| Identification |
|---|
| HMDB Protein ID
| CDBP04598 |
| Secondary Accession Numbers
| Not Available |
| Name
| Carboxypeptidase D |
| Description
| Not Available |
| Synonyms
|
- Metallocarboxypeptidase D
- gp180
|
| Gene Name
| CPD |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in carboxypeptidase activity |
| Specific Function
| Releases C-terminal Arg and Lys from polypeptides |
| GO Classification
|
| Function |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| exopeptidase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| hydrolase activity |
| transition metal ion binding |
| zinc ion binding |
| serine-type carboxypeptidase activity |
| metallocarboxypeptidase activity |
| carboxypeptidase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| protein metabolic process |
| proteolysis |
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17q11.2 |
| SNPs
| CPD |
| Gene Sequence
|
>4143 bp
ATGGCGAGCGGCCGGGACGAGCGGCCGCCTTGGCGGCTAGGGCGGCTCCTGTTGCTCATG
TGCCTGCTGCTGCTGGGGAGCTCGGCCCGGGCGGCTCACATCAAGGAGGCGGAGGCGACT
ACCACAACTACGAGCGCGGGCGCCGAGGCGGCCGAGGGCCAGTTCGACCGCTACTACCAC
GAAGAGGAGTTGGAGTCGGCGCTGAGGGAGGCGGCGGCCGCGGGCCTCCCCGGCCTGGCC
CGCCTCTTTAGCATCGGCCGCTCGGTGGAAGGCCGGCCGCTGTGGGTGCTTCGCCTCACC
GCAGGCCTGGGGTCGCTAATCCCTGAGGGCGACGCGGGGCCTGACGCTGCCGGGCCCGAC
GCTGCGGGGCCGCTGCTGCCCGGCCGGCCCCAGGTGAAGCTGGTGGGCAACATGCATGGC
GACGAGACCGTGTCGCGCCAGGTGTTGATCTACTTGGCCCGCGAGCTGGCGGCCGGCTAC
CGCCGCGGGGACCCGCGCCTGGTCCGCCTGCTCAACACCACCGACGTGTACCTGCTGCCC
AGCCTCAACCCCGATGGCTTCGAGCGTGCCCGCGAGGGCGACTGTGGCTTCGGCGACGGC
GGCCCGTCCGGGGCCAGCGGCCGCGACAATAGTCGCGGCCGCGACCTCAACCGAAGCTTT
CCCGACCAGTTTAGCACCGGCGAACCCCCCGCCCTGGACGAGGTGCCCGAGGTGCGCGCC
CTCATCGAGTGGATCCGCAGGAACAAGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCA
GTGGTAGCAAGCTATCCTTTTGATGATTCTCCAGAACATAAGGCCACTGGAATCTATAGC
AAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAAGCTTATGCTTCAAACCACCCC
ATAATGAAAACTGGTGAGCCTCATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGA
ATCACAAACGGCGCACATTGGTATGATGTGGAAGGTGGTATGCAAGATTACAATTATGTG
TGGGCCAACTGTTTTGAGATCACATTAGAACTGTCTTGTTGCAAGTACCCACCTGCTTCA
CAGCTTCGACAGGAATGGGAGAACAATCGTGAGTCTTTGATCACATTGATTGAAAAGGTT
CACATTGGAGTGAAAGGATTTGTTAAAGATTCCATAACAGGATCTGGGTTAGAGAATGCA
ACCATCTCAGTGGCTGGTATTAATCATAATATCACAACAGGCAGATTTGGTGATTTCTAC
CGATTACTTGTTCCTGGAACTTACAACCTTACAGTAGTTTTAACTGGGTATATGCCATTG
ACTGTTACTAATGTAGTGGTGAAAGAAGGACCAGCCACAGGGGTGGATTTTTCTCTTAGG
CCAACTGTAACTTCAGTAATCCCTGACACGACAGAGGCTGTATCAACTGCTAGCACAGTT
GCTATACCTAATATTCTTTCTGGAACATCATCCTCCTACCAGCCAATTCAGCCAAAGGAC
TTTCACCACCACAATTTCCCTGATATGGAAATCTTCTTGAGAAGGTTTGCCAATGAATAT
CCTAACATTACCCGGCTTTATTCCTTGGGAAAATCAGTAGAGTCAAGAGAACTTTATGTG
ATGGAGATATCTGATAATCCGGGTGTCCATGAACCAGGTGAACCAGAATTTAAGTACATT
GGAAATATGCATGGAAATGAAGTGGTTGGAAGAGAACTGCTGTTGAACCTCATAGAATAC
CTTTGTAAGAACTTTGGAACAGACCCTGAAGTCACAGATTTGGTTCATAACACTAGAATT
CACCTTATGCCATCCATGAATCCTGATGGGTATGAAAAGTCCCAGGAAGGAGATTCAATA
AGTGTAATTGGCAGAAACAACAGCAACAACTTTGACCTGAACCGAAATTTCCCAGACCAG
TTTGTTCAGATCACAGATCCTACGCAACCAGAAACTATTGCTGTAATGAGCTGGATGAAG
TCCTATCCATTTGTACTTTCAGCAAACCTGCATGGAGGTTCTTTGGTGGTTAACTACCCT
TTTGATGATGATGAACAAGGACTTGCCACATATAGTAAATCACCAGATGATGCTGTGTTC
CAACAAATAGCACTTTCTTATTCCAAGGAAAATTCCCAGATGTTTCAAGGTAGACCTTGC
AAGAATATGTATCCTAATGAATATTTTCCTCATGGAATAACAAATGGAGCTAGTTGGTAT
AATGTGCCAGGAGGAATGCAGGACTGGAACTATTTACAAACAAATTGCTTTGAAGTGACT
ATTGAACTAGGTTGTGTGAAATATCCACTTGAGAAAGAGCTGCCAAACTTTTGGGAACAG
AATCGAAGATCACTAATCCAGTTTATGAAACAGGTTCATCAGGGCGTCAGAGGATTTGTT
CTAGATGCCACAGATGGCAGGGGTATATTAAATGCCACCATTAGTGTTGCTGAGATTAAT
CACCCAGTGACTACTTACAAAACTGGAGATTACTGGCGTCTCTTGGTTCCAGGAACTTAT
AAAATCACAGCATCTGCTCGAGGGTATAATCCAGTTACCAAGAATGTGACTGTCAAGAGT
