| Identification |
|---|
| HMDB Protein ID
| CDBP04462 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase DZIP3 |
| Description
| Not Available |
| Synonyms
|
- DAZ-interacting protein 3
- RNA-binding ubiquitin ligase of 138 kDa
- hRUL138
|
| Gene Name
| DZIP3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
| protein binding |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Pyruvate Metabolism |    |  |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3q13.13 |
| SNPs
| DZIP3 |
| Gene Sequence
|
>3627 bp
ATGGATTCTCTACCAGATGAATTTTTTGTGAGGCATCCTGCTGTGGAGGATCAGAGGAAG
GAAGAAACTGAGAATAAGCTAGAAAAATCATCTGGTCAACTGAACAAACAGGAAAATGAC
ATACCTACTGATCTTGTCCCTGTTAACCTACTATTAGAAGTGAAGAAGTTATTAAATGCA
ATTAATACTCTACCAAAAGGTGTGGTTCCTCACATTAAGAAGTTCTTACAAGAAGATTTT
TCCTTCCAAACTATGCAGAGAGAAGTTGCAGCTAACAGCCAGAATGGTGAGGAAATTGTT
CCTGCTTTGACTTTACGTTTCTTGATTACACAGCTAGAAGCAGCACTTAGGAACATTCAA
GCTGGCAATTATACCGCACACCAGATTAATATTGGTTATTATTTGACATTACTGTTTTTA
TATGGAGTAGCACTCACTGAAAGAGGAAAGAAAGAGGATTATACAGAAGCTGAGAATAAA
TTTCTGGTGATGAAGATGATGATCCAAGAAAATGAAATTTGTGAAAACTTTATGTCTTTA
GTTTATTTTGGACGTGGTTTACTGCGATGTGCTCAAAAGAGATATAATGGAGGACTGCTA
GAATTTCATAAAAGCTTACAAGAAATTGGAGACAAAAATGACCATTGGTTTGACATAGAT
CCTACAGAAGATGAAGATTTACCTACAACTTTTAAAGATCTTCTTAATAATTTTATCAAG
ACAACTGAAAGCAATATAATGAAGCAGACGATTTGTAGTTACCTAGATTGTGAACGATCT
TGTGAAGCTGACATTTTGAAGAACACCAGTTATAAGGGATTTTTTCAGTTAATGTGCAGT
AAAAGTTGCTGTGTTTATTTCCATAAAATTTGCTGGAAAAAGTTCAAGAATTTAAAGTAT
CCAGGTGAAAATGATCAGAGTTTTAGTGGGAAAAAATGTTTGAAGGAAGGATGTACAGGT
GACATGGTAAGGATGCTGCAATGTGATGTACCTGGAATTGTTAAAATTTTGTTTGAAGTT
GTGAGAAAGGATGAATATATCACCATTGAAAATTTAGGAGCAAGTTATAGAAAGTTGATA
TCTCTGAAAATAACTGATACTGATATAAGACCGAAGATCAGTTTAAAATTTAATACAAAA
GATGAAATGCCTATCTTCAAGCTTGATTATAATTATTTCTATCATCTGCTTCATATAATT
ATTATTTCTGGTACTGACATTGTTCGACAAATATTTGATGAGGCTATGCCACCTCCTCTT
TTGAAAAAAGAGCTTCTTATACACAAGAATGTGCTGGAATCCTACTACAACCATCTTTGG
ACCAATCATCCTTTGGGTGGATCATGGCATCTGCTTTATCCTCCTAACAAGGAGTTACCG
CAATCCAAACAGTTTGACTTATGCCTCCTGTTAGCTCTTATAAAACATTTAAATGTGTTC
