| Identification |
|---|
| HMDB Protein ID
| CDBP04619 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ubiquitin carboxyl-terminal hydrolase 47 |
| Description
| Not Available |
| Synonyms
|
- Deubiquitinating enzyme 47
- Ubiquitin thiolesterase 47
- Ubiquitin-specific-processing protease 47
|
| Gene Name
| USP47 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ubiquitin thiolesterase activity |
| Specific Function
| Putative ubiquitin-specific-processing protease that regulates cell growth and survival. Probably regulates CDC25A expression at a transcriptional level. May be catalytically inactive although it seems to have kept all necessary active site residues |
| GO Classification
|
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| ubiquitin thiolesterase activity |
| thiolester hydrolase activity |
| Process |
| modification-dependent protein catabolic process |
| ubiquitin-dependent protein catabolic process |
| metabolic process |
| catabolic process |
| macromolecule catabolic process |
| cellular macromolecule catabolic process |
| modification-dependent macromolecule catabolic process |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11p15.3 |
| SNPs
| USP47 |
| Gene Sequence
|
>3864 bp
ATGGTGCCCGGCGAGGAGAACCAACTGGTCCCGAAAGAGGCACCACTGGATCATACCAGT
GACAAGTCACTTCTCGACGCTAATTTTGAGCCAGGAAAGAAGAACTTTCTGCATTTGACA
GATAAAGATGGTGAACAACCTCAAATACTGCTGGAGGATTCCAGTGCTGGGGAAGACAGT
GTTCATGACAGGTTTATAGGTCCGCTTCCAAGAGAAGGTTCTGGGGGTTCTACCAGTGAT
TATGTCAGCCAAAGCTACTCCTACTCATCTATTTTGAATAAATCAGAAACTGGATATGTG
GGACTAGTAAACCAAGCAATGACTTGCTATTTGAATAGCCTTTTGCAAACACTTTTTATG
ACTCCTGAATTTAGGAATGCATTATATAAGTGGGAATTTGAAGAATCTGAAGAAGATCCA
GTGACAAGTATTCCATACCAACTTCAAAGGCTTTTTGTTTTGTTACAAACCAGCAAAAAG
AGAGCAATTGAAACCACAGATGTTACAAGGAGCTTTGGATGGGATAGTAGTGAGGCTTGG
CAGCAGCATGATGTACAAGAACTATGCAGAGTCATGTTTGATGCTTTGGAACAGAAATGG
AAGCAAACAGAACAGGCTGATCTTATAAATGAGCTATATCAAGGCAAGCTGAAGGACTAC
GTGAGATGTCTGGAATGTGGTTATGAGGGCTGGCGAATCGACACATATCTTGATATTCCA
TTGGTCATCCGACCTTATGGGTCCAGCCAAGCATTTGCTAGTGTGGAAGAAGCATTGCAT
GCATTTATTCAGCCAGAGATTCTGGATGGCCCAAATCAGTATTTTTGTGAACGTTGTAAG
AAGAAGTGTGATGCACGGAAGGGCCTTCGGTTTTTGCATTTTCCTTATCTGCTGACCTTA
CAGCTGAAAAGATTCGATTTTGATTATACAACCATGCATAGGATTAAACTGAATGATCGA
ATGACATTTCCCGAGGAACTAGATATGAGTACTTTTATTGATGTTGAAGATGAGAAATCT
CCTCAGACTGAAAGTTGCACTGACAGTGGAGCAGAAAATGAAGGTAGTTGTCACAGTGAT
CAGATGAGCAACGATTTCTCCAATGATGATGGTGTTGATGAAGGAATCTGTCTTGAAACC
