| Identification |
|---|
| HMDB Protein ID
| CDBP04624 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ubiquitin carboxyl-terminal hydrolase 46 |
| Description
| Not Available |
| Synonyms
|
- Deubiquitinating enzyme 46
- Ubiquitin thiolesterase 46
- Ubiquitin-specific-processing protease 46
|
| Gene Name
| USP46 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ubiquitin thiolesterase activity |
| Specific Function
| Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2 |
| GO Classification
|
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| ubiquitin thiolesterase activity |
| thiolester hydrolase activity |
| Process |
| modification-dependent protein catabolic process |
| ubiquitin-dependent protein catabolic process |
| metabolic process |
| catabolic process |
| macromolecule catabolic process |
| cellular macromolecule catabolic process |
| modification-dependent macromolecule catabolic process |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4q12 |
| SNPs
| USP46 |
| Gene Sequence
|
>1101 bp
ATGACTGTCCGAAACATCGCCTCCATCTGTAATATGGGCACCAATGCCTCTGCTCTGGAA
AAAGACATTGGTCCAGAGCAGTTTCCAATCAATGAACACTATTTCGGATTGGTCAATTTT
GGAAACACATGCTACTGTAACTCCGTGCTTCAGGCATTGTACTTCTGCCGTCCATTCCGG
GAGAATGTGTTGGCATACAAGGCCCAGCAAAAGAAGAAGGAAAACTTGCTGACGTGCCTG
GCGGACCTTTTCCACAGCATTGCCACACAGAAGAAGAAGGTTGGCGTCATCCCACCAAAG
AAGTTCATTTCAAGGCTGAGAAAAGAGAATGATCTCTTTGATAACTACATGCAGCAGGAT
GCTCATGAATTTTTAAATTATTTGCTAAACACTATTGCGGACATCCTTCAGGAGGAGAAG
AAACAGGAAAAACAAAATGGAAAATTAAAAAATGGCAACATGAACGAACCTGCGGAAAAT
AATAAACCAGAACTCACCTGGGTCCATGAGATTTTTCAGGGAACGCTTACCAATGAAACT
CGATGCTTGAACTGTGAAACTGTTAGTAGCAAAGATGAAGATTTTCTTGACCTTTCTGTT
GATGTGGAGCAGAATACATCCATTACCCACTGTCTAAGAGACTTCAGCAACACAGAAACA
CTGTGTAGTGAACAAAAATATTATTGTGAAACATGCTGCAGCAAACAAGAAGCCCAGAAA
AGGATGAGGGTAAAAAAGCTGCCCATGGTCTTGGCCCTGCACCTAAAGCGGTTCAAGTAC
ATGGAGCAGCTGCGCAGATACACCAAGCTGTCTTACCGTGTGGTCTTCCCTCTGGAACTC
CGGCTCTTCAACACCTCCAGTGATGCAGTGAACCTGGACCGCATGTATGACTTGGTTGCG
GTGGTCGTTCACTGTGGCAGTGGTCCTAATCGTGGGCATTATATCACTATTGTGAAAAGT
CACGGCTTCTGGCTTTTGTTTGATGATGACATTGTAGAGAAAATAGATGCTCAAGCTATT
GAAGAATTCTATGGCCTGACGTCAGATATATCAAAAAATTCAGAATCTGGATATATTTTA
TTCTATCAGTCAAGAGAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 366 |
| Molecular Weight
| 42442.1 |
| Theoretical pI
| 6.82 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ubiquitin carboxyl-terminal hydrolase 46
MTVRNIASICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFR
ENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQD
AHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMNEPAENNKPELTWVHEIFQGTLTNET
RCLNCETVSSKDEDFLDLSVDVEQNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQK
RMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELRLFNTSSDAVNLDRMYDLVA
VVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYIL
FYQSRE
|
| External Links |
|---|
| GenBank ID Protein
| 10434108 |
| UniProtKB/Swiss-Prot ID
| P62068 |
| UniProtKB/Swiss-Prot Entry Name
| UBP46_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK022614 |
| GeneCard ID
| USP46 |
| GenAtlas ID
| USP46 |
| HGNC ID
| HGNC:20075 |
| References |
|---|
| General References
| Not Available |