Showing Protein Inositol-pentakisphosphate 2-kinase (CDBP04507)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 4 compounds
Identification
HMDB Protein ID CDBP04507
Secondary Accession Numbers Not Available
Name Inositol-pentakisphosphate 2-kinase
Description Not Available
Synonyms
  1. IPK1 homolog
  2. Inositol-1,3,4,5,6-pentakisphosphate 2-kinase
  3. Ins(1,3,4,5,6)P5 2-kinase
  4. InsP5 2-kinase
Gene Name IPPK
Protein Type Enzyme
Biological Properties
General Function Involved in ATP binding
Specific Function Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.
GO Classification
Biological Process
inositol phosphorylation
Cellular Component
intracellular
cytoplasm
nucleus
Function
adenyl ribonucleotide binding
atp binding
inositol or phosphatidylinositol kinase activity
binding
catalytic activity
inositol pentakisphosphate 2-kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
Molecular Function
ATP binding
inositol pentakisphosphate 2-kinase activity
Cellular Location
  1. Nucleus
  2. Cytoplasm
Pathways
Gene Properties
Chromosome Location 9
Locus 9q22.31
SNPs IPPK
Gene Sequence 
>1476 bp
ATGGAAGAGGGGAAGATGGACGAGAATGAATGGGGGTACCACGGAGAGGGCAATAAGAGC
CTGGTGGTGGCCCACGCGCAGCGCTGCGTCGTGCTGCGGTTTCTGAAGTTTCCTCCAAAT
AGGAAGAAGACCTCGGAAGAGATATTTCAACACCTGCAGAACATAGTGGACTTTGGGAAA
AATGTCATGAAGGAGTTTTTGGGGGAGAACTATGTTCATTATGGGGAGGTCGTTCAGCTA
CCTTTAGAGTTTGTGAAACAGCTTTGTTTAAAGATACAATCTGAAAGACCAGAGTCTCGC
TGTGACAAGGACCTGGATACTCTCAGTGGTTACGCTATGTGCCTTCCTAATTTAACCAGA
CTCCAAACCTACCGCTTTGCAGAGCACCGGCCGATTCTGTGTGTAGAGATTAAGCCAAAA
TGTGGGTTTATTCCTTTCTCGAGTGATGTCACGCATGAGATGAAGCATAAGGTCTGTCGA
TACTGCATGCACCAGCACCTCAAGGTAGCAACTGGGAAGTGGAAGCAGATCAGCAAATAC
TGTCCCCTTGATCTCTACTCAGGAAACAAACAGAGAATGCACTTTGCCTTGAAGAGTTTG
CTGCAGGAGGCACAGAACAACTTGAAGATATTTAAGAATGGTGAGCTGATTTACGGCTGC
AAAGATGCCCGGAGCCCCGTGGCTGACTGGAGCGAGCTTGCACACCACCTGAAGCCGTTC
TTCTTCCCTTCCAACGGCCTGGCCAGTGGGCCCCACTGCACAAGGGCTGTGATCAGGGAG
CTGGTGCACGTGATCACACGGGTGCTGCTGAGTGGCTCGGACAAGGGCCGGGCAGGCACC
CTGAGTCCGGGGCTCGGGCCTCAGGGCCCGCGAGTCTGCGAAGCCAGCCCTTTCAGTAGG
AGCCTTCGCTGCCAAGGAAAAAACACCCCAGAGCGCTCGGGGTTACCGAAGGGCTGTCTT
CTGTACAAAACCCTCCAGGTGCAGATGTTGGACCTGCTGGACATCGAAGGCCTCTACCCT
CTGTACAACCGGGTTGAGCGATACCTGGAAGAGTTTCCCGAGGAGAGAAAAACCTTACAA
ATAGATGGGCCTTATGATGAAGCATTTTACCAGAAGCTGCTTGACCTTTCCACTGAGGAT
GACGGGACAGTGGCCTTCGCGCTAACGAAGGTGCAGCAGTACCGCGTCGCCATGACTGCC
AAGGACTGCTCCATCATGATTGCACTGTCTCCCTGTCTGCAGGATGCCAGCTCTGATCAA
AGGCCTGTCGTCCCTTCATCGAGGTCCAGGTTTGCCTTTTCCGTGTCTGTGCTGGACCTT
GACCTCAAGCCCTACGAGAGCATTCCCCATCAGTATAAACTGGACGGCAAGATCGTCAAC
TATTATTCAAAGACTGTACGTGCCAAAGACAACGCCGTGATGTCGACTCGGTTCAAGGAA
AGCGAAGATTGCACATTAGTTCTCCACAAGGTCTAA
Protein Properties
Number of Residues 491
Molecular Weight 56016.12
Theoretical pI 8.364
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Inositol-pentakisphosphate 2-kinase
MEEGKMDENEWGYHGEGNKSLVVAHAQRCVVLRFLKFPPNRKKTSEEIFQHLQNIVDFGK
NVMKEFLGENYVHYGEVVQLPLEFVKQLCLKIQSERPESRCDKDLDTLSGYAMCLPNLTR
LQTYRFAEHRPILCVEIKPKCGFIPFSSDVTHEMKHKVCRYCMHQHLKVATGKWKQISKY
CPLDLYSGNKQRMHFALKSLLQEAQNNLKIFKNGELIYGCKDARSPVADWSELAHHLKPF
FFPSNGLASGPHCTRAVIRELVHVITRVLLSGSDKGRAGTLSPGLGPQGPRVCEASPFSR
SLRCQGKNTPERSGLPKGCLLYKTLQVQMLDLLDIEGLYPLYNRVERYLEEFPEERKTLQ
IDGPYDEAFYQKLLDLSTEDDGTVAFALTKVQQYRVAMTAKDCSIMIALSPCLQDASSDQ
RPVVPSSRSRFAFSVSVLDLDLKPYESIPHQYKLDGKIVNYYSKTVRAKDNAVMSTRFKE
SEDCTLVLHKV
GenBank ID Protein 14582858
UniProtKB/Swiss-Prot ID Q9H8X2
UniProtKB/Swiss-Prot Entry Name IPPK_HUMAN
PDB IDs Not Available
GenBank Gene ID AF351202
GeneCard ID IPPK
GenAtlas ID IPPK
HGNC ID HGNC:14645
References
General References Not Available