| Identification |
|---|
| HMDB Protein ID
| CDBP04452 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase TRIM63 |
| Description
| Not Available |
| Synonyms
|
- Iris RING finger protein
- MuRF-1
- MuRF1
- Muscle-specific RING finger protein 1
- RING finger protein 28
- Striated muscle RING zinc finger protein
- Tripartite motif-containing protein 63
|
| Gene Name
| TRIM63 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric- associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
| protein binding |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p34-p33 |
| SNPs
| TRIM63 |
| Gene Sequence
|
>1062 bp
ATGGATTATAAGTCGAGCCTGATCCAGGATGGGAATCCCATGGAGAACTTGGAGAAGCAG
CTGATCTGCCCTATCTGCCTGGAGATGTTTACCAAGCCAGTGGTCATCTTGCCGTGCCAG
CACAACCTGTGCCGGAAGTGTGCCAATGACATCTTCCAGGCTGCAAATCCCTACTGGACC
AGCCGGGGCAGCTCAGTGTCCATGTCTGGAGGCCGTTTCCGCTGCCCCACCTGCCGCCAC
GAGGTGATCATGGATCGTCACGGAGTGTACGGCCTGCAGAGGAACCTGCTGGTGGAGAAC
ATCATCGACATCTACAAACAGGAGTGCTCCAGTCGGCCGCTGCAGAAGGGCAGTCACCCC
ATGTGCAAGGAGCACGAAGATGAGAAAATCAACATCTACTGTCTCACGTGTGAGGTGCCC
ACCTGCTCCATGTGCAAGGTGTTTGGGATCCACAAGGCCTGCGAGGTGGCCCCATTGCAG
AGTGTCTTCCAGGGACAAAAGACTGAACTGAATAACTGTATCTCCATGCTGGTGGCGGGG
AATGACCGTGTGCAGACCATCATCACTCAGCTGGAGGATTCCCGTCGAGTGACCAAGGAG
AACAGTCACCAGGTAAAGGAAGAGCTGAGCCAGAAGTTTGACACGTTGTATGCCATCCTG
GATGAGAAGAAAAGTGAGTTGCTGCAGCGGATCACGCAGGAGCAGGAGAAAAAGCTTAGC
TTCATCGAGGCCCTCATCCAGCAGTACCAGGAGCAGCTGGACAAGTCCACAAAGCTGGTG
GAAACTGCCATCCAGTCCCTGGACGAGCCTGGGGGAGCCACCTTCCTCTTGACTGCCAAG
CAACTCATCAAAAGCATTGTGGAAGCTTCCAAGGGCTGCCAGCTGGGGAAGACAGAGCAG
GGCTTTGAGAACATGGACTTCTTTACTTTGGATTTAGAGCACATAGCAGACGCCCTGAGA
GCCATTGACTTTGGGACAGATGAGGAAGAGGAAGAATTCATTGAAGAAGAAGATCAGGAA
GAGGAAGAGTCCACAGAAGGGAAGGAAGAAGGACACCAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 353 |
| Molecular Weight
| 40247.3 |
| Theoretical pI
| 4.57 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase TRIM63
MDYKSSLIQDGNPMENLEKQLICPICLEMFTKPVVILPCQHNLCRKCANDIFQAANPYWT
SRGSSVSMSGGRFRCPTCRHEVIMDRHGVYGLQRNLLVENIIDIYKQECSSRPLQKGSHP
MCKEHEDEKINIYCLTCEVPTCSMCKVFGIHKACEVAPLQSVFQGQKTELNNCISMLVAG
NDRVQTIITQLEDSRRVTKENSHQVKEELSQKFDTLYAILDEKKSELLQRITQEQEKKLS
FIEALIQQYQEQLDKSTKLVETAIQSLDEPGGATFLLTAKQLIKSIVEASKGCQLGKTEQ
GFENMDFFTLDLEHIADALRAIDFGTDEEEEEFIEEEDQEEEESTEGKEEGHQ
|
| External Links |
|---|
| GenBank ID Protein
| 13785924 |
| UniProtKB/Swiss-Prot ID
| Q969Q1 |
| UniProtKB/Swiss-Prot Entry Name
| TRI63_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF353673 |
| GeneCard ID
| TRIM63 |
| GenAtlas ID
| TRIM63 |
| HGNC ID
| HGNC:16007 |
| References |
|---|
| General References
| Not Available |