| Identification |
|---|
| HMDB Protein ID
| CDBP04605 |
| Secondary Accession Numbers
| Not Available |
| Name
| Receptor-type tyrosine-protein phosphatase H |
| Description
| Not Available |
| Synonyms
|
- R-PTP-H
- SAP-1
- Stomach cancer-associated protein tyrosine phosphatase 1
- Transmembrane-type protein-tyrosine phosphatase type H
|
| Gene Name
| PTPRH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| May contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of p130cas, focal adhesion kinase and c-Src. Reduces migratory activity of Jurkat cells.
|
| GO Classification
|
| Biological Process |
| apoptotic process |
| Cellular Component |
| nucleus |
| integral to plasma membrane |
| mitochondrion |
| Function |
| phosphoprotein phosphatase activity |
| protein tyrosine phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| Molecular Function |
| transmembrane receptor protein tyrosine phosphatase activity |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Cytoplasm
- Membrane
- Single-pass type I membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19q13.4 |
| SNPs
| PTPRH |
| Gene Sequence
|
>3348 bp
ATGGCTGGGGCTGGCGGGGGCCTCGGGGTCTGGGGGAACCTGGTGCTGCTGGGCCTGTGC
AGCTGGACAGGGGCCAGGGCGCCTGCCCCCAACCCAGGGAGGAACCTGACAGTGGAGACT
CAGACCACCAGCTCCATCTCCCTGAGCTGGGAGGTCCCCGATGGCCTAGACTCACAGAAC
TCCAACTACTGGGTTCAGTGTACTGGAGACGGCGGCACAACAGAGACTCGAAACACAACA
GCCACCAACGTCACCGTGGATGGCCTTGGACCCGGGTCATTGTATACGTGTTCTGTGTGG
GTGGAGAAAGACGGAGTAAATAGCTCTGTGGGGACTGTCACTACTGCCACAGCTCCCAAC
CCAGTGAGGAACCTGAGAGTGGAGGCTCAGACCAACAGCTCCATCGCCCTGACCTGGGAG
GTCCCCGACGGCCCAGACCCACAGAACTCCACCTACGGGGTTGAGTACACTGGAGATGGT
GGCAGAGCAGGGACTCGAAGCACAGCACACACTAACATCACCGTGGATGGACTTGAACCC
GGGTGTTTGTATGCGTTTTCCATGTGGGTGGGAAAGAATGGAATCAACAGCTCCCGGGAG
ACTCGAAATGCCACCACAGCTCACAACCCAGTGAGGAACCTGAGAGTGGAGGCTCAGACC
ACCAGCTCCATCTCCCTGAGCTGGGAGGTCCCCGATGGCACAGACCCACAGAACTCGACC
TACTGCGTTCAGTGCACTGGAGATGGTGGCAGAACAGAGACTCGAAACACAACAGACACC
AGAGTCACCGTGGATGGCCTTGGACCCGGGTCATTGTATACGTGTTCTGTGTGGGTGGAG
AAAGACGGAGTAAATAGCTCTGTGGAGATTGTCACTAGTGCCACAGCTCCCAACCCAGTG
AGAAACCTGACAGTGGAGGCTCAGACCAACAGCTCCATCGCCCTGACCTGGGAGGTCCCC
GATGGCCCAGACCCACAGAACTCCACCTACGGGGTTGAGTACACTGGAGATGGTGGCAGA
GCAGGGACTCGAAGCACAGCACACACCAACATCACCGTGGATAGACTTGAACCCGGGTGT
TTGTATGTGTTTTCCGTGTGGGTGGGGAAGAATGGAATCAACAGCTCCCGGGAGACTCGA
AATGCCACCACAGCCCCCAACCCAGTGAGAAACCTCCATATGGAGACTCAGACCAACAGC
TCCATCGCCCTATGCTGGGAAGTCCCCGATGGCCCATACCCTCAGGACTACACCTACTGG
GTAGAGTACACTGGAGACGGTGGTGGCACAGAGACCCGAAACACAACAAATACCAGTGTG
ACAGCTGAGAGACTTGAGCCCGGAACCTTGTACACATTCTCTGTATGGGCAGAAAAAAAT
GGAGCACGTGGCTCCAGGCAGAATGTCAGCATCTCCACAGTCCCCAACGCAGTGACAAGC
CTCAGCAAGCAGGACTGGACCAACAGCACCATTGCTTTGCGCTGGACAGCTCCCCAGGGC
CCAGGCCAGTCTTCCTACAGCTACTGGGTCTCATGGGTCAGGGAAGGCATGACTGACCCC
AGGACCCAAAGCACCTCAGGTACTGACATCACCCTAAAGGAACTGGAAGCTGGCAGCCTG
TACCACCTCACCGTCTGGGCCGAGAGGAATGAGGTCAGAGGCTATAACAGCACCCTCACT
GCAGCCACTGCTCCCAATGAGGTCACAGATCTCCAGAATGAAACTCAGACTAAGAACTCA
GTCATGCTGTGGTGGAAGGCCCCTGGAGACCCCCACTCTCAGTTGTACGTATACTGGGTC
CAGTGGGCCAGCAAGGGACATCCCCGGAGGGGGCAAGATCCCCAAGCGAATTGGGTCAAC
CAGACCAGCAGGACCAATGAGACGTGGTACAAAGTGGAGGCCCTGGAACCCGGGACGTTG