AATAGTGGAACTGAAAAGATCTCAAAATCTGGACTTGAAAAGAATTCCTTGATCTATGAA
CTTTTCTCTGTTATGGTTCATTCTGGGAGCGCTGCTGGTGGTCATTATTATGCATGTATA
AAGTCATTCAGTGATGAGCAGTGGTACAGCTTCAATGATCAACATGTCAGCAGGATAACA
CAAGAGGACATTAAGAAAACACATGGTGGATCTTCAGGAAGCAGAGGATATTATTCTAGT
GCTTTCGCAAGTTCCACAAATGCATATATGCTGATCTATAGACTGAAGGATCCAGCCAGA
AATGCAAAATTTCTAGAAGTGGATGAATACCCAGAACATATTAAAAACTTGGTGCAGAAA
GAGAGAGAGTTGGAAGAACAAGAAAAGAGACAACGAGAAATTGAGCGCAATACATGCAAG
ATAAAATTATTCTGTTTGCATCCTACAAAACAAGTAATGATGGAAAATAAATTGGAGGTT
CATAAGGATAAGACATTAAAGGAAGCAGTAGAAATGGCTTATAAGATGATGGATTTAGAA
GAGGTAATACCCCTGGATTGCTGTCGCCTTGTTAAATATGATGAGTTTCATGATTATCTA
GAACGGTCATATGAAGGAGAAGAAGATACACCAATGGGGCTTCTACTAGGTGGCGTCAAG
TCAACATATATGTTTGATCTGCTGTTGGAGACGAGAAAGCCTGATCAGGTTTTCCAATCT
TATAAACCTGGAGAAGTGATGGTGAAAGTTCATGTTGTTGATCTAAAGGCAGAATCTGTA
GCTGCTCCTATAACTGTTCGTGCTTACTTAAATCAGACAGTTACAGAATTCAAACAACTG
ATTTCAAAGGCCATCCATTTACCTGCTGAAACAATGAGAATAGTGCTGGAACGCTGCTAC
AATGATTTGCGTCTTCTCAGTGTCTCCAGTAAAACCCTGAAAGCTGAAGGATTTTTTAGA
AGTAACAAGGTGTTTGTTGAAAGCTCCGAGACTTTGGATTACCAGATGGCCTTTGCAGAC
TCTCATTTATGGAAACTCCTGGATCGGCATGCAAATACAATCAGATTATTTGTTTTGCTA
CCTGAACAATCCCCAGTATCTTATTCCAAAAGGACAGCATACCAGAAAGCTGGAGGCGAT
TCTGGTAATGTGGATGATGACTGTGAAAGAGTCAAAGGACCTGTAGGAAGCCTAAAGTCT
GTGGAAGCTATTCTAGAAGAAAGCACTGAAAAACTCAAAAGCTTGTCACTGCAGCAACAG
CAGGATGGAGATAATGGGGACAGCAGCAAAAGTACTGAGACAAGTGACTTTGAAAACATC
GAATCACCTCTCAATGAGAGGGACTCTTCAGCATCAGTGGATAATAGAGAACTTGAACAG
CATATTCAGACTTCTGATCCAGAAAATTTTCAGTCTGAAGAACGATCAGACTCAGATGTG
AATAATGACAGGAGTACAAGTTCAGTGGACAGTGATATTCTTAGCTCCAGTCATAGCAGT
GATACTTTGTGCAATGCAGACAATGCTCAGATCCCTTTGGCTAATGGACTTGACTCTCAC
AGTATCACAAGTAGTAGAAGAACGAAAGCAAATGAAGGGAAAAAAGAAACATGGGATACA
GCAGAAGAAGACTCTGGAACTGATAGTGAATATGATGAGAGTGGCAAGAGTAGGGGAGAA
ATGCAGTACATGTATTTCAAAGCTGAACCTTATGCTGCAGATGAAGGTTCTGGGGAAGGA
CATAAATGGTTGATGGTGCATGTTGATAAAAGAATTACTCTGGCAGCTTTCAAACAACAT
TTAGAGCCCTTTGTTGGAGTTTTGTCCTCTCACTTCAAGGTCTTTCGAGTGTATGCCAGC
AATCAAGAGTTTGAGAGCGTCCGGCTGAATGAGACACTTTCATCATTTTCTGATGACAAT
AAGATTACAATTAGACTGGGGAGAGCACTTAAAAAAGGAGAATACAGAGTTAAAGTATAC
CAGCTTTTGGTCAATGAACAAGAGCCATGCAAGTTTCTGCTAGATGCTGTGTTTGCTAAA
GGAATGACTGTACGGCAATCAAAAGAGGAATTAATTCCTCAGCTCAGGGAGCAATGTGGT
TTAGAGCTCAGTATTGACAGGTTTCGTCTAAGGAAAAAAACATGGAAGAATCCTGGCACT
GTCTTTTTGGATTATCATATTTATGAAGAAGATATTAATATTTCCAGCAACTGGGAGGTT
TTCCTTGAAGTTCTTGATGGGGTAGAGAAGATGAAGTCCATGTCACAGCTTGCAGTTTTG
TCAAGACGGTGGAAGCCTTCAGAGATGAAGTTGGATCCCTTCCAGGAGGTTGTATTGGAA
