| Identification |
|---|
| HMDB Protein ID
| CDBP04460 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase MARCH9 |
| Description
| Not Available |
| Synonyms
|
- MARCH-IX
- Membrane-associated RING finger protein 9
- Membrane-associated RING-CH protein IX
- RING finger protein 179
|
| Gene Name
| MARCH9 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
|
| Cellular Location
|
- Golgi apparatus membrane
- Lysosome membrane
- Multi-pass membrane protein
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q14.1 |
| SNPs
| MARCH9 |
| Gene Sequence
|
>1041 bp
ATGCTCAAGTCTCGGCTCCGCATGTTTCTGAACGAGCTGAAGCTGCTGGTGCTGACAGGC
GGGGGGCGGCCCCGGGCCGAGCCGCAACCCCGGGGGGGCCGGGGAGGCGGCTGCGGCTGG
GCGCCCTTCGCTGGTTGCTCCACCCGGGACGGCGACGGCGACGAGGAGGAGTACTACGGG
TCGGAGCCGCGGGCCCGGGGCCTGGCCGGCGACAAGGAGCCGCGGGCCGGACCCCTGCCG
CCGCCCGCGCCGCCGCTGCCGCCCCCGGGCGCGCTGGACGCCCTGTCGCTCAGCAGTAGC
CTGGACAGCGGACTCCGAACCCCTCAGTGCCGGATCTGCTTCCAGGGCCCGGAGCAGGGG
GAGCTCTTAAGCCCCTGCCGCTGCGACGGCTCAGTGCGCTGCACGCATCAGCCCTGCCTC
ATCCGCTGGATCAGCGAGAGGGGCTCCTGGAGCTGTGAGCTCTGCTACTTCAAGTACCAG
GTCCTGGCGATCAGCACCAAGAACCCACTGCAGTGGCAGGCCATCTCCCTGACGGTCATC
GAGAAGGTCCAGATTGCTGCCATAGTTCTGGGCTCGCTCTTCCTGGTTGCCAGCATCTCC
TGGCTCATCTGGTCCTCACTCAGCCCTTCAGCCAAGTGGCAACGACAGGATCTGCTCTTT
CAGATCTGCTACGGCATGTATGGCTTCATGGATGTCGTCTGCATAGGCCTCATCATCCAT
GAAGGCTCCTCTGTCTACCGCATCTTCAAGCGCTGGCAGGCAGTGAACCAGCAGTGGAAG
GTCCTAAATTATGACAAGACCAAGGACATAGGAGGAGATGCAGGGGGAGGGACGGCAGGG
AAGTCAGGCCCCAGGAACTCACGGACGGGCCCCACCTCTGGGGCCACGAGCCGCCCCCCA
GCTGCCCAGCGCATGCGGACGCTCTTGCCTCAGCGCTGCGGTTATACAATCTTGCACCTC
CTTGGGCAGCTGCGGCCACCAGATGCCCGTTCCAGCTCCCATTCTGGCCGAGAGGTTGTC
ATGAGGGTCACTACAGTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 346 |
| Molecular Weight
| 37772.1 |
| Theoretical pI
| 9.35 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase MARCH9
MLKSRLRMFLNELKLLVLTGGGRPRAEPQPRGGRGGGCGWAPFAGCSTRDGDGDEEEYYG
SEPRARGLAGDKEPRAGPLPPPAPPLPPPGALDALSLSSSLDSGLRTPQCRICFQGPEQG
ELLSPCRCDGSVRCTHQPCLIRWISERGSWSCELCYFKYQVLAISTKNPLQWQAISLTVI
EKVQIAAIVLGSLFLVASISWLIWSSLSPSAKWQRQDLLFQICYGMYGFMDVVCIGLIIH
EGSSVYRIFKRWQAVNQQWKVLNYDKTKDIGGDAGGGTAGKSGPRNSRTGPTSGATSRPP
AAQRMRTLLPQRCGYTILHLLGQLRPPDARSSSHSGREVVMRVTTV
|
| External Links |
|---|
| GenBank ID Protein
| 40255016 |
| UniProtKB/Swiss-Prot ID
| Q86YJ5 |
| UniProtKB/Swiss-Prot Entry Name
| MARH9_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_138396.4 |
| GeneCard ID
| MARCH9 |
| GenAtlas ID
| MARCH9 |
| HGNC ID
| HGNC:25139 |
| References |
|---|
| General References
| Not Available |