Showing Protein Dual specificity protein phosphatase 14 (CDBP04497)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP04497
Secondary Accession Numbers Not Available
Name Dual specificity protein phosphatase 14
Description Not Available
Synonyms
  1. MAP kinase phosphatase 6
  2. MKP-1-like protein tyrosine phosphatase
  3. MKP-6
  4. MKP-L
  5. Mitogen-activated protein kinase phosphatase 6
Gene Name DUSP14
Protein Type Enzyme
Biological Properties
General Function Involved in phosphatase activity
Specific Function Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.
GO Classification
Biological Process
peptidyl-tyrosine dephosphorylation
Function
phosphatase activity
map kinase tyrosine/serine/threonine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
Molecular Function
protein tyrosine/serine/threonine phosphatase activity
MAP kinase tyrosine/serine/threonine phosphatase activity
protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Cytoplasmic
Pathways
Gene Properties
Chromosome Location 17
Locus 17q12
SNPs DUSP14
Gene Sequence 
>597 bp
ATGAGCTCCAGAGGTCACAGCACGCTACCAAGGACTCTCATGGCCCCTCGGATGATTTCC
GAGGGAGACATAGGAGGCATTGCTCAAATCACCTCCTCTCTATTCCTGGGCAGAGGCAGT
GTGGCCTCCAATCGGCACCTCCTCCAGGCTCGTGGCATCACCTGCATTGTTAATGCTACC
ATTGAGATCCCTAATTTCAACTGGCCCCAATTTGAGTATGTTAAAGTGCCTCTGGCTGAC
ATGCCGCATGCCCCCATTGGACTGTACTTTGACACCGTGGCTGACAAGATCCACAGTGTG
AGCAGGAAGCACGGGGCCACCTTGGTGCACTGTGCTGCAGGGGTGAGCCGCTCAGCCACG
CTGTGTATCGCGTACCTGATGAAATTCCACAACGTGTGCCTGCTGGAGGCATACAACTGG
GTGAAAGCCCGGCGACCTGTCATCAGGCCCAACGTAGGCTTCTGGAGGCAACTGATAGAC
TACGAGCGCCAGCTCTTTGGGAAGTCGACAGTTAAAATGGTACAGACACCTTATGGCATA
GTTCCCGACGTCTATGAGAAGGAGTCCCGACACCTGATGCCTTACTGGGGGATTTAG
Protein Properties
Number of Residues 198
Molecular Weight 22254.755
Theoretical pI 9.565
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Dual specificity protein phosphatase 14
MSSRGHSTLPRTLMAPRMISEGDIGGIAQITSSLFLGRGSVASNRHLLQARGITCIVNAT
IEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSAT
LCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGKSTVKMVQTPYGI
VPDVYEKESRHLMPYWGI
GenBank ID Protein 4104681
UniProtKB/Swiss-Prot ID O95147
UniProtKB/Swiss-Prot Entry Name DUS14_HUMAN
PDB IDs
GenBank Gene ID AF038844
GeneCard ID DUSP14
GenAtlas ID DUSP14
HGNC ID HGNC:17007
References
General References Not Available