| Identification |
|---|
| HMDB Protein ID
| CDBP04489 |
| Secondary Accession Numbers
| Not Available |
| Name
| Gamma-glutamylcyclotransferase |
| Description
| Not Available |
| Synonyms
|
- Cytochrome c-releasing factor 21
|
| Gene Name
| GGCT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acyltransferase activity |
| Specific Function
| Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.
|
| GO Classification
|
| Biological Process |
| xenobiotic metabolic process |
| glutathione biosynthetic process |
| release of cytochrome c from mitochondria |
| Cellular Component |
| cytosol |
| Molecular Function |
| protein homodimerization activity |
| gamma-glutamylcyclotransferase activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glutathione Metabolism |    |  | | Glutathione Synthetase Deficiency |    | Not Available | | 5-Oxoprolinuria |    | Not Available | | Gamma-Glutamyltransferase Deficiency |    | Not Available | | 5-oxoprolinase deficiency |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7p15-p14 |
| SNPs
| GGCT |
| Gene Sequence
|
>567 bp
ATGGCCAACTCGGGCTGCAAGGACGTCACGGGTCCAGATGAGGAGAGTTTTCTGTACTTT
GCCTACGGCAGCAACCTGCTGACAGAGAGGATCCACCTCCGAAACCCCTCGGCGGCGTTC
TTCTGTGTGGCCCGCCTGCAGGATTTTAAGCTTGACTTTGGCAATTCCCAAGGCAAAACA
AGTCAAACTTGGCATGGAGGGATAGCCACCATTTTTCAGAGTCCTGGCGATGAAGTGTGG
GGAGTAGTATGGAAAATGAACAAAAGCAATTTAAATTCTCTGGATGAGCAAGAAGGGGTT
AAAAGTGGAATGTATGTTGTAATAGAAGTTAAAGTTGCAACTCAAGAAGGAAAAGAAATA
ACCTGTCGAAGTTATCTGATGACAAATTACGAAAGTGCTCCCCCATCCCCACAGTATAAA
AAGATTATTTGCATGGGTGCAAAAGAAAATGGTTTGCCGCTGGAGTATCAAGAGAAGTTA
AAAGCAATAGAACCAAATGACTATACAGGAAAGGTCTCAGAAGAAATTGAAGACATCATC
AAAAAGGGGGAAACACAAACTCTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 188 |
| Molecular Weight
| 19091.635 |
| Theoretical pI
| 9.493 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Gamma-glutamylcyclotransferase
MANSGCKDVTGPDEESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNSQGKT
SQTWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEQEGVKSGMYVVIEVKVATQEGKEI
TCRSYLMTNYESAPPSPQYKKIICMGAKENGLPLEYQEKLKAIEPNDYTGKVSEEIEDII
KKGETQTL
|
| External Links |
|---|
| GenBank ID Protein
| 189054993 |
| UniProtKB/Swiss-Prot ID
| O75223 |
| UniProtKB/Swiss-Prot Entry Name
| GGCT_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK315608 |
| GeneCard ID
| GGCT |
| GenAtlas ID
| GGCT |
| HGNC ID
| HGNC:21705 |
| References |
|---|
| General References
| Not Available |