTCGCTTGTTTTCAAACAAAAGACTATTACC
AGTTGGATGGACACTAAAGGAATCAAGACAGCGGAATCAGAAAGTTTGGATAGTAAAGAA
AACAACAATACAAGAATAGAATCCATGATGAGTTCTGTACAAAAAGATAACTTTTACCAA
CATAATGTAGAAAAATTAGTAAATGTTTCTCAGCTAAGTCTTGATAAGTCACTCACTGAA
AAAAGTACACAGTATTTGAACCAGCATCAGACTGCAGCAATGTGTAAGTGGCAAAATGAA
GGGAAACACACGGAGCAGCTTTTGGAAAGTGAACCTCAAACAGTAACCCTGGTACCAGAG
CAGTTTAGTAATGCTAACATTGATCGGTCACCTCAAAATGATGATCACAGTGACACAGAT
AGTGAAGAGAATAGAGACAATCAACAGTTTCTCACAACTGTAAAGCTTGCAAATGCAAAG
CAGACTACGGAAGATGAACACGCCAGAGAAGCCAAAAGCCACCAGAAGTGCAGCAAGTCT
TGCCATCCTGGGGAAGACTGTGCAAGTTGTCAGCAAGATGAGATAGACGTGGTGCCAAAG
AGTCCATTGTCAGATGTTGGCTCTGAGGATGTTGGTACTGGGTCAAAAAATGACAACAAA
TTGATTAGACAAGAAAGTTGCCTAGGAAATTCTCCTCCATTTGAGAAGGAAAGTGAACCC
GAATCACCGATGGATGTGGATAATTCTAAAAATAGTTGTCAAGACTCAGAAGCAGATGAG
GAGACAAGTCCAGGTTTTGATGAACAAGAAGATGGTAGTTCCTCCCAAACAGCAAATAAA
CCTTCAAGGTTCCAAGCAAGAGACGCTGACATTGAATTTAGGAAACGGTACTCTACTAAG
GGCGGTGAAGTTAGATTACATTTCCAATTTGAAGGAGGAGAGAGTCGCACTGGAATGAAT
GATTTAAATGCTAAACTACCTGGAAATATTTCTAGCCTGAATGTAGAATGCAGAAATTCT
AAGCAACATGGAAAAAAGGATTCTAAAATCACAGATCATTTGATGAGACTGCCCAAAGCA
GAGGACAGAAGAAAAGAACAGTGGGAAACCAAACATCAAAGAACAGAAAGGAAGATCCCT
AAATACGTTCCACCTCACCTTTCTCCAGATAAGAAGTGGCTTGGAACTCCCATTGAGGAG
ATGAGAAGAATGCCTCGGTGTGGGATCCGGCTGCCTCTCTTGAGACCATCTGCCAATCAC
ACAGTAACTATTCGGGTAGATCTTTTGCGAGCAGGAGAAGTTCCTAAACCTTTTCCAACA
CATTATAAAGATTTGTGGGATAACAAGCATGTTAAAATGCCTTGTTCAGAACAAAATTTG
TACCCAGTGGAAGATGAGAATGGTGAGCGAACTGCGGGGAGCCGGTGGGAGCTCATTCAG
ACTGCACTTCTCAACAAATTTACACGACCCCAAAACTTGAAGGATGCTATTCTGAAATAC
AATGTGGCATATTCTAAGAAATGGGACTTTACAGCTTTGATCGATTTCTGGGATAAGGTA
CTTGAAGAAGCAGAAGCTCAACATTTATATCAGTCCATCTTGCCTGATATGGTGAAAATT
GCACTCTGTCTGCCAAATATTTGCACCCAGCCAATACCACTCCTGAAACAGAAGATGAAT
CATTCCATCACAATGTCGCAGGAACAGATTGCCAGTCTTTTAGCTAATGCTTTCTTCTGC
ACATTTCCACGACGAAATGCTAAGATGAAATCGGAGTATTCTAGTTACCCAGACATTAAC
TTCAATCGATTGTTTGAGGGACGTTCATCAAGGAAACCGGAGAAACTTAAAACGCTCTTC
TGCTACTTTAGAAGAGTCACAGAGAAAAAACCTACTGGGTTGGTGACATTTACAAGACAG
AGTCTTGAAGATTTTCCAGAATGGGAAAGATGTGAAAAACCCTTGACACGATTGCATGTC
ACTTACGAAGGTACCATAGAAGAAAATGGCCAAGGCATGCTACAGGTGGATTTTGCAAAT
CGTTTTGTTGGAGGTGGTGTAACCAGTGCAGGACTTGTGCAAGAAGAAATCCGCTTTTTA
ATCAATCCTGAGTTGATTATTTCACGGCTCTTCACTGAGGTGCTGGATCACAATGAATGT
CTAATTATCACAGGTACTGAGCAGTACAGTGAATACACAGGCTATGCTGAGACATATCGT
TGGTCCCGGAGCCACGAAGATGGGAGTGAAAGGGACGACTGCGAGCGGCGCTGCACTGAG
ATCGTTGCCATCGATGCTCTTCACTTCAGACGCTACCTCGATCAGTTTGTGCCTGAGAAA
ATGAGACGCGAGCTGAACAAGGCTTACTGTGGATTTCTCCGTCCTGGAGTTTCTTCAGAG
AATCTTTCTGCAGTGGCCACAGGAAACTGGGGCTGTGGTGCCTTTGGGGGTGATGCCAGG
TTAAAAGCCTTAATACAGATATTGGCAGCTGCTGCAGCTGAGCGAGATGTGGTTTATTTC
ACCTTTGGGGACTCAGAATTGATGAGAGACATTTACAGCATGCACATTTTCCTTACTGAA
AGGAAACTCACTGTTGGAGATGTGTATAAGCTGTTGCTACGATACTACAATGAAGAATGC
AGAAACTGTTCCACCCCTGGACCAGACATCAAGCTTTATCCATTCATATACCATGCTGTC
GAGTCCTGTGCAGAGACCGCTGACCATTCAGGGCAAAGGACAGGGACCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 976 |
| Molecular Weight
| 111109.5 |
| Theoretical pI
| 6.39 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Poly(ADP-ribose) glycohydrolase
MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPG
RAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQ
HNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPE
QFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKS
CDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEP
ESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTK
GGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKA
EDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANH
TVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQ
TALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKI
ALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDIN
FNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHV
TYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNEC
LIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEK
MRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYF
TFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAV
ESCAETADHSGQRTGT
|
| External Links |
|---|
| GenBank ID Protein
| 2213922 |
| UniProtKB/Swiss-Prot ID
| Q86W56 |
| UniProtKB/Swiss-Prot Entry Name
| PARG_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF005043 |
| GeneCard ID
| PARG |
| GenAtlas ID
| PARG |
| HGNC ID
| HGNC:8605 |
| References |
|---|
| General References
| Not Available |