| Identification |
| HMDB Protein ID
| CDBP04530 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dual serine/threonine and tyrosine protein kinase |
| Description
| Not Available |
| Synonyms
|
- Dusty PK
- Dusty protein kinase
- RIP-homologous kinase
- Receptor-interacting serine/threonine-protein kinase 5
- SgK496
- Sugen kinase 496
|
| Gene Name
| DSTYK |
| Protein Type
| Enzyme |
| Biological Properties |
| General Function
| Involved in protein kinase activity |
| Specific Function
| May induce both caspase-dependent apoptosis and caspase- independent cell death |
| GO Classification
|
| Function |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| protein kinase activity |
| protein serine/threonine kinase activity |
| binding |
| catalytic activity |
| transferase activity |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| metabolic process |
| cellular metabolic process |
| protein amino acid phosphorylation |
| phosphorylation |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q32.1 |
| SNPs
| DSTYK |
| Gene Sequence
|
>2790 bp
ATGGAGGGCGACGGGGTGCCATGGGGCAGCGAGCCCGTCTCGGGTCCCGGCCCCGGCGGC
GGCGGAATGATCCGCGAGCTGTGCCGGGGCTTCGGCCGCTACCGCCGCTACCTGGGACGG
CTGCGACAGAACCTGCGCGAGACCCAGAAGTTCTTCCGCGACATCAAGTGCTCCCACAAC
CACACTTGTCTCTCCTCCCTCACGGGCGGCGGCGGGGCCGAGCGCGGCCCTGCAGGCGAT
GTCGCCGAAACCGGGCTGCAGGCGGGCCAACTGAGCTGCATTTCCTTCCCACCTAAGGAA
GAGAAGTACCTCCAGCAGATTGTGGACTGCCTCCCTTGCATACTGATCCTCGGCCAGGAT
TGTAACGTCAAGTGCCAGCTGTTGAATCTGCTGTTGGGGGTGCAGGTGCTTCCCACCACC
AAGCTGGGCAGTGAGGAGAGCTGTAAGCTTCGGCGCCTCCGCTTCACCTATGGGACTCAG
ACTCGGGTCAGCCTGGCGCTCCCTGGACAGTATGAACTAGTGCACACGCTGGTTGCTCAT
CAGGGCAACTGGGAGACCATCCCTGAGGAGGATCTGGAGGTCCAAGAGAACAATGAGGAT
GCTGCTCATGTTTTAGCGGAACTGGAGGTAACGATGCACCATGCTCTCTTACAGGAAGTG
GACGTTGTGGTAGCACCATGCCAAGGCCTCCGGCCCACAGTGGATGTTCTGGGTGACTTG
GTGAATGATTTCTTGCCTGTGATAACCTATGCACTCCACAAAGATGAACTCTCTGAGAGG
GATGAGCAAGAGCTTCAGGAAATCCGAAAGTATTTCTCCTTTCCTGTATTCTTTTTCAAA
GTGCCGAAACTGGGCTCGGAGATAATAGACTCCTCAACCAGGAGAATGGAGAGCGAAAGA
TCACCGCTTTATCGCCAGCTAATTGACCTGGGCTATCTGAGCAGCAGTCACTGGAACTGT
GGGGCTCCTGGCCAGGATACTAAAGCTCAGAGCATGTTGGTGGAACAGAGTGAAAAGCTG
AGACACTTGAGCACATTTTCTCACCAGGTGTTACAGACTCGCCTGGTGGATGCAGCCAAG
GCCCTGAACCTGGTGCACTGCCACTGCCTTGACATCTTTATTAACCAGGCATTTGACATG
CAGCGGGACCTGCAGATCACTCCCAAACGTCTGGAATATACTCGAAAAAAGGAGAATGAG
TTGTATGAATCATTGATGAATATTGCCAACCGAAAGCAGGAGGAAATGAAGGATATGATT
GTTGAGACACTTAATACCATGAAGGAGGAACTTCTGGATGATGCTACTAACATGGAGTTT
AAAGACGTCATTGTCCCTGAGAATGGAGAACCAGTAGGCACCAGAGAGATCAAATGCTGC
ATCCGACAGATCCAGGAACTCATCATCTCCCGACTTAATCAGGCAGTGGCTAATAAGCTG
ATCAGCTCAGTGGATTACCTGAGGGAAAGCTTCGTCGGAACCCTGGAACGATGTCTGCAG
AGCCTGGAGAAGTCTCAGGATGTCTCAGTTCACATCACCAGTAATTATCTCAAACAGATC
TTAAATGCTGCCTATCATGTTGAAGTCACGTTTCACTCAGGGTCGTCAGTTACAAGGATG
