| Identification |
|---|
| HMDB Protein ID
| CDBP04477 |
| Secondary Accession Numbers
| Not Available |
| Name
| Peptidoglycan recognition protein 3 |
| Description
| Not Available |
| Synonyms
|
- PGLYRPIalpha
- PGRP-I-alpha
- Peptidoglycan recognition protein I-alpha
- Peptidoglycan recognition protein intermediate alpha
|
| Gene Name
| PGLYRP3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in N-acetylmuramoyl-L-alanine amidase activity |
| Specific Function
| Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.
|
| GO Classification
|
| Biological Process |
| detection of bacterium |
| growth of symbiont in host |
| negative regulation of interferon-gamma production |
| negative regulation of natural killer cell differentiation involved in immune response |
| peptidoglycan catabolic process |
| defense response to Gram-positive bacterium |
| innate immune response |
| Cellular Component |
| intracellular |
| extracellular region |
| membrane |
| Function |
| n-acetylmuramoyl-l-alanine amidase activity |
| binding |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| protein binding |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| Molecular Function |
| N-acetylmuramoyl-L-alanine amidase activity |
| peptidoglycan binding |
| peptidoglycan receptor activity |
| zinc ion binding |
| Process |
| glycosaminoglycan metabolic process |
| peptidoglycan metabolic process |
| peptidoglycan catabolic process |
| metabolic process |
| primary metabolic process |
| carbohydrate metabolic process |
| polysaccharide metabolic process |
| aminoglycan metabolic process |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| PGLYRP3 |
| Gene Sequence
|
>1026 bp
ATGGGGACGCTGCCATGGCTTCTTGCCTTCTTCATTCTGGGTCTCCAGGCTTGGGATACT
CCCACCATCGTCTCCCGCAAGGAGTGGGGGGCAAGACCGCTCGCCTGCAGGGCCCTGCTG
ACCCTGCCTGTGGCCTACATCATCACAGACCAGCTCCCAGGGATGCAGTGCCAGCAGCAG
AGCGTTTGCAGCCAGATGCTGCGGGGGTTGCAGTCCCATTCCGTCTACACCATAGGCTGG
TGCGACGTGGCGTACAACTTCCTGGTTGGGGATGATGGCAGGGTGTATGAAGGTGTTGGC
TGGAACATCCAAGGCTTGCACACCCAGGGCTACAACAACATTTCCCTGGGCATCGCCTTC
TTTGGCAATAAGATAGGCAGCAGTCCCAGCCCTGCTGCCTTATCAGCTGCAGAGGGTCTG
ATCTCCTATGCCATCCAGAAGGGTCACCTGTCGCCCAGGTATATTCAGCCACTTCTTCTG
AAAGAAGAGACCTGCCTGGACCCTCAACATCCAGTGATGCCCAGGAAGGTTTGCCCCAAC
ATCATCAAACGATCTGCTTGGGAAGCCAGAGAGACACACTGCCCTAAAATGAACCTCCCA
GCCAAATATGTCATCATCATCCACACCGCTGGCACAAGCTGCACTGTATCCACAGACTGC
CAGACTGTCGTCCGAAACATACAGTCCTTTCACATGGACACACGGAACTTTTGTGACATT
GGATATCACTTCCTGGTGGGCCAGGATGGTGGCGTGTATGAAGGGGTTGGATGGCACATC
CAAGGCTCTCACACTTATGGATTCAACGATATTGCCCTAGGAATTGCCTTCATCGGCTAC
TTTGTAGAAAAGCCTCCAAATGCTGCAGCGCTGGAGGCGGCCCAGGACCTGATCCAGTGT
GCCGTGGTTGAGGGGTACCTGACTCCAAACTACCTGCTGATGGGCCACAGTGACGTGGTC
AACATCCTGTCCCCTGGGCAGGCTTTGTATAACATCATCAGCACCTGGCCTCATTTCAAG
CACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 341 |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Peptidoglycan recognition protein 3
MGTLPWLLAFFILGLQAWDTPTIVSRKEWGARPLACRALLTLPVAYIITDQLPGMQCQQQ
SVCSQMLRGLQSHSVYTIGWCDVAYNFLVGDDGRVYEGVGWNIQGLHTQGYNNISLGIAF
FGNKIGSSPSPAALSAAEGLISYAIQKGHLSPRYIQPLLLKEETCLDPQHPVMPRKVCPN
IIKRSAWEARETHCPKMNLPAKYVIIIHTAGTSCTVSTDCQTVVRNIQSFHMDTRNFCDI
GYHFLVGQDGGVYEGVGWHIQGSHTYGFNDIALGIAFIGYFVEKPPNAAALEAAQDLIQC
AVVEGYLTPNYLLMGHSDVVNILSPGQALYNIISTWPHFKH
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q96LB9 |
| UniProtKB/Swiss-Prot Entry Name
| PGRP3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AY035376 |
| GeneCard ID
| PGLYRP3 |
| GenAtlas ID
| PGLYRP3 |
| HGNC ID
| HGNC:30014 |
| References |
|---|
| General References
| Not Available |