AGCAGTAGTGTGGACGAATTGCGAGAGAAGCTTAGTGAAATCAGTGGGATTCCTTTGGAT
GATATTGAATTTGCTAAGGGTAGAGGAACATTTCCCTGTGATATTTCTGTCCTTGATATT
CATCAGGATTTAGACTGGAATCCTAAAGTTTCTACCCTGAATGTCTGGCCTCTTTATATC
TGTGATGATGGTGCGGTCATATTTTATAGGGATAAAACAGAAGAATTAATGGAATTGACA
GATGAGCAAAGAAATGAACTGATGAAAAAAGAAAGCAGTCGACTCCAGAAGACTGGACAT
CGTGTAACATACTCACCTCGTAAAGAGAAAGCACTAAAAATATATCTGGATGGAGCACCA
AATAAAGATCTGACTCAAGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1375 |
| Molecular Weight
| 157266.9 |
| Theoretical pI
| 4.72 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ubiquitin carboxyl-terminal hydrolase 47
MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVNERI
TLNLPASTPVRKLFEDVANKVGYINGTFDLVWGNGINTADMAPLDHTSDKSLLDANFEPG
KKNFLHLTDKDGEQPQILLEDSSAGEDSVHDRFIGPLPREGSVGSTSDYVSQSYSYSSIL
NKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLF
VLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINEL
YQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDGPN
QYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSTF
IDVEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSNDDGVDEGICLETNSGTEKISKSGL
EKNSLIYELFSVMAHSGSAAGGHYYACIKSFSDEQWYSFDDQHVSRITQEDIKKTHGGSS
GSRGYYSSAFASSTNAYMLIYRLKDPARNAKFLEVGEYPEHIKNLVQKERELEEQEKRQR
EIERNTCKIKLFCLHPTKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEEVIPLDCCRLVK
YDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKPDQVFQSYKPGEVMVKVHV
VDLKAESVAAPITVRAYLNQTVTEFKQLISKAIHLPAETMRIVLERCYNDLRLLSVSSKT
LKAEGFFRSNKVFVESSETLDYQMAFADSHLWKLLDRHANTIRLFVLLPEQSPVSYSKRT
AYQKAGGDSGNVDDDCERVKGPVGSLKSVEAILEESTEKLKSLSLQQQQDGDNGDSSKST
ETSDFENIESPLNERDSSASVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSD
ILSSSHSSDTLCNADNAQIPLANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYD
ESGKSRGEMQYMYFKAEPYAADEGSGEGHKWLMVHVDKRITLAAFKQHLEPFVGVLSSHF
KVFRVYASNQEFESVRLNETLSSFSDDNKITIRLGRALKKGEYRVKVYQLLVNEQEPCKF
LLDAVFAKGMTVRQSKEELIPQLREQCGLELSIDRFRLRKKTWKNPGTVFLDYHIYEEDI
NISSNWEVFLEVLDGVEKMKSMSQLAVLSRRWKPSEMKLDPFQEVVLESSSVDELREKLS
EISGIPLDDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDK
TEELMELTDEQRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDLTQD
|
| External Links |
|---|
| GenBank ID Protein
| 71774197 |
| UniProtKB/Swiss-Prot ID
| Q96K76 |
| UniProtKB/Swiss-Prot Entry Name
| UBP47_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| USP47 |
| GenAtlas ID
| USP47 |
| HGNC ID
| HGNC:20076 |
| References |
|---|
| General References
| Not Available |