| Identification |
|---|
| HMDB Protein ID
| CDBP04418 |
| Secondary Accession Numbers
| Not Available |
| Name
| CCR4-NOT transcription complex subunit 4 |
| Description
| Not Available |
| Synonyms
|
- CCR4-associated factor 4
- E3 ubiquitin-protein ligase CNOT4
- Potential transcriptional repressor NOT4Hp
|
| Gene Name
| CNOT4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleotide binding |
| Specific Function
| Has E3 ubiquitin ligase activity. The CCR4-NOT complex functions as general transcription regulation complex |
| GO Classification
|
| Function |
| binding |
| nucleotide binding |
| transition metal ion binding |
| zinc ion binding |
| protein binding |
| nucleic acid binding |
| ion binding |
| cation binding |
| metal ion binding |
|
| Cellular Location
|
- Cytoplasm (Probable)
- Nucleus (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:7 |
| Locus
| 7q22-qter |
| SNPs
| CNOT4 |
| Gene Sequence
|
>1728 bp
ATGTCTCGCAGTCCTGATGCGAAGGAAGACCCTGTGGAGTGCCCTCTTTGCATGGAGCCC
TTGGAGATAGATGATATCAACTTTTTCCCTTGCACCTGTGGCTACCAGATTTGCCGATTT
TGTTGGCATCGAATTCGCACTGATGAAAATGGGCTTTGTCCTGCATGTAGAAAGCCATAT
CCAGAAGACCCAGCAGTTTATAAACCACTCTCCCAGGAAGAGCTGCAAAGGATAAAGAAT
GAGAAAAAACAGAAACAAAATGAGAGAAAACAGAAAATATCAGAAAATCGCAAACATTTG
GCTAGTGTACGTGTCGTACAAAAAAACCTCGTCTTTGTTGTAGGTTTATCTCAGCGCCTA
GCAGACCCAGAGGTTTTAAAACGACCAGAATATTTTGGGAAGTTTGGTAAAATACATAAA
GTTGTCATCAATAATAGCACATCATATGCAGGCTCACAGGGTCCAAGTGCCAGTGCTTAT
GTAACCTATATCCGGTCAGAAGACGCTCTCAGAGCCATACAGTGTGTCAACAATGTGGTA
GTAGATGGCAGAACACTTAAGGCATCTCTAGGTACAACAAAATACTGCAGTTACTTCTTA
AAGAATATGCAGTGTCCAAAACCTGACTGCATGTATCTTCATGAATTGGGGGATGAGGCG
GCCAGCTTCACAAAAGAGGAAATGCAGGCGGGTAAACACCAAGAATATGAACAGAAGCTA
CTTCAAGAATTATATAAATTAAATCCCAATTTTCTTCAGCTATCTACGGGTTCAGTTGAT
AAAAATAAGAACAAAGTGACACCACTGCAGAGGTACGATACCCCCATTGACAAACCTTCA
GATTCTCTCAGTATAGGGAACGGTGATAATTCCCAGCAGATATCTAACAGTGATACGCCT
TCACCACCACCTGGTTTGTCAAAATCCAATCCAGTCATCCCCATCAGTTCATCCAATCAC
AGTGCACGGTCCCCTTTTGAAGGGGCAGTAACAGAGTCACAGTCGTTATTCTCAGACAAT
TTTCGCCATCCCAACCCTATCCCAAGTGGGCTTCCTCCTTTCCCCAGCTCCCCACAGACA
TCCAGTGACTGGCCTACAGCACCAGAACCACAGAGCCTCTTCACATCAGAAACAATCCCA
GTATCATCCTCTACAGACTGGCAAGCAGCTTTTGGCTTTGGTTCTTCTAAACAACCAGAG
GATGACTTGGGTTTTGATCCCTTCGATGTCACTCGAAAAGCCTTAGCAGACCTGATTGAG
AAGGAACTGTCCGTTCAAGACCAACCTTCCCTTTCGCCCACATCTCTTCAGAACTCCTCT
TCACACACTACAACCGCCAAAGGTCCAGGCTCTGGATTCCTGCATCCTGCTGCAGCTACA
AATGCCAATTCTCTCAATAGTACCTTTTCAGTCTTGCCCCAGAGGTTCCCTCAATTTCAG
CAGCACCGAGCGGTTTATAATTCATTCAGTTTTCCAGGCCAGGCAGCCCGCTATCCTTGG
ATGGCCTTTCCACGCAATAGCATCATGCACTTGAACCACACAGCAAACCCCACCTCAAAT
AGTAATTTCTTGGACTTGAATCTCCCGCCACAGCACAACACAGGTCTGGGAGGGATCCCT
GTAGCAGGGGAAGAAGAGGTGAAGGTTTCGACCATGCCACTGTCAACCTCTTCCCATTCA
TTACAACAAGGACAGCAGCCTACAAGTCTCCACACTACTGTGGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 575 |
| Molecular Weight
| 63509.5 |
| Theoretical pI
| 7.04 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>CCR4-NOT transcription complex subunit 4
MSRSPDAKEDPVECPLCMEPLEIDDINFFPCTCGYQICRFCWHRIRTDENGLCPACRKPY
PEDPAVYKPLSQEELQRIKNEKKQKQNERKQKISENRKHLASVRVVQKNLVFVVGLSQRL
ADPEVLKRPEYFGKFGKIHKVVINNSTSYAGSQGPSASAYVTYIRSEDALRAIQCVNNVV
VDGRTLKASLGTTKYCSYFLKNMQCPKPDCMYLHELGDEAASFTKEEMQAGKHQEYEQKL
LQELYKLNPNFLQLSTGSVDKNKNKVTPLQRYDTPIDKPSDSLSIGNGDNSQQISNSDTP
SPPPGLSKSNPVIPISSSNHSARSPFEGAVTESQSLFSDNFRHPNPIPSGLPPFPSSPQT
SSDWPTAPEPQSLFTSETIPVSSSTDWQAAFGFGSSKQPEDDLGFDPFDVTRKALADLIE
KELSVQDQPSLSPTSLQNSSSHTTTAKGPGSGFLHPAAATNANSLNSTFSVLPQRFPQFQ
QHRAVYNSFSFPGQAARYPWMAFPRNSIMHLNHTANPTSNSNFLDLNLPPQHNTGLGGIP
VAGEEEVKVSTMPLSTSSHSLQQGQQPTSLHTTVA
|
| External Links |
|---|
| GenBank ID Protein
| 300069013 |
| UniProtKB/Swiss-Prot ID
| O95628 |
| UniProtKB/Swiss-Prot Entry Name
| CNOT4_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_001190848.1 |
| GeneCard ID
| CNOT4 |
| GenAtlas ID
| CNOT4 |
| HGNC ID
| HGNC:7880 |
| References |
|---|
| General References
| Not Available |