Cannabis Compound Database: Showing Protein Ubiquitin carboxyl-terminal hydrolase 36 (CDBP04622)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP04622

Secondary Accession Numbers

Not Available

Name

Ubiquitin carboxyl-terminal hydrolase 36

Description

Not Available

Synonyms

Deubiquitinating enzyme 36
Ubiquitin thiolesterase 36
Ubiquitin-specific-processing protease 36

Gene Name

USP36

Protein Type

Enzyme

Biological Properties

General Function

Involved in ubiquitin thiolesterase activity

Specific Function

May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4)

GO Classification

Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
ubiquitin thiolesterase activity
thiolester hydrolase activity
Process
ubiquitin-dependent protein catabolic process
metabolic process
catabolic process
macromolecule catabolic process
cellular macromolecule catabolic process
modification-dependent macromolecule catabolic process
modification-dependent protein catabolic process

Cellular Location

Nucleus
nucleolus

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

17q25.3

SNPs

USP36

Gene Sequence

>3372 bp
ATGCCAATAGTGGATAAGTTGAAGGAGGCCCTGAAACCCGGCCGCAAGGACTCGGCTGAT
GATGGAGAACTGGGGAAGCTTCTTGCCTCCTCTGCCAAGAAGGTCCTTTTACAGAAAATC
GAGTTCGAGCCAGCCAGCAAGAGCTTCTCCTACCAGCTGGAGGCCTTAAAGAGCAAATAT
GTGTTGCTCAACCCCAAAACAGAGGGAGCTAGTCGCCACAAGAGTGGAGATGACCCACCG
GCCAGGAGACAGGGCAGTGAGCACACGTATGAGAGCTGTGGTGACGGAGTCCCAGCCCCG
CAGAAAGTGCTTTTCCCCACGGAGCGACTGTCTCTGAGGTGGGAGCGGGTCTTCCGCGTG
GGCGCAGGACTCCACAACCTTGGCAACACCTGCTTTCTCAATGCCACCATCCAGTGCTTG
ACCTACACACCACCTCTAGCCAACTACCTGCTCTCCAAGGAGCATGCTCGCAGCTGCCAC
CAGGGAAGCTTCTGCATGCTGTGTGTCATGCAGAACCACATTGTCCAGGCCTTCGCCAAC
AGCGGCAACGCCATCAAGCCCGTCTCCTTCATCCGAGACCTGAAAAAGATCGCCCGACAC
TTCCGCTTTGGGAACCAGGAGGACGCGCATGAGTTCCTGCGGTACACCATCGACGCCATG
CAGAAAGCCTGCCTGAATGGCTGTGCCAAGTTGGATCGTCAAACGCAGGCTACTACCTTG
GTCCATCAAATTTTTGGAGGGTATCTCAGATCACGCGTGAAGTGCTCCGTGTGCAAGAGC
GTCTCGGACACCTACGACCCCTACTTGGACGTCGCGCTGGAGATCCGGCAAGCTGCGAAT
ATTGTGCGTGCTCTGGAACTTTTTGTGAAAGCAGATGTCCTGAGTGGAGAGAATGCCTAC
ATGTGTGCTAAATGCAAGAAGAAGGTTCCAGCCAGCAAGCGCTTCACCATCCACAGAACA
TCCAACGTCTTAACCCTTTCCCTCAAGCGCTTTGCCAACTTCAGCGGGGGGAAGATCACC
AAGGATGTAGGCTATCCGGAATTCCTCAACATACGTCCGTATATGTCCCAGAATAATGGT
GATCCTGTCATGTATGGACTCTATGCTGTCCTGGTGCACTCGGGCTACAGCTGCCATGCC
