| Identification |
|---|
| HMDB Protein ID
| CDBP04500 |
| Secondary Accession Numbers
| Not Available |
| Name
| Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 |
| Description
| Not Available |
| Synonyms
|
- NLI-IF
- NLI-interacting factor 3
- Nuclear LIM interactor-interacting factor 3
- SCP1
- Small C-terminal domain phosphatase 1
- Small CTD phosphatase 1
|
| Gene Name
| CTDSP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
|
| GO Classification
|
| Biological Process |
| regulation of transcription from RNA polymerase II promoter |
| negative regulation of neurogenesis |
| negative regulation of neuron differentiation |
| protein dephosphorylation |
| Cellular Component |
| nucleus |
| Function |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| metal ion binding |
| CTD phosphatase activity |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2q35 |
| SNPs
| CTDSP1 |
| Gene Sequence
|
>786 bp
ATGGACAGCTCGGCCGTCATTACTCAGATCAGCAAGGAGGAGGCTCGGGGCCCGCTGCGG
GGCAAAGGTGACCAGAAGTCAGCAGCTTCCCAGAAGCCCCGAAGCCGGGGCATCCTCCAC
TCACTCTTCTGCTGTGTCTGCCGGGATGATGGGGAGGCCCTGCCTGCTCACAGCGGGGCG
CCCCTGCTTGTGGAGGAGAATGGAGCCATCCCTAAGCAGACCCCAGTCCAATACCTGCTC
CCTGAGGCCAAGGCCCAGGACTCAGACAAGATCTGCGTGGTCATCGACCTGGACGAGACC
CTGGTGCACAGCTCCTTCAAGCCAGTGAACAACGCGGACTTCATCATCCCTGTGGAGATT
GATGGGGTGGTCCACCAGGTCTACGTGTTGAAGCGTCCTCACGTGGATGAGTTCCTGCAG
CGAATGGGCGAGCTCTTTGAATGTGTGCTGTTCACTGCTAGCCTCGCCAAGTACGCAGAC
CCAGTAGCTGACCTGCTGGACAAATGGGGGGCCTTCCGGGCCCGGCTGTTTCGAGAGTCC
TGCGTCTTCCACCGGGGGAACTACGTGAAGGACCTGAGCCGGTTGGGTCGAGACCTGCGG
CGGGTGCTCATCCTGGACAATTCACCTGCCTCCTATGTCTTCCATCCAGACAATGCTGTA
CCGGTGGCCTCGTGGTTTGACAACATGAGTGACACAGAGCTCCACGACCTCCTCCCCTTC
TTCGAGCAACTCAGCCGTGTGGACGACGTGTACTCAGTGCTCAGGCAGCCACGGCCAGGG
AGCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 261 |
| Molecular Weight
| 29127.765 |
| Theoretical pI
| 5.508 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGA
PLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEI
DGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRES
CVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPF
FEQLSRVDDVYSVLRQPRPGS
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9GZU7 |
| UniProtKB/Swiss-Prot Entry Name
| CTDS1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF229162 |
| GeneCard ID
| CTDSP1 |
| GenAtlas ID
| CTDSP1 |
| HGNC ID
| HGNC:21614 |
| References |
|---|
| General References
| Not Available |