| Identification |
|---|
| HMDB Protein ID
| CDBP04408 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase UBR2 |
| Description
| Not Available |
| Synonyms
|
- N-recognin-2
- Ubiquitin-protein ligase E3-alpha-2
- Ubiquitin-protein ligase E3-alpha-II
|
| Gene Name
| UBR2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein catabolic process |
| Specific Function
| E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth |
| GO Classification
|
| Function |
| acid-amino acid ligase activity |
| ubiquitin-protein ligase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| small conjugating protein ligase activity |
| transition metal ion binding |
| zinc ion binding |
| ligase activity |
| protein binding |
| ligase activity, forming carbon-nitrogen bonds |
| Process |
| metabolic process |
| catabolic process |
| macromolecule catabolic process |
| protein catabolic process |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6p21.1 |
| SNPs
| UBR2 |
| Gene Sequence
|
>5268 bp
ATGGCGTCGGAGCTAGAGCCAGAGGTGCAGGCCATCGACCGGAGCTTGCTGGAATGTTCG
GCCGAGGAGATTGCGGGGAAATGGCTGCAAGCAACTGACCTCACTAGAGAAGTGTACCAG
CATTTAGCCCACTATGTACCCAAAATCTACTGCAGGGGTCCCAACCCTTTTCCACAGAAA
GAAGACATGCTGGCACAGCATGTTTTGTTGGGACCAATGGAATGGTACCTTTGTGGTGAA
GATCCTGCATTTGGATTTCCAAAACTTGAGCAAGCAAACAAACCTTCTCATCTTTGTGGT
CGTGTTTTTAAAGTAGGAGAGCCTACATATTCTTGCAGAGACTGTGCAGTTGATCCAACT
TGTGTTTTGTGCATGGAGTGCTTTTTGGGAAGTATTCACAGAGATCATCGATATAGGATG
ACAACATCAGGAGGTGGAGGTTTCTGTGACTGTGGTGATACTGAAGCCTGGAAAGAGGGT
CCTTACTGTCAAAAACATGAACTTAACACCTCTGAAATTGAGGAAGAAGAGGATCCTCTT
GTTCATTTATCAGAAGATGTGATAGCAAGAACTTATAACATTTTTGCTATTACGTTTCGG
TATGCAGTAGAAATATTAACCTGGGAAAAAGAAAGTGAATTGCCAGCAGATTTAGAGATG
GTAGAGAAGAGTGACACCTACTATTGCATGCTGTTTAATGATGAGGTTCACACCTATGAA
CAAGTTATTTATACTCTTCAGAAAGCTGTTAACTGTACACAAAAAGAAGCTATTGGTTTT
GCAACTACAGTAGATCGAGATGGGCGTAGGTCTGTTCGATATGGAGATTTTCAGTATTGT
GAGCAAGCAAAATCAGTAATTGTGAGAAATACCAGTAGACAGACAAAGCCACTCAAAGTT
CAAGTTATGCATTCGTCTATTGTCGCACATCAGAATTTTGGTTTGAAACTTTTGTCTTGG
CTGGGAAGTATTATTGGATATTCAGATGGCCTTCGCCGGATTTTATGTCAAGTTGGTTTA
CAAGAAGGGCCAGATGGTGAAAACTCTTCTCTAGTGGACAGACTGATGCTTAGTGATTCC
AAATTATGGAAAGGTGCTAGGAGTGTATATCATCAGTTGTTCATGAGCAGTCTGCTTATG
GATTTGAAATACAAGAAACTATTTGCTGTTCGATTTGCAAAAAATTACCAGCAGTTGCAG
AGAGATTTTATGGAGGATGATCACGAGCGAGCAGTGTCGGTGACTGCTCTATCTGTCCAG
TTCTTCACCGCACCTACTCTGGCTCGAATGCTCATCACAGAAGAAAACTTAATGAGCATT
ATCATTAAGACTTTTATGGATCATTTGAGACATCGAGATGCCCAGGGCAGATTTCAGTTT
GAACGATACACTGCTTTACAAGCCTTCAAATTTAGGAGAGTACAGAGCCTTATTTTAGAT
CTCAAGTATGTGTTAATTAGCAAACCAACTGAATGGTCAGATGAGCTGAGGCAGAAGTTC
CTAGAAGGGTTTGATGCCTTTTTGGAATTACTAAAATGTATGCAGGGAATGGATCCAATT
ACACGTCAAGTAGGACAACATATTGAAATGGAACCAGAGTGGGAAGCAGCCTTCACACTA
CAAATGAAATTAACACATGTCATTTCAATGATGCAGGACTGGTGTGCTTCAGATGAAAAA
GTGTTAATCGAAGCTTACAAGAAATGTCTCGCTGTACTGATGCAGTGTCATGGTGGTTAT
ACTGATGGTGAACAGCCAATCACACTAAGCATTTGTGGACATTCAGTGGAAACTATCAGA
TACTGTGTTTCCCAAGAAAAAGTTAGCATTCACCTCCCAGTTTCTCGCTTACTTGCAGGT
TTACATGTATTATTAAGCAAAAGTