| Identification |
| HMDB Protein ID
| CDBP04630 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ubiquitin carboxyl-terminal hydrolase 26 |
| Description
| Not Available |
| Synonyms
|
- Deubiquitinating enzyme 26
- Ubiquitin thiolesterase 26
- Ubiquitin-specific-processing protease 26
|
| Gene Name
| USP26 |
| Protein Type
| Enzyme |
| Biological Properties |
| General Function
| Involved in ubiquitin thiolesterase activity |
| Specific Function
| Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquinates the androgen receptor and regulates the androgen receptor signaling pathway |
| GO Classification
|
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| ubiquitin thiolesterase activity |
| thiolester hydrolase activity |
| Process |
| ubiquitin-dependent protein catabolic process |
| metabolic process |
| catabolic process |
| macromolecule catabolic process |
| cellular macromolecule catabolic process |
| modification-dependent macromolecule catabolic process |
| modification-dependent protein catabolic process |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| USP26 |
| Gene Sequence
|
>2742 bp
ATGGCTGCCCTATTCCTACGTGGTTTTGTCCAAATAGGGAACTGCAAGACTGGGATATCT
AAGTCAAAAGAAGCATTCATTGAAGCAGTGGAAAGAAAGAAGAAAGATAGACTGGTGCTG
TATTTCAAAAGTGGAAAATATAGCACTTTTCGGCTAAGTGATAATATTCAAAATGTAGTC
CTTAAATCCTATAGAGGAAACCAAAATCACCTGCATTTAACTTTACAAAATAATAATGGC
TTGTTTATTGAAGGATTATCCTCCACAGATGCTGAACAATTGAAGATATTCTTGGACAGA
GTTCATCAAAACGAGGTTCAGCCACCTGTGAGACCTGGTAAGGGTGGGAGTGTCTTTTCT
AGCACAACACAGAAGGAAATCAACAAAACTTCATTCCACAAAGTTGATGAGAAATCAAGT
AGCAAATCTTTTGAGATAGCAAAAGGAAGTGGGACAGGTGTCCTTCAGAGGATGCCTTTG
CTTACATCAAAATTGACACTTACTTGCGGAGAGTTATCAGAAAATCAGCACAAGAAGAGG
AAAAGAATGCTCTCATCTAGCTCAGAGATGAATGAGGAATTCTTGAAAGAAAATAATTCT
GTAGAATACAAGAAATCCAAGGCAGATTGTTCGAGGTGTGTAAGCTATAATCGAGAGAAA
CAATTGAAGTTAAAAGAGTTAGAAGAGAATAAGAAATTGGAATGTGAATCTTCATGCATC
ATGAACGCCACTGGAAATCCTTACCTAGATGACATTGGTCTTCTCCAAGCTCTCACTGAG
AAAATGGTTTTGGTATTTCTGTTACAACAAGGGTATAGTGACGGTTACACAAAGTGGGAT
AAATTAAAACTATTTTTTGAATTATTTCCAGAGAAAATATGCCACGGCCTCCCCAATTTG
GGAAACACCTGTTATATGAATGCAGTGTTACAGTCTCTACTTTCAATCCCATCGTTTGCT
GATGATTTACTTAATCAGAGTTTCCCATGGGGTAAAATTCCCCTTAATGCTCTTACCATG
TGCTTGGCACGGCTACTTTTTTTTAAAGATACCTATAATATAGAAATCAAGGAGATGTTA
CTCTTGAATCTTAAAAAGGCCATTTCAGCAGCTGCAGAGATATTCCATGGCAATGCACAG
AACGATGCTCATGAGTTTTTAGCTCACTGTTTAGATCAACTGAAAGATAACATGGAAAAA
CTCAACACAATTTGGAAGCCTAAAAGTGAATTTGGGGAAGATAATTTTCCTAAACAGGTT
TTTGCTGATGATCCTGACACCAGTGGGTTTTCTTGCCCTGTCATTACTAATTTTGAGTTA
GAGTTGTTGCACTCCATTGCTTGTAAAGCTTGTGGTCAGGTTATTCTCAAGACAGAACTG
AATAATTACCTCTCCATCAACCTTCCCCAAAGAATAAAAGCACATCCTTCATCTATTCAG
TCTACTTTTGATCTTTTTTTTGGAGCAGAAGAGCTTGAGTATAAATGTGCAAAATGTGAG
CACAAGACTTCCGTTGGAGTGCACTCATTCAGTAGGCTACCTAGAATCCTTATTGTTCAC
