Showing Protein Peptidoglycan recognition protein 4 (CDBP04478)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP04478
Secondary Accession Numbers Not Available
Name Peptidoglycan recognition protein 4
Description Not Available
Synonyms
  1. Peptidoglycan recognition protein I-beta
  2. Peptidoglycan recognition protein intermediate beta
  3. PGLYRPIbeta
  4. PGRP-I-beta
Gene Name PGLYRP4
Protein Type Enzyme
Biological Properties
General Function Not Available
Specific Function Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.
GO Classification
Biological Process
detection of bacterium
growth of symbiont in host
negative regulation of interferon-gamma production
negative regulation of natural killer cell differentiation involved in immune response
peptidoglycan catabolic process
defense response to Gram-positive bacterium
innate immune response
Cellular Component
intracellular
extracellular region
membrane
Function
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
n-acetylmuramoyl-l-alanine amidase activity
binding
catalytic activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
protein binding
Molecular Function
N-acetylmuramoyl-L-alanine amidase activity
peptidoglycan binding
peptidoglycan receptor activity
zinc ion binding
Process
cellular carbohydrate metabolism
peptidoglycan metabolism
peptidoglycan catabolism
physiological process
metabolism
macromolecule metabolism
carbohydrate metabolism
Cellular Location
  1. Cytoplasmic
Pathways
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Q5SY64
Gene Sequence 
>1122 bp
ATGCTGCCGTGGCTTCTTGTCTTCTCTGCTCTGGGTATCCAGGCCTGGGGTGATTCCTCC
TGGAACAAAACACAAGCTAAACAGGTATCAGAGGGGCTCCAGTACCTATTTGAGAACATC
TCCCAGCTCACTGAAAAAGGCCTTCCCACAGATGTCTCCACCACGGTCTCTCGCAAGGCA
TGGGGGGCAGAAGCTGTTGGCTGCAGTATTCAGCTGACCACGCCAGTGAATGTCCTTGTT
ATACACCATGTCCCTGGACTGGAGTGTCACGACCAGACAGTCTGCAGCCAGAGACTGCGG
GAACTGCAGGCCCATCATGTCCACAACAACAGTGGGTGTGATGTGGCCTACAACTTCCTG
GTTGGGGATGATGGCAGGGTGTATGAAGGTGTTGGCTGGAATATCCAAGGAGTGCACACC
CAAGGCTACAACAACATCTCCCTGGGCTTTGCCTTCTTTGGCACTAAGAAAGGCCACAGT
CCCAGCCCTGCTGCCCTGTCGGCCATGGAAAACCTAATCACCTATGCTGTCCAGAAGGGC
CACCTGTCATCCAGTTATGTTCAGCCACTTCTTGGGAAAGGCGAGAACTGCCTGGCCCCT
CGGCAGAAGACAAGCCTGAAGAAGGCTTGCCCCGGCGTTGTCCCACGGTCTGTGTGGGGA
GCCAGGGAGACCCACTGTCCCAGGATGACTCTCCCAGCGAAGTATGGCATCATTATCCAC
ACTGCCGGGAGGACCTGCAACATTTCTGATGAGTGCCGCCTGCTGGTCCGGGACATCCAG
TCTTTCTACATAGACAGGCTCAAGTCATGCGACATTGGTTATAACTTCCTGGTGGGCCAG
GATGGCGCCATTTATGAAGGGGTGGGCTGGAATGTCCAAGGCTCCTCCACCCCTGGCTAC
GATGACATTGCCCTGGGCATTACCTTCATGGGCACCTTCACAGGTATACCACCCAATGCT
GCAGCACTAGAGGCAGCCCAAGACCTGATCCAGTGTGCCATGGTCAAAGGGTACCTGACT
CCCAACTACCTGCTGGTGGGCCACAGTGATGTGGCCCGAACCTTGTCTCCTGGGCAGGCT
TTGTACAACATCATCAGCACCTGGCCTCATTTCAAACACTGA
Protein Properties
Number of Residues 373
Molecular Weight Not Available
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Peptidoglycan recognition protein 4 (PGLYRP4 protein)
MLPWLLVFSALGIQAWGDSSWNKTQAKQVSEGLQYLFENISQLTEKGLPTDVSTTVSRKA
WGAEAVGCSIQLTTPVNVLVIHHVPGLECHDQTVCSQRLRELQAHHVHNNSGCDVAYNFL
VGDDGRVYEGVGWNIQGVHTQGYNNISLGFAFFGTKKGHSPSPAALSAMENLITYAVQKG
HLSSSYVQPLLGKGENCLAPRQKTSLKKACPGVVPRSVWGARETHCPRMTLPAKYGIIIH
TAGRTCNISDECRLLVRDIQSFYIDRLKSCDIGYNFLVGQDGAIYEGVGWNVQGSSTPGY
DDIALGITFMGTFTGIPPNAAALEAAQDLIQCAMVKGYLTPNYLLVGHSDVARTLSPGQA
LYNIISTWPHFKH
GenBank ID Protein 148744335
UniProtKB/Swiss-Prot ID Q96LB8
UniProtKB/Swiss-Prot Entry Name Q5SY64_HUMAN
PDB IDs
GenBank Gene ID BC142636
GeneCard ID Q5SY64
GenAtlas ID PGLYRP4
HGNC ID HGNC:30015
References
General References Not Available