| Identification |
|---|
| HMDB Protein ID
| CDBP04436 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase RNF5 |
| Description
| Not Available |
| Synonyms
|
- HsRma1
- Protein G16
- RING finger protein 5
- Ram1 homolog
|
| Gene Name
| RNF5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses |
| GO Classification
|
| Function |
| transition metal ion binding |
| zinc ion binding |
| protein binding |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
|
| Cellular Location
|
- Membrane
- Endoplasmic reticulum membrane
- Mitochondrion membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6p21.3 |
| SNPs
| RNF5 |
| Gene Sequence
|
>543 bp
ATGGCAGCAGCGGAGGAGGAGGACGGGGGCCCCGAAGGGCCAAATCGCGAGCGGGGCGGG
GCGGGCGCGACCTTCGAATGTAATATATGTTTGGAGACTGCTCGGGAAGCTGTGGTCAGT
GTGTGTGGCCACCTGTACTGTTGGCCATGTCTTCATCAGTGGCTGGAGACACGGCCAGAA
CGGCAAGAGTGTCCAGTATGTAAAGCTGGGATCAGCAGAGAGAAGGTTGTCCCGCTTTAT
GGGCGAGGGAGCCAGAAGCCCCAGGATCCCAGATTAAAAACTCCACCCCGCCCCCAGGGC
CAGAGACCAGCTCCGGAGAGCAGAGGGGGATTCCAGCCATTTGGTGATACCGGGGGCTTC
CACTTCTCATTTGGTGTTGGTGCTTTTCCCTTTGGCTTTTTCACCACCGTCTTCAATGCC
CATGAGCCTTTCCGCCGGGGTACAGGTGTGGATCTGGGACAGGGTCACCCAGCCTCCAGC
TGGCAGGATTCCCTCTTCCTGTTTCTCGCCATCTTCTTCTTTTTTTGGCTGCTCAGTATT
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 180 |
| Molecular Weight
| 19881.3 |
| Theoretical pI
| 6.65 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase RNF5
MAAAEEEDGGPEGPNRERGGAGATFECNICLETAREAVVSVCGHLYCWPCLHQWLETRPE
RQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQRPAPESRGGFQPFGDTGGF
HFSFGVGAFPFGFFTTVFNAHEPFRRGTGVDLGQGHPASSWQDSLFLFLAIFFFFWLLSI
|
| External Links |
|---|
| GenBank ID Protein
| 13366064 |
| UniProtKB/Swiss-Prot ID
| Q99942 |
| UniProtKB/Swiss-Prot Entry Name
| RNF5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB056869 |
| GeneCard ID
| RNF5 |
| GenAtlas ID
| RNF5 |
| HGNC ID
| HGNC:10068 |
| References |
|---|
| General References
| Not Available |