| Identification |
|---|
| HMDB Protein ID
| CDBP04610 |
| Secondary Accession Numbers
| Not Available |
| Name
| D-dopachrome decarboxylase |
| Description
| Not Available |
| Synonyms
|
- D-dopachrome tautomerase
- Phenylpyruvate tautomerase II
|
| Gene Name
| DDT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in D-dopachrome decarboxylase activity |
| Specific Function
| Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).
|
| GO Classification
|
| Biological Process |
| melanin biosynthetic process |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| D-dopachrome decarboxylase activity |
| dopachrome isomerase activity |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| 22q11.23 |
| SNPs
| DDT |
| Gene Sequence
|
>357 bp
ATGCCGTTCCTGGAGCTGGACACGAATTTGCCCGCCAACCGAGTGCCCGCGGGGCTGGAG
AAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAACCTGCGGACCGCGTGAACGTG
ACGGTACGGCCGGGCCTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTG
TCCATCTCCTCCATCGGCGTAGTGGGCACCGCCGAGGACAACCGCAGCCACAGCGCCCAC
TTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGGACCGGATACTTATCCGCTTT
TTCCCCTTGGAGTCCTGGCAGATTGGCAAGATAGGGACGGTCATGACTTTTTTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 118 |
| Molecular Weight
| 12711.605 |
| Theoretical pI
| 7.295 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>D-dopachrome decarboxylase
MPFLELDTNLPANRVPAGLEKRLCAAAASILGKPADRVNVTVRPGLAMALSGSTEPCAQL
SISSIGVVGTAEDNRSHSAHFFEFLTKELALGQDRILIRFFPLESWQIGKIGTVMTFL
|
| External Links |
|---|
| GenBank ID Protein
| 2352915 |
| UniProtKB/Swiss-Prot ID
| P30046 |
| UniProtKB/Swiss-Prot Entry Name
| DOPD_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF012434 |
| GeneCard ID
| DDT |
| GenAtlas ID
| DDT |
| HGNC ID
| HGNC:2732 |
| References |
|---|
| General References
| Not Available |