| Identification |
|---|
| HMDB Protein ID
| CDBP04454 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase ZNRF1 |
| Description
| Not Available |
| Synonyms
|
- Nerve injury-induced gene 283 protein
- Zinc/RING finger protein 1
|
| Gene Name
| ZNRF1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to substrates. May play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin-protein ligase activity |
| GO Classification
|
| Function |
| zinc ion binding |
| protein binding |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
|
| Cellular Location
|
- Peripheral membrane protein
- Lysosome
- Cytoplasmic vesicle
- Membrane
- secretory vesicle
- Peripheral membrane protein (Potential)
- Endosome
- synaptic vesicle membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16q23.1 |
| SNPs
| ZNRF1 |
| Gene Sequence
|
>684 bp
ATGGGGGGCAAGCAGAGCACGGCGGCCCGCTCCCGGGGCCCCTTCCCGGGGGTCTCCACC
GATGACAGCGCCGTGCCGCCGCCGGGAGGGGCGCCCCATTTCGGGCACTACCGGACGGGC
GGCGGGGCCATGGGGCTGCGCAGCCGCTCGGTCAGCTCGGTGGCAGGCATGGGCATGGAC
CCCAGCACGGCCGGGGGGGTGCCCTTTGGCCTCTACACCCCCGCCTCCCGGGGCACCGGC
GACTCCGAGAGGGCGCCCGGCGGCGGAGGGTCTGCGTCCGACTCCACCTATGCCCATGGC
AATGGTTACCAGGAGACGGGCGGCGGTCACCATAGAGACGGGATGCTGTACCTGGGCTCC
CGAGCCTCGCTGGCGGATGCTCTACCTCTGCACATCGCACCCAGGTGGTTCAGCTCGCAT
AGTGGTTTCAAGTGCCCCATTTGCTCCAAGTCTGTGGCTTCTGACGAGATGGAAATGCAC
TTTATAATGTGTTTGAGCAAACCTCGCCTCTCCTACAACGATGATGTGCTGACTAAAGAC
GCGGGTGAGTGTGTGATCTGCCTGGAGGAGCTGCTGCAGGGGGACACGATAGCCAGGCTG
CCCTGCCTGTGCATCTATCACAAAAGCTGCATAGACTCGTGGTTTGAAGTGAACAGATCT
TGTCCGGAACACCCTGCGGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 227 |
| Molecular Weight
| 23782.4 |
| Theoretical pI
| 6.66 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase ZNRF1
MGGKQSTAARSRGPFPGVSTDDSAVPPPGGAPHFGHYRTGGGAMGLRSRSVSSVAGMGMD
PSTAGGVPFGLYTPASRGTGDSERAPGGGGSASDSTYAHGNGYQETGGGHHRDGMLYLGS
RASLADALPLHIAPRWFSSHSGFKCPICSKSVASDEMEMHFIMCLSKPRLSYNDDVLTKD
AGECVICLEELLQGDTIARLPCLCIYHKSCIDSWFEVNRSCPEHPAD
|
| External Links |
|---|
| GenBank ID Protein
| 14583079 |
| UniProtKB/Swiss-Prot ID
| Q8ND25 |
| UniProtKB/Swiss-Prot Entry Name
| ZNRF1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF378524 |
| GeneCard ID
| ZNRF1 |
| GenAtlas ID
| ZNRF1 |
| HGNC ID
| HGNC:18452 |
| References |
|---|
| General References
| Not Available |