GGGCACTATTACTGCTACGTGAAGGCAAGCAATGGACAGTGGTACCAGATGAATGATTCC
TTGGTCCATTCCAGCAACGTCAAGGTGGTTCTGAACCAGCAGGCCTACGTGCTGTTCTAT
CTGCGAATTCCAGGCTCTAAGAAAAGTCCCGAGGGCCTCATCTCCAGGACAGGCTCCTCC
TCCCTTCCCGGCCGCCCGAGTGTGATTCCAGATCACTCCAAGAAGAACATCGGCAATGGG
ATTATTTCCTCCCCACTGACTGGAAAGCGACAAGACTCTGGGACGATGAAGAAGCCGCAC
ACCACTGAAGAGATTGGTGTGCCCATATCCAGGAATGGCTCCACCCTGGGCCTGAAGTCC
CAGAACGGCTGCATTCCTCCAAAGCTGCCCTCGGGGTCCCCTTCCCCCAAACTCTCCCAG
ACACCCACACACATGCCAACCATCCTAGACGACCCTGGAAAGAAGGTGAAGAAGCCAGCT
CCTCCACAGCACTTTTCCCCCAGAACTGCTCAGGGGCTGCCTGGGACCAGCAACTCGAAT
AGCAGCAGATCTGGGAGCCAAAGGCAGGGCTCCTGGGACAGCAGGGATGTTGTCCTCTCT
ACCTCACCTAAGCTCCTGGCTACAGCCACTGCCAACGGGCATGGGCTGAAGGGGAACGAC
GAGAGCGCTGGCCTCGACAGGAGGGGCTCCAGCAGCTCCAGCCCAGAGCACTCGGCCAGC
AGCGACTCCACCAAGGCCCCCCAGACCCCCAGGAGTGGAGCGGCCCATCTCTGCGATTCT
CAGGAAACGAACTGTTCCACCGCTGGCCACTCCAAAACGCCGCCAAGTGGAGCAGATTCT
AAGACGGTGAAGCTGAAGTCCCCTGTCCTGAGCAACACCACCACTGAGCCTGCAAGCACC
ATGTCTCCTCCACCAGCCAAAAAACTGGCCCTTTCTGCCAAGAAGGCCAGCACCCTGTGG
AGGGCGACCGGCAATGACCTCCGTCCACCTCCCCCCTCACCATCCTCCGACCTCACCCAC
CCCATGAAAACCTCTCACCCCGTCGTTGCCTCCACTTGGCCCGTCCATAGAGCCAGGGCT
GTGTCACCTGCTCCCCAATCATCCAGCCGCCTGCAACCCCCCTTCAGCCCCCACCCCACA
TTGCTGTCCAGTACCCCCAAGCCCCCAGGGACGTCAGAACCACGGAGCTGCTCCTCCATC
TCGACGGCGCTGCCTCAGGTCAACGAGGACCTTGTGTCTCTTCCACACCAGTTGCCAGAG
GCCAGTGAGCCCCCCCAGAGCCCCTCTGAGAAGAGGAAAAAGACCTTTGTGGGAGAGCCG
CAGAGGCTGGGCTCAGAGACGCGCCTCCCACAGCACATCAGGGAGGCCACTGCGGCTCCC
CACGGGAAGAGGAAGAGGAAGAAGAAGAAGCGCCCGGAGGACACAGCTGCCAGCGCCCTG
CAGGAGGGGCAGACACAGAGACAGCCTGGGAGCCCCATGTACAGGAGGGAGGGCCAGGCA
CAGCTGCCCGCTGTCAGACGGCAGGAAGATGGCACACAGCCACAGGTGAATGGCCAGCAG
GTGGGATGTGTTACGGACGGCCACCACGCGAGCAGCAGGAAGCGGAGGAGGAAAGGAGCA
GAAGGTCTTGGTGAAGAAGGCGGCCTGCACCAGGACCCACTTCGGCACAGCTGCTCTCCC
ATGGGTGATGGTGATCCAGAGGCCATGGAAGAGTCTCCAAGGAAAAAGAAAAAGAAAAAA
AGAAAGCAGGAGACACAGCGGGCAGTAGAAGAGGATGGGCATCTCAAATGCCCAAGGAGT
GCCAAGCCCCAAGATGCTGTTGTCCCCGAGTCCAGCAGCTGCGCACCATCCGCGAATGGC
TGGTGTCCTGGGGACCGCATGGGGCTGAGCCAGGCCCCTCCTGTGTCTTGGAATGGAGAG
CGGGAGTCTGATGTGGTCCAGGAACTGCTCAAATACTCATCTGATAAAGCTTACGGGAGA
AAAGTTCTGACCTGGGATGGCAAGATGTCGGCGGTCAGTCAGGATGCTATTGAAGACAGC
AGACAGGCCCGGACTGAGACCGTGGTTGATGACTGGGACGAAGAGTTTGACCGAGGGAAG
GAAAAGAAAATTAAAAAATTTAAGAGAGAGAAGAGGAGAAACTTCAACGCCTTCCAGAAA
CTTCAGACTCGACGGAACTTCTGGTCTGTGACTCACCCAGCAAAGGCTGCCAGCCTCAGC
TATCGCCGCTGA