GAAGGCGCTATTCAGGTCAACTTCACACTTGTTCGATCCTCAACAGATTCAAACAATGAA
TCAAAGAAAGGAAAAGGGGCTAGCAGCAGCACCAATGATGCCAGTGATCCAACTACTAAA
GAGTTTGAAACTTTAATTAAAGACCTTTCAGCGGAGAATGGTTTGGAAAGCCTCATGTTA
CGCTCCTCCTCAAATCTGGCTCTGGCTCTTTATCGATACCATTCCTACAAAGACTTATCA
GAGTTTCTGAGAGGACTTGTAATGAACTATCCACATATTACAAATCTTACCAATTTGGGA
CAGAGCACTGAATATCGTCACATTTGGTCCCTTGAAATCTCCAATAAGCCCAATGTATCT
GAGCCTGAAGAACCAAAGATTCGTTTTGTTGCTGGTATCCATGGAAATGCGCCAGTTGGA
ACTGAACTGCTTTTGGCTCTGGCAGAATTTCTCTGCCTGAACTACAAAAAGAACCCAGCT
GTTACCCAATTGGTTGACAGGACTAGGATTGTGATTGTCCCTTCTCTAAATCCAGATGGG
CGAGAGAGAGCTCAAGAGAAAGACTGTACTTCAAAAATAGGACAAACAAATGCTCGTGGC
AAAGATTTGGATACAGACTTCACAAATAATGCCTCCCAACCTGAGACCAAAGCCATCATT
GAAAATTTGATTCAAAAACAGGACTTTAGTCTTTCTGTTGCCTTAGATGGTGGTTCCATG
CTGGTCACATATCCTTATGACAAGCCAGTACAGACAGTGGAAAATAAAGAGACTCTGAAG
CATTTGGCATCTCTTTATGCAAATAATCATCCATCCATGCACATGGGTCAGCCCAGTTGC
CCAAATAAATCAGATGAGAATATTCCAGGAGGAGTAATGCGTGGAGCAGAATGGCATAGT
CACCTGGGCAGCATGAAGGATTATAGTGTCACCTATGGCCATTGTCCGGAAATCACAGTA
TACACAAGCTGCTGTTACTTTCCTAGTGCTGCACGACTCCCTTCCTTGTGGGCAGACAAT
AAGAGATCTCTTCTTAGTATGTTAGTGGAGGTTCACAAGGGAGTTCATGGATTTGTTAAA
GATAAGACTGGAAAGCCAATCTCTAAAGCAGTCATTGTACTTAATGAAGGAATAAAGGTA
CAAACAAAAGAGGGAGGTTATTTCCATGTACTCTTAGCGCCAGGTGTCCATAACATTATT
GCCATCGCTGATGGGTACCAGCAACAACATTCACAGGTCTTTGTGCATCATGATGCAGCT
AGTTCTGTGGTGATAGTCTTTGACACAGATAACCGGATATTTGGTTTGCCAAGGGAGCTT
GTGGTAACTGTATCAGGTGCTACTATGTCGGCATTGATCCTAACAGCTTGCATTATTTGG
TGCATCTGCTCAATCAAGTCTAATAGACACAAGGATGGCTTTCATCGGCTCAGGCAGCAT
CATGATGAGTATGAAGATGAAATTCGCATGATGTCTACCGGCTCCAAGAAGTCCCTCCTA
AGCCATGAGTTCCAGGATGAAACAGACACTGAAGAGGAAACATTATATTCTAGCAAACAT
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 1380 |
| Molecular Weight
| 152929.9 |
| Theoretical pI
| 5.95 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Carboxypeptidase D
MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYH
EEELESALREAAAAGLPGLARLFSIGRSVEGRPLWVLRLTAGLGSLIPEGDAGPDAAGPD
AAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLP
SLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRA
LIEWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHP
IMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPAS
QLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFY
RLLVPGTYNLTVVLTGYMPLTVTNVVVKEGPATEVDFSLRPTVTSVIPDTTEAVSTASTV
AIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYV
MEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVHNTRI
HLMPSMNPDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQPETIAVMSWMK
SYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDDAVFQQIALSYSKENSQMFQGRPC
KNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPLEKELPNFWEQ
NRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINHPVTTYKTGDYWRLLVPGTY
KITASARGYNPVTKNVTVKSEGAIQVNFTLVRSSTDSNNESKKGKGASSSTNDASDPTTK
EFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFLRGLVMNYPHITNLTNLG
QSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNYKKNPA
VTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFTNNASQPETKAII
ENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMGQPSC
PNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAARLPSLWADN
KRSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIKVQTKEGGYFHVLLAPGVHNII
AIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALILTACIIW
CICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH
|
| External Links |
|---|
| GenBank ID Protein
| 28374245 |
| UniProtKB/Swiss-Prot ID
| O75976 |
| UniProtKB/Swiss-Prot Entry Name
| CBPD_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC045549 |
| GeneCard ID
| CPD |
| GenAtlas ID
| CPD |
| HGNC ID
| HGNC:2301 |
| References |
|---|
| General References
| Not Available |