CCTGCACCCAAAAAAGGATGGAATATGGAACCGCCATCTTCTGACATCTCTAAATCTGCA
GACATCCTGAGACTGTGCAAATACAGGGATATCCTCCTTAGTGAGATTTTGATGAATGGT
CTCACTGAGTCACAGTTCAATTCAATTTGGAAAAAAGTTTCAGATATTCTTCTGCGCCTT
GGGATGATGCAAGAGGATATTGACAAAGTGAAGGAGAATCCCATTGAGAATATCTCCCTT
GATTACCATCAGCTATCTGTCTACCTAGGCATACCAGTACCAGAAATCATACAGAGGATG
TTATCCTGCTATCAACAAGGAATTGCTCTACAGTCAATAACAGGCAGTCAGCGTATTGAA
ATAGAAGAGTTACAGAATGAGGAAGAAGAACTAAGTCCACCTCTCATGGAGTACAATATA
AATGTGAAATCACACCCTGAGATACAGTTTGCAGAAATTAATAAAGATGGGACCTCAATA
CCCAGTGAATCTTCAACAGAATCTCTTAAAGATCTCCAGGAAGTTAAGAGTAAACAAAGG
AAAAAGAAGAAGACTAAGAATAAAAAGAATAAAGACTCAAAAGAAGACCAAGTCCCATAT
GTGGTAGAAAAGGAAGAGCAGTTGAGGAAAGAACAAGCAAATCCACACTCAGTCAGTAGA
CTTATAAAAGATGATGCAAGTGATGTTCAAGAGGATTCTGCAATGGAAGACAAGTTCTAT
AGCCTGGATGAATTGCATATTCTGGACATGATAGAGCAGGGCTCAGCTGGCAAAGTAACT
ACAGACTATGGAGAAACTGAAAAGGAAAGGCTTGCTCGTCAAAGGCAGCTTTATAAATTG
CACTATCAGTGTGAAGATTTCAAAAGACAGTTGAGAACAGTGACTTTTCGGTGGCAAGAA
AACCAAATGCAGATTAAAAAGAAAGACAAAATTATCGCATCTCTTAATCAACAAGTTGCT
TTTGGAATCAATAAGGTTTCCAAATTACAGCGTCAAATCCATGCTAAAGATAATGAAATC
AAGAACCTTAAAGAGCAACTTTCTATGAAAAGATCTCAGTGGGAAATGGAAAAACATAAT
CTGGAAAGCACAATGAAAACATACGTAAGCAAACTGAACGCAGAAACTAGCAGAGCTTTA
ACAGCCGAGGTGTATTTCTTACAGTGTCGTAGGGATTTTGGTTTGCTTCATCTAGAGCAG
ACTGAAAAGGAATGTCTCAATCAGCTTGCCAGGGTGACTCACATGGCAGCAAGCAACCTA
GAATCACTTCAATTAAAGGCTGCGGTAGACAGTTGGAATGCCATTGTGGCAGATGTTAGA
AACAAGATTGCATTCCTCAGGACACAGTACAATGAACAAATAAACAAAGTCAAGCAAGGA
TTTGCCTTGAGTACCTTGCCTCCAGTCCAGCTTCCTCCTCCACCACCCAGTCCTGAGATA
CTGATGCAGCAGTTCTTAGGAAGACCCCTTGTGAAAGAATCTTTCTTTAGACCCATACTT
ACTGTTCCTCAAATGCCTGCAGTTTGCCCGGGAGTCGTCTCTGCAACTGGCCAACCTAGA
GCCCCCCTGATGACTGGCATAGCCTGGGCTCTGCCAGCGCCTGTGGGAGACGCTGTGCCT
CCCAGTGCAGGTCTGCGGAGTGATCCCTCCATCATGAATTGGGAGAGAATTACAGACAGG
CTGAAAACTGCCTTTCCACAGCAAACCAGAAAGGAACTTACAGATTTCTTACGGAAATTG
AAGGATGCTTATGGAAAATCCTTGTCTGAACTGACATTTGATGAAATTGTTTGCAAGATT
TCCCAGTTTATTGACCCCAAAAAGTCTCAGAGTCAAGGAAAATCAGTGTCAAATGTTAAT
TGTGTTTCACCTAGTCATTCTCCATCACAGCCTGATGCTGCCCAGCCCCCAAAACCAGCC