Protein Properties

Number of Residues

1121

Molecular Weight

122650.6

Theoretical pI

10.28

Pfam Domain Function

UCH (PF00443 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Ubiquitin carboxyl-terminal hydrolase 36
MPIVDKLKEALKPGRKDSADDGELGKLLASSAKKVLLQKIEFEPASKSFSYQLEALKSKY
VLLNPKTEGASRHKSGDDPPARRQGSEHTYESCGDGVPAPQKVLFPTERLSLRWERVFRV
GAGLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCHQGSFCMLCVMQNHIVQAFAN
SGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGCAKLDRQTQATTL
VHQIFGGYLRSRVKCSVCKSVSDTYDPYLDVALEIRQAANIVRALELFVKADVLSGENAY
MCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQNNG
DPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFY
LRIPGSKKSPEGLISRTGSSSLPGRPSVIPDHSKKNIGNGIISSPLTGKRQDSGTMKKPH
TTEEIGVPISRNGSTLGLKSQNGCIPPKLPSGSPSPKLSQTPTHMPTILDDPGKKVKKPA
PPQHFSPRTAQGLPGTSNSNSSRSGSQRQGSWDSRDVVLSTSPKLLATATANGHGLKGND
ESAGLDRRGSSSSSPEHSASSDSTKAPQTPRSGAAHLCDSQETNCSTAGHSKTPPSGADS
KTVKLKSPVLSNTTTEPASTMSPPPAKKLALSAKKASTLWRATGNDLRPPPPSPSSDLTH
PMKTSHPVVASTWPVHRARAVSPAPQSSSRLQPPFSPHPTLLSSTPKPPGTSEPRSCSSI
STALPQVNEDLVSLPHQLPEASEPPQSPSEKRKKTFVGEPQRLGSETRLPQHIREATAAP
HGKRKRKKKKRPEDTAASALQEGQTQRQPGSPMYRREGQAQLPAVRRQEDGTQPQVNGQQ
VGCVTDGHHASSRKRRRKGAEGLGEEGGLHQDPLRHSCSPMGDGDPEAMEESPRKKKKRK
QETQRAVEEDGHLKCPRSAKPQDAVVPESSSCAPSANGWCPGDRMGLSQAPPVSWNGERE
SDVVQELLKYSSDKAYGRKVLTWDGKMSAVSQDAIEDSRQARTETVVDDWDEEFDRGKEK
KIKKFKREKRRNFNAFQKLQTRRNFWSVTHPAKAASLSYRR

External Links

GenBank ID Protein

122114651

UniProtKB/Swiss-Prot ID

Q9P275

UniProtKB/Swiss-Prot Entry Name

UBP36_HUMAN

PDB IDs

Not Available

GenBank Gene ID

Not Available

GeneCard ID