TACAATTTCACCGTGTGGGCAGAGAGGAATGACGTAGCCAGTTCCACGCAGAGCCTCTGT
GCGTCCACATACCCAGACACAGTCACCATCACTTCCTGTGTCAGCACCTCAGCGGGCTAT
GGAGTCAACTTGATCTGGTCCTGCCCCCAGGGAGGCTACGAGGCCTTTGAGTTGGAGGTG
GGAGGACAGCGGGGCTCCCAGGACAGATCTTCATGTGGGGAGGCTGTGTCTGTGTTGGGT
CTCGGGCCGGCTCGGTCCTACCCAGCCACCATCACGACCATCTGGGACGGAATGAAGGTC
GTGTCTCACTCTGTGGTCTGCCACACCGAGAGTGCAGGGGTCATTGCCGGAGCCTTTGTG
GGCATCCTCCTGTTTCTCATCCTCGTGGGCCTGCTGATTTTCTTCCTGAAGAGGAGGAAT
AAGAAGAAGCAGCAGAAACCAGAACTCAGGGATCTGGTCTTTAGCTCCCCAGGGGACATC
CCAGCTGAAGACTTCGCTGACCACGTCAGGAAGAATGAGAGGGACAGCAACTGTGGTTTT
GCAGACAAGTACCAGCAACTCTCCCTGGTGGGCCACAGCCAGTCTCAGATGGTGGCTTCG
GCTTCAGAGAACAACGCCAAGAACCGCTACAGAAATGTGCTGCCCTATGACTGGTCCCGG
GTGCCCCTGAAGCCCATCCATGAGGAGCCAGGCTCTGACTACATCAATGCCAGCTTCATG
CCCGGTCTCTGGAGCCCCCAGGAGTTCATTGCAACCCAGGGTCCCCTGCCACAGACAGTG
GGTGACTTCTGGCGCCTGGTGTGGGAACAGCAGAGCCACACCCTGGTCATGCTGACCAAC
TGCATGGAGGCCGGCCGGGTGAAGTGTGAGCATTACTGGCCTCTGGACTCGCAGCCCTGC
ACCCATGGGCACCTGCGGGTAACCCTGGTAGGTGAGGAAGTGATGGAGAACTGGACGGTG
CGGGAACTGCTGCTCCTCCAGGTGGAGGAGCAGAAGACACTGTCTGTGCGCCAATTCCAC
TACCAGGCCTGGCCGGATCACGGCGTTCCCTCCTCCCCAGACACCTTGCTGGCTTTCTGG
AGGATGCTTCGGCAGTGGCTGGATCAGACCATGGAGGGAGGCCCACCCATTGTGCACTGC
AGTGCTGGCGTGGGTCGCACAGGAACCCTCATTGCCCTGGACGTCCTGCTCCGGCAGCTG
CAGTCCGAGGGTCTCCTTGGGCCCTTCAGCTTTGTAAGGAAGATGAGAGAGAGTCGGCCG
TTGATGGTGCAGACTGAGGCTCAGTACGTATTCCTGCATCAGTGCATCCTGCGGTTCCTC
CAACAGTCAGCCCAGGCCCCAGCCGAGAAGGAAGTCCCGTATGAGGATGTCGAAAACCTC
ATCTACGAGAACGTGGCCGCCATCCAGGCCCACAAGTTGGAGGTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1115 |
| Molecular Weight
| 103411.89 |
| Theoretical pI
| 5.513 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Receptor-type tyrosine-protein phosphatase H
MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQN
SNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPN
PVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEP
GCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNST
YCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPV
RNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGC
LYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYW
VEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTS
LSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSL
YHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWV
QWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLC
ASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLG
LGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKRRN
KKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVAS
ASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTV
GDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTV
RELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHC
SAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL
QQSAQAPAEKEVPYEDVENLIYENVAAIQAHKLEV
|
| External Links |
|---|
| GenBank ID Protein
| 241896924 |
| UniProtKB/Swiss-Prot ID
| Q9HD43 |
| UniProtKB/Swiss-Prot Entry Name
| PTPRH_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_002842.3 |
| GeneCard ID
| PTPRH |
| GenAtlas ID
| PTPRH |
| HGNC ID
| HGNC:9672 |
| References |
|---|
| General References
| Not Available |