TGGAGGCCACTCACTTCACAGGGTCCTGCCACATGGGAAGGAGCCAGTAATCCAGATGAG
GAAGAGGAAGAAGAAGAGCCTTGTGTGATCTGTCATGAGAATCTGTCTCCAGAAAATCTT
TCAGTTTTGCCTTGCGCTCACAAATTCCATGCTCAGTGCATTAGACCATGGTTGATGCAA
CAGGGGACATGTCCAACGTGCAGACTCCACGTTTTGCTACCAGAAGAATTCCCTGGTCAC
CCCAGCCGGCAGTTGCCCAAGATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1208 |
| Molecular Weight
| 138603.1 |
| Theoretical pI
| 6.87 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase DZIP3
MDSLPDEFFVRHPAVEDQRKEETENKLEKSSGQLNKQENDIPTDLVPVNLLLEVKKLLNA
INTLPKGVVPHIKKFLQEDFSFQTMQREVAANSQNGEEIVPALTLRFLITQLEAALRNIQ
AGNYTAHQINIGYYLTLLFLYGVALTERGKKEDYTEAENKFLVMKMMIQENEICENFMSL
VYFGRGLLRCAQKRYNGGLLEFHKSLQEIGDKNDHWFDIDPTEDEDLPTTFKDLLNNFIK
TTESNIMKQTICSYLDCERSCEADILKNTSYKGFFQLMCSKSCCVYFHKICWKKFKNLKY
PGENDQSFSGKKCLKEGCTGDMVRMLQCDVPGIVKILFEVVRKDEYITIENLGASYRKLI
SLKITDTDIRPKISLKFNTKDEMPIFKLDYNYFYHLLHIIIISGTDIVRQIFDEAMPPPL
LKKELLIHKNVLESYYNHLWTNHPLGGSWHLLYPPNKELPQSKQFDLCLLLALIKHLNVF
PAPKKGWNMEPPSSDISKSADILRLCKYRDILLSEILMNGLTESQFNSIWKKVSDILLRL
GMMQEDIDKVKENPIENISLDYHQLSVYLGIPVPEIIQRMLSCYQQGIALQSITGSQRIE
IEELQNEEEELSPPLMEYNINVKSHPEIQFAEINKDGTSIPSESSTESLKDLQEVKSKQR
KKKKTKNKKNKDSKEDQVPYVVEKEEQLRKEQANPHSVSRLIKDDASDVQEDSAMEDKFY
SLDELHILDMIEQGSAGKVTTDYGETEKERLARQRQLYKLHYQCEDFKRQLRTVTFRWQE
NQMQIKKKDKIIASLNQQVAFGINKVSKLQRQIHAKDNEIKNLKEQLSMKRSQWEMEKHN
LESTMKTYVSKLNAETSRALTAEVYFLQCRRDFGLLHLEQTEKECLNQLARVTHMAASNL
ESLQLKAAVDSWNAIVADVRNKIAFLRTQYNEQINKVKQGFALSTLPPVQLPPPPPSPEI
LMQQFLGRPLVKESFFRPILTVPQMPAVCPGVVSATGQPRAPLMTGIAWALPAPVGDAVP
PSAGLRSDPSIMNWERITDRLKTAFPQQTRKELTDFLRKLKDAYGKSLSELTFDEIVCKI
SQFIDPKKSQSQGKSVSNVNCVSPSHSPSQPDAAQPPKPAWRPLTSQGPATWEGASNPDE
EEEEEEPCVICHENLSPENLSVLPCAHKFHAQCIRPWLMQQGTCPTCRLHVLLPEEFPGH
PSRQLPKI
|
| External Links |
|---|
| GenBank ID Protein
| 7662244 |
| UniProtKB/Swiss-Prot ID
| Q86Y13 |
| UniProtKB/Swiss-Prot Entry Name
| DZIP3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_014648.3 |
| GeneCard ID
| DZIP3 |
| GenAtlas ID
| DZIP3 |
| HGNC ID
| HGNC:30938 |
| References |
|---|
| General References
| Not Available |