CTATGGGAGCAAATCAAACAGATCATCCAGCGCATCACATGGGTGAGCCCACCTGCCATC
ACTCTGGAATGGAAGAGGAAGGTGGCCCAGGAAGCCATTGAGAGCCTCAGCGCCTCCAAA
TTGGCTAAGAGCATTTGCAGCCAATTCCGGACTCGGCTCAATAGTTCCCACGAGGCTTTT
GCAGCCTCCTTGCGGCAGCTGGAAGCTGGCCACTCAGGCCGGTTAGAGAAAACGGAAGAT
CTATGGCTGAGGGTTCGGAAAGATCATGCTCCCCGCCTGGCCCGCCTTTCTCTGGAAAGC
TGTTCTTTACAGGATGTCTTGCTTCATCGTAAACCTAAACTGGGACAGGAACTGGGCCGG
GGCCAGTATGGTGTGGTATACCTGTGTGACAACTGGGGAGGACACTTCCCTTGTGCCCTC
AAATCAGTTGTCCCTCCAGATGAGAAGCACTGGAATGATCTGGCTTTGGAATTTCACTAT
ATGAGGTCTCTGCCGAAGCATGAGCGATTGGTGGATCTCCATGGTTCAGTCATTGACTAC
AACTATGGTGGTGGCTCCAGCATTGCTGTGCTCCTCATTATGGAGCGGCTACACCGGGAT
CTCTACACAGGGCTGAAGGCTGGGCTGACCCTGGAGACACGTTTGCAGATAGCACTAGAT
GTGGTGGAGGGAATCCGCTTCCTGCACAGCCAGGGACTTGTCCATCGTGATATCAAACTG
AAAAATGTGCTGCTGGATAAGCAGAACCGTGCCAAGATCACTGACTTAGGATTCTGCAAG
CCAGAGGCCATGATGTCAGGCAGCATTGTGGGGACACCAATCCATATGGCCCCTGAACTT
TTCACAGGGAAGTACGATAATTCCGTGGATGTCTACGCTTTTGGAATTCTTTTCTGGTAT
ATCTGCTCAGGCTCTGTCAAGCTCCCTGAGGCATTTGAGAGGTGTGCTAGCAAAGACCAT
CTCTGGAACAATGTGCGGAGGGGGGCTCGCCCAGAACGTCTTCCTGTGTTTGATGAGGAG
TGCTGGCAGTTGATGGAAGCCTGTTGGGATGGCGACCCCTTGAAGAGGCCTCTCTTGGGC
ATTGTCCAGCCCATGCTCCAGGGCATCATGAATCGGCTCTGCAAGTCCAATTCTGAGCAG
CCAAACAGAGGACTAGATGATTCTACTTGA
|
| Protein Properties |
| Number of Residues
| 929 |
| Molecular Weight
| 105204.7 |
| Theoretical pI
| 6.72 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dual serine/threonine and tyrosine protein kinase
MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHN
HTCLSSLTGGGGAERGPAGDVAETGLQAGQLSCISFPPKEEKYLQQIVDCLPCILILGQD
CNVKCQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAH
QGNWETIPEEDLEVQENNEDAAHVLAELEVTMHHALLQEVDVVVAPCQGLRPTVDVLGDL
VNDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDSSTRRMESER
SPLYRQLIDLGYLSSSHWNCGAPGQDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDAAK
ALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMI
VETLNTMKEELLDDATNMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKL
ISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRM
LWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAF
AASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGR
GQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDY
NYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKL
KNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWY
ICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLG
IVQPMLQGIMNRLCKSNSEQPNRGLDDST
|
| External Links |
| GenBank ID Protein
| 40806179 |
| UniProtKB/Swiss-Prot ID
| Q6XUX3 |
| UniProtKB/Swiss-Prot Entry Name
| DUSTY_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_015375.2 |
| GeneCard ID
| DSTYK |
| GenAtlas ID
| DSTYK |
| HGNC ID
| HGNC:29043 |
| References |
| General References
| Not Available |