CTCAAACGCTATAGCTTGAATGAGTTTTGTGCATTAAAGAAGAATGACCAGGAAGTCATC
ATTTCCAAATATTTAAAGGTGTCTTCTCATTGCAATGAAGGCACCAGACCACCTCTTCCC
TTGAGTGAGGATGGAGAAATTACAGATTTCCAATTATTAAAAGTTATTCGAAAGATGACT
TCTGGAAACATCAGTGTATCATGGCCTGCAACAAAGGAATCCAAAGATATCCTGGCTCCA
CACATTGGATCAGATAAGGAGTCTGAACAAAAAAAAGGCCAGACAGTCTTTAAAGGGGCA
AGCAGAAGACAGCAGCAAAAGTACCTTGGAAAAAATTCTAAACCAAATGAGCTAGAATCT
GTATACTCAGGAGATCGAGCATTCATTGAAAAAGAACCGTTAGCTCACTTAATGACGTAT
CTGGAAGATACCTCACTTTGTCAGTTCCACAAAGCTGGAGGTAAACCTGCCAGCAGCCCA
GGCACACCTCTCTCAAAAGTTGACTTTCAAACAGTGCCCGAAAATCCAAAACGAAAGAAA
TATGTGAAAACCAGTAAGTTTGTAGCTTTTGATAGGATTATCAATCCTACTAAAGATTTG
TATGAAGATAAAAATATCAGAATTCCAGAAAGATTCCAAAAAGTGTCTGAACAGACTCAG
CAGTGTGACGGTATGAGAATCTGTGAACAAGCCCCTCAGCAGGCACTGCCTCAAAGCTTT
CCAAAGCCAGGCACCCAGGGGCACACAAAGAACCTCCTAAGACCTACAAAATTAAATCTA
CAGAAGTCTAACAGGAATTCCCTACTTGCACTGGGTTCCAATAAGAATCCAAGAAACAAA
GACATTTTAGATAAGATAAAATCTAAAGCCAAGGAAACAAAAAGAAATGATGATAAGGGA
GATCATACCTACCGGCTCATTAGTGTTGTCAGCCATCTTGGGAAGACTCTAAAGTCAGGC
CATTATATCTGTGATGCCTATGACTTTGAGAAACAGATCTGGTTCACTTACGATGATATG
CGGGTGTTAGGTATCCAGGAGGCCCAGATGCAGGAGGATAGGCGTTGCACTGGGTACATC
TTCTTTTACATGCATAATGAGATCTTTGAAGAGATGTTGAAAAGAGAAGAGAATGCCCAG
CTTAATAGCAAGGAGGTAGAGGAGACCCTTCAGAAGGAATAA
|
| Protein Properties |
| Number of Residues
| 913 |
| Molecular Weight
| 104046.2 |
| Theoretical pI
| 8.96 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ubiquitin carboxyl-terminal hydrolase 26
MAALFLRGFVQIGNCKTGISKSKEAFIEAVERKKKDRLVLYFKSGKYSTFRLSDNIQNVV
LKSYRGNQNHLHLTLQNNNGLFIEGLSSTDAEQLKIFLDRVHQNEVQPPVRPGKGGSVFS
STTQKEINKTSFHKVDEKSSSKSFEIAKGSGTGVLQRMPLLTSKLTLTCGELSENQHKKR
KRMLSSSSEMNEEFLKENNSVEYKKSKADCSRCVSYNREKQLKLKELEENKKLECESSCI
MNATGNPYLDDIGLLQALTEKMVLVFLLQQGYSDGYTKWDKLKLFFELFPEKICHGLPNL
GNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTMCLARLLFFKDTYNIEIKEML
LLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSEFGEDNFPKQV
FADDPDTSGFSCPVITNFELELLHSIACKACGQVILKTELNNYLSINLPQRIKAHPSSIQ
STFDLFFGAEELEYKCAKCEHKTSVGVHSFSRLPRILIVHLKRYSLNEFCALKKNDQEVI
ISKYLKVSSHCNEGTRPPLPLSEDGEITDFQLLKVIRKMTSGNISVSWPATKESKDILAP
HIGSDKESEQKKGQTVFKGASRRQQQKYLGKNSKPNELESVYSGDRAFIEKEPLAHLMTY
LEDTSLCQFHKAGGKPASSPGTPLSKVDFQTVPENPKRKKYVKTSKFVAFDRIINPTKDL
YEDKNIRIPERFQKVSEQTQQCDGMRICEQAPQQALPQSFPKPGTQGHTKNLLRPTKLNL
QKSNRNSLLALGSNKNPRNKDILDKIKSKAKETKRNDDKGDHTYRLISVVSHLGKTLKSG
HYICDAYDFEKQIWFTYDDMRVLGIQEAQMQEDRRCTGYIFFYMHNEIFEEMLKREENAQ
LNSKEVEETLQKE
|
| External Links |
| GenBank ID Protein
| 13603869 |
| UniProtKB/Swiss-Prot ID
| Q9BXU7 |
| UniProtKB/Swiss-Prot Entry Name
| UBP26_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF285593 |
| GeneCard ID
| USP26 |
| GenAtlas ID
| USP26 |
| HGNC ID
| HGNC:13485 |
| References |
| General References
| Not Available |