| Identification |
|---|
| HMDB Protein ID
| CDBP04612 |
| Secondary Accession Numbers
| Not Available |
| Name
| Carboxymethylenebutenolidase homolog |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| CMBL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin.
|
| GO Classification
|
| Cellular Component |
| cytosol |
| Function |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| hydrolase activity |
|
| Cellular Location
|
- Cytoplasm
- cytosol
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| CMBL |
| Gene Sequence
|
>738 bp
ATGGCTAACGAAGCTTATCCTTGTCCGTGTGACATTGGCCACAGACTTGAGTATGGAGGG
CTAGGCCGTGAAGTTCAAGTCGAGCACATCAAGGCTTATGTCACCAAATCCCCCGTTGAT
GCAGGCAAAGCTGTGATTGTCATTCAAGATATATTTGGCTGGCAGTTGCCCAATACCAGA
TATATAGCTGACATGATCTCAGGAAATGGATACACAACCATTGTTCCAGACTTCTTTGTA
GGGCAAGAGCCTTGGGACCCCTCTGGCGACTGGTCTATCTTCCCTGAGTGGCTGAAAACA
AGAAATGCCCAGAAGATCGATAGAGAGATCAGTGCTATCTTGAAGTATCTGAAACAACAG
TGTCATGCCCAGAAAATTGGCATCGTGGGATTCTGCTGGGGTGGAACTGCTGTCCATCAT
TTGATGATGAAATACTCAGAATTCAGGGCAGGGGTGTCCGTCTATGGCATTGTCAAGGAT
TCTGAAGACATTTACAATTTAAAGAACCCCACTTTGTTCATTTTTGCTGAAAATGATGTT
GTGATTCCACTCAAGGACGTATCTTTGCTGACTCAGAAGTTGAAAGAACACTGCAAAGTT
GAATATCAAATTAAAACATTTTCTGGGCAGACTCATGGGTTCGTGCATCGGAAGAGAGAA
GATTGCTCACCTGCAGACAAGCCCTACATTGACGAGGCCAGAAGGAATTTAATTGAGTGG
CTGAACAAGTACATGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 245 |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Carboxymethylenebutenolidase homolog
MANEAYPCPCDIGHRLEYGGLGREVQVEHIKAYVTKSPVDAGKAVIVIQDIFGWQLPNTR
YIADMISGNGYTTIVPDFFVGQEPWDPSGDWSIFPEWLKTRNAQKIDREISAILKYLKQQ
CHAQKIGIVGFCWGGTAVHHLMMKYSEFRAGVSVYGIVKDSEDIYNLKNPTLFIFAENDV
VIPLKDVSLLTQKLKEHCKVEYQIKTFSGQTHGFVHRKREDCSPADKPYIDEARRNLIEW
LNKYM
|
| External Links |
|---|
| GenBank ID Protein
| 27526513 |
| UniProtKB/Swiss-Prot ID
| Q96DG6 |
| UniProtKB/Swiss-Prot Entry Name
| CMBL_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ278125 |
| GeneCard ID
| CMBL |
| GenAtlas ID
| CMBL |
| HGNC ID
| HGNC:25090 |
| References |
|---|
| General References
| Not Available |