| Identification |
|---|
| HMDB Protein ID
| CDBP04597 |
| Secondary Accession Numbers
| Not Available |
| Name
| Carboxypeptidase B2 |
| Description
| Not Available |
| Synonyms
|
- CPU
- Carboxypeptidase U
- Plasma carboxypeptidase B
- TAFI
- Thrombin-activable fibrinolysis inhibitor
- pCPB
|
| Gene Name
| CPB2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in metallocarboxypeptidase activity |
| Specific Function
| Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities |
| GO Classification
|
| Function |
| catalytic activity |
| hydrolase activity |
| transition metal ion binding |
| zinc ion binding |
| metallocarboxypeptidase activity |
| carboxypeptidase activity |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| exopeptidase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| Process |
| metabolic process |
| macromolecule metabolic process |
| protein metabolic process |
| proteolysis |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 13q14.11 |
| SNPs
| CPB2 |
| Gene Sequence
|
>1272 bp
ATGAAGCTTTGCAGCCTTGCAGTCCTTGTACCCATTGTTCTCTTCTGTGAGCAGCATGTC
TTCGCGTTTCAGAGTGGCCAAGTTCTAGCTGCTCTTCCTAGAACCTCTAGGCAAGTTCAA
GTTCTACAGAATCTTACTACAACATATGAGATTGTTCTCTGGCAGCCGGTAACAGCTGAC
CTTATTGTGAAGAAAAAACAAGTCCATTTTTTTGTAAATGCATCTGATGTCGACAATGTG
AAAGCCCATTTAAATGTGAGCGGAATTCCATGCAGTGTCTTGCTGGCAGATGTGGAAGAT
CTTATTCAACAGCAGATTTCCAACGACACAGTCAGCCCCCGAGCCTCCGCATCGTACTAT
GAACAGTATCACTCACTAAATGAAATCTATTCTTGGATAGAATTTATAACTGAGAGGCAT
CCTGATATGCTTACAAAAATCCACATTGGATCCTCATTTGAGAAGTACCCACTCTATGTT
TTAAAGGTTTCTGGAAAAGAACAAGCAGCCAAAAATGCCATATGGATTGACTGTGGAATC
CATGCCAGAGAATGGATCTCTCCTGCTTTCTGCTTGTGGTTCATAGGCCATATAACTCAA
TTCTATGGGATAATAGGGCAATATACCAATCTCCTGAGGCTTGTGGATTTCTATGTTATG
CCAGTGGTTAATGTGGATGGTTATGACTACTCATGGAAAAAGAATCGAATGTGGAGAAAG
AACCGTTCTTTCTATGCGAACAATCATTGCATCGGAACAGACCTGAATAGGAACTTTGCT
TCCAAACACTGGTGTGAGGAAGGTGCATCCAGTTCCTCATGCTCGGAAACCTACTGTGGA
CTTTATCCTGAGTCAGAACCAGAAGTGAAGGCAGTGGCTAGTTTCTTGAGAAGAAATATC
AACCAGATTAAAGCATACATCAGCATGCATTCATACTCCCAGCATATAGTGTTTCCATAT
TCCTATACACGAAGTAAAAGCAAAGACCATGAGGAACTGTCTCTAGTAGCCAGTGAAGCA
GTTCGTGCTATTGAGAAAACTAGTAAAAATACCAGGTATACACATGGCCATGGCTCAGAA
ACCTTATACCTAGCTCCTGGAGGTGGGGACGATTGGATCTATGATTTGGGCATCAAATAT
TCGTTTACAATTGAACTTCGAGATACGGGCACATACGGATTCTTGCTGCCGGAGCGTTAC
ATCAAACCCACCTGTAGAGAAGCTTTTGCCGCTGTCTCTAAAATAGCTTGGCATGTCATT
AGGAATGTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 423 |
| Molecular Weight
| 48411.8 |
| Theoretical pI
| 7.77 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Carboxypeptidase B2
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKTSKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV
|
| External Links |
|---|
| GenBank ID Protein
| 126273569 |
| UniProtKB/Swiss-Prot ID
| Q96IY4 |
| UniProtKB/Swiss-Prot Entry Name
| CBPB2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001872.3 |
| GeneCard ID
| CPB2 |
| GenAtlas ID
| CPB2 |
| HGNC ID
| HGNC:2300 |
| References |
|---|
| General References
| Not Available |