| Identification |
|---|
| HMDB Protein ID
| CDBP04614 |
| Secondary Accession Numbers
| Not Available |
| Name
| STAM-binding protein |
| Description
| Not Available |
| Synonyms
|
- Associated molecule with the SH3 domain of STAM
- Endosome-associated ubiquitin isopeptidase
|
| Gene Name
| STAMBP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in metal ion binding |
| Specific Function
| Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- Peripheral membrane protein
- Membrane
- Early endosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2p13.1 |
| SNPs
| STAMBP |
| Gene Sequence
|
>1275 bp
ATGTCTGACCATGGAGATGTGAGCCTCCCGCCCGAAGACCGGGTGAGGGCTCTCTCCCAG
CTGGGTAGTGCGGTAGAGGTGAATGAAGACATTCCACCCCGTCGGTACTTCCGCTCTGGA
GTTGAGATTATCCGAATGGCATCCATTTACTCTGAGGAAGGCAACATTGAACATGCCTTC
ATCCTCTATAACAAGTATATCACGCTCTTTATTGAGAAACTACCAAAACATCGAGATTAC
AAATCTGCTGTCATTCCTGAAAAGAAAGACACAGTAAAGAAATTAAAGGAGATTGCATTT
CCCAAAGCAGAAGAGCTGAAGGCAGAGCTGTTAAAACGATATACCAAAGAATATACAGAA
TATAATGAAGAAAAGAAGAAGGAAGCAGAGGAATTGGCCCGGAACATGGCCATCCAGCAA
GAGCTGGAAAAGGAAAAACAGAGGGTAGCACAACAGAAGCAGCAGCAATTGGAACAGGAA
CAGTTCCATGCCTTCGAGGAGATGATCCGGAACCAGGAGCTAGAAAAAGAGCGACTGAAA
ATTGTACAGGAGTTTGGGAAGGTAGACCCTGGCCTAGGTGGCCCGCTAGTGCCTGACTTG
GAGAAGCCCTCCTTAGATGTGTTCCCCACCTTAACAGTCTCATCCATACAGCCTTCAGAC
TGTCACACAACTGTAAGGCCAGCTAAGCCACCTGTGGTGGACAGGTCCTTGAAACCTGGA
GCACTGAGCAACTCAGAAAGTATTCCCACAATCGATGGATTGCGCCATGTGGTGGTGCCT
GGGCGGCTGTGCCCACAGTTTCTCCAGTTAGCCAGTGCCAACACTGCCCGGGGAGTGGAG
ACATGTGGAATTCTCTGTGGAAAACTGATGAGGAATGAATTTACCATTACCCATGTTCTC
ATCCCCAAGCAAAGTGCTGGGTCTGATTACTGCAACACAGAGAACGAAGAAGAACTTTTC
CTCATACAGGATCAGCAGGGCCTCATCACACTGGGCTGGATTCATACTCACCCCACACAG
ACCGCGTTTCTCTCCAGTGTCGACCTACACACTCACTGCTCTTACCAGATGATGTTGCCA
GAGTCAGTAGCCATTGTTTGCTCCCCCAAGTTCCAGGAAACTGGATTCTTTAAACTAACT
GACCATGGACTAGAGGAGATTTCTTCCTGTCGCCAGAAAGGATTTCATCCACACAGCAAG
GATCCACCTCTGTTCTGTAGCTGCAGCCACGTGACTGTTGTGGACAGAGCAGTGACCATC
ACAGACCTTCGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 424 |
| Molecular Weight
| 48076.5 |
| Theoretical pI
| 6.24 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>STAM-binding protein
MSDHGDVSLPPEDRVRALSQLGSAVEVNEDIPPRRYFRSGVEIIRMASIYSEEGNIEHAF
ILYNKYITLFIEKLPKHRDYKSAVIPEKKDTVKKLKEIAFPKAEELKAELLKRYTKEYTE
YNEEKKKEAEELARNMAIQQELEKEKQRVAQQKQQQLEQEQFHAFEEMIRNQELEKERLK
IVQEFGKVDPGLGGPLVPDLEKPSLDVFPTLTVSSIQPSDCHTTVRPAKPPVVDRSLKPG
ALSNSESIPTIDGLRHVVVPGRLCPQFLQLASANTARGVETCGILCGKLMRNEFTITHVL
IPKQSAGSDYCNTENEEELFLIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLP
ESVAIVCSPKFQETGFFKLTDHGLEEISSCRQKGFHPHSKDPPLFCSCSHVTVVDRAVTI
TDLR
|
| External Links |
|---|
| GenBank ID Protein
| 62630163 |
| UniProtKB/Swiss-Prot ID
| O95630 |
| UniProtKB/Swiss-Prot Entry Name
| STABP_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AC073046 |
| GeneCard ID
| STAMBP |
| GenAtlas ID
| STAMBP |
| HGNC ID
| HGNC:16950 |
| References |
|---|
| General References
| Not Available |