| Identification |
|---|
| HMDB Protein ID
| CDBP04434 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase MARCH4 |
| Description
| Not Available |
| Synonyms
|
- MARCH-IV
- Membrane-associated RING finger protein 4
- Membrane-associated RING-CH protein IV
- RING finger protein 174
|
| Gene Name
| MARCH4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates |
| GO Classification
|
| Function |
| binding |
| transition metal ion binding |
| zinc ion binding |
| ion binding |
| cation binding |
| metal ion binding |
|
| Cellular Location
|
- Golgi apparatus membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q35 |
| SNPs
| MARCH4 |
| Gene Sequence
|
>1233 bp
ATGCTGATGCCCCTGTGTGGGCTGCTCTGGTGGTGGTGGTGCTGCTGCTCCGGCTGGTAC
TGCTATGGATTGTGTGCCCCAGCCCCCCAGATGTTGCGCCACCAGGGTCTCCTCAAGTGC
CGCTGCCGCATGCTCTTCAATGACCTGAAGGTTTTCTTACTGCGGCGCCCTCCTCAAGCG
CCCCTGCCCATGCACGGCGACCCCCAGCCCCCCGGTTTGGCGGCCAACAACACCCTTCCG
GCTCTGGGCGCCGGGGGGTGGGCAGGCTGGAGGGGCCCCCGAGAAGTGGTGGGCAGGGAG
CCCCCTCCTGTGCCACCTCCACCCCCCTTGCCACCTTCTTCTGTGGAAGATGACTGGGGT
GGCCCAGCCACAGAGCCACCTGCCTCGCTGCTCAGCAGTGCCTCCTCAGATGACTTCTGT
AAGGAGAAGACCGAGGATCGCTACTCACTGGGCAGCAGCTTGGACAGTGGTATGAGGACC
CCACTCTGCCGCATCTGCTTCCAGGGGCCAGAACAGGGGGAGCTGCTGAGCCCATGCCGC
TGTGATGGCTCGGTCAAGTGCACACACCAGCCTTGCCTCATCAAGTGGATCAGCGAGCGG
GGCTGCTGGAGCTGCGAGCTGTGCTACTACAAGTACCACGTCATCGCCATAAGCACAAAA
AATCCTCTGCAGTGGCAGGCCATCTCTCTGACGGTCATTGAGAAGGTTCAGGTTGCAGCC
GCCATCCTGGGCTCCCTCTTCCTCATCGCCAGTATTTCTTGGCTCATCTGGTCAACTTTC
AGCCCCTCGGCAAGATGGCAGCGCCAAGACCTTCTCTTCCAGATCTGCTACGGGATGTAT
GGCTTCATGGACGTGGTGTGCATAGGTCTCATCATCCATGAAGGACCCTCGGTGTACCGC
ATCTTTAAACGGTGGCAGGCTGTCAACCAGCAGTGGAAAGTGCTGAACTATGACAAGACA
AAAGACCTGGAGGATCAAAAGGCAGGAGGCAGGACCAACCCCCGGACCTCCTCATCCACC
CAGGCCAATATCCCCTCCTCGGAAGAGGAGACCGCAGGCACCCCTGCCCCTGAGCAGGGC
CCTGCCCAGGCTGCCGGCCACCCCTCAGGCCCTCTGTCCCATCACCACTGTGCTTATACC
ATCCTGCACATCCTGAGTCACTTGAGACCTCATGAACAGCGAAGTCCCCCAGGCAGCAGC
CGAGAGCTGGTCATGAGAGTCACGACAGTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 410 |
| Molecular Weight
| 45528.0 |
| Theoretical pI
| 7.9 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase MARCH4
MLMPLCGLLWWWWCCCSGWYCYGLCAPAPQMLRHQGLLKCRCRMLFNDLKVFLLRRPPQA
PLPMHGDPQPPGLAANNTLPALGAGGWAGWRGPREVVGREPPPVPPPPPLPPSSVEDDWG
GPATEPPASLLSSASSDDFCKEKTEDRYSLGSSLDSGMRTPLCRICFQGPEQGELLSPCR
CDGSVKCTHQPCLIKWISERGCWSCELCYYKYHVIAISTKNPLQWQAISLTVIEKVQVAA
AILGSLFLIASISWLIWSTFSPSARWQRQDLLFQICYGMYGFMDVVCIGLIIHEGPSVYR
IFKRWQAVNQQWKVLNYDKTKDLEDQKAGGRTNPRTSSSTQANIPSSEEETAGTPAPEQG
PAQAAGHPSGPLSHHHCAYTILHILSHLRPHEQRSPPGSSRELVMRVTTV
|
| External Links |
|---|
| GenBank ID Protein
| 57977325 |
| UniProtKB/Swiss-Prot ID
| Q9P2E8 |
| UniProtKB/Swiss-Prot Entry Name
| MARH4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_020814.2 |
| GeneCard ID
| MARCH4 |
| GenAtlas ID
| MARCH4 |
| HGNC ID
| HGNC:29269 |
| References |
|---|
| General References
| Not Available |