| Identification |
|---|
| HMDB Protein ID
| CDBP04444 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ubiquitin-conjugating enzyme E2 Z |
| Description
| Not Available |
| Synonyms
|
- Uba6-specific E2 conjugating enzyme 1
- Ubiquitin carrier protein Z
- Ubiquitin-protein ligase Z
- Use1
|
| Gene Name
| UBE2Z |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acid-amino acid ligase activity |
| Specific Function
| Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.
|
| GO Classification
|
| Biological Process |
| apoptotic process |
| Cellular Component |
| cytoplasm |
| nucleus |
| Function |
| catalytic activity |
| small conjugating protein ligase activity |
| ligase activity |
| ligase activity, forming carbon-nitrogen bonds |
| acid-amino acid ligase activity |
| Molecular Function |
| ubiquitin-protein ligase activity |
| ATP binding |
| Process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| post-translational protein modification |
| macromolecule modification |
| protein modification process |
| metabolic process |
| regulation of protein metabolic process |
| macromolecule metabolic process |
| biological regulation |
| regulation of biological process |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein ubiquitination | Not Available | Not Available | | Ubiquitin mediated proteolysis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17q21.32 |
| SNPs
| UBE2Z |
| Gene Sequence
|
>1065 bp
ATGGCGGAGAGTCCGACTGAGGAGGCGGCAACGGCGGGCGCCGGGGCGGCGGGCCCCGGG
GCGAGCAGCGTTGCTGGTGTTGTTGGCGTTAGCGGCAGCGGCGGCGGGTTCGGGCCGCCT
TTCCTGCCGGATGTGTGGGCGGCGGCGGCGGCAGCGGGCGGGGCCGGGGGCCCGGGGAGC
GGCCTGGCTCCGCTGCCCGGGCTCCCGCCCTCAGCCGCTGCCCACGGGGCCGCGCTGCTT
AGCCACTGGGACCCCACGCTCAGCTCCGACTGGGACGGCGAGCGCACCGCGCCGCAGTGT
CTACTCCGGATCAAGCGGGATATCATGTCCATTTATAAGGAGCCTCCTCCAGGAATGTTC
GTTGTACCTGATACTGTTGACATGACTAAGATTCATGCATTGATCACAGGCCCATTTGAC
ACTCCTTATGAAGGGGGTTTCTTCCTGTTCGTGTTTCGGTGTCCGCCCGACTATCCCATC
CACCCACCTCGGGTCAAACTGATGACAACGGGCAATAACACAGTGAGGTTTAACCCCAAC
TTCTACCGCAATGGGAAAGTCTGCTTGAGTATTCTAGGTACATGGACTGGACCTGCCTGG
AGCCCAGCCCAGAGCATCTCCTCAGTGCTCATCTCTATCCAGTCCCTGATGACTGAGAAC
CCCTATCACAATGAGCCCGGCTTTGAACAGGAGAGACATCCAGGAGACAGCAAAAACTAT
AATGAATGTATCCGGCACGAGACCATCAGAGTTGCAGTCTGTGACATGATGGAAGGAAAG
TGTCCCTGTCCTGAACCCCTACGAGGGGTGATGGAGAAGTCCTTTCTGGAGTATTACGAC
TTCTACGAGGTGGCCTGCAAAGATCGCCTGCACCTTCAAGGCCAAACTATGCAGGACCCT
TTTGGAGAGAAGCGGGGCCACTTTGACTACCAGTCCCTCTTGATGCGCCTGGGACTGATA
CGTCAGAAAGTGCTGGAGAGGCTCCATAATGAGAATGCAGAAATGGACTCTGATAGCAGT
TCATCTGGGACAGAGACAGACCTTCATGGGAGCCTGAGGGTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 354 |
| Molecular Weight
| 38209.875 |
| Theoretical pI
| 5.617 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ubiquitin-conjugating enzyme E2 Z
MAESPTEEAATAGAGAAGPGASSVAGVVGVSGSGGGFGPPFLPDVWAAAAAAGGAGGPGS
GLAPLPGLPPSAAAHGAALLSHWDPTLSSDWDGERTAPQCLLRIKRDIMSIYKEPPPGMF
VVPDTVDMTKIHALITGPFDTPYEGGFFLFVFRCPPDYPIHPPRVKLMTTGNNTVRFNPN
FYRNGKVCLSILGTWTGPAWSPAQSISSVLISIQSLMTENPYHNEPGFEQERHPGDSKNY
NECIRHETIRVAVCDMMEGKCPCPEPLRGVMEKSFLEYYDFYEVACKDRLHLQGQTMQDP
FGEKRGHFDYQSLLMRLGLIRQKVLERLHNENAEMDSDSSSSGTETDLHGSLRV
|
| External Links |
|---|
| GenBank ID Protein
| 150417999 |
| UniProtKB/Swiss-Prot ID
| Q9H832 |
| UniProtKB/Swiss-Prot Entry Name
| UBE2Z_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_023079.4 |
| GeneCard ID
| UBE2Z |
| GenAtlas ID
| UBE2Z |
| HGNC ID
| HGNC:25847 |
| References |
|---|
| General References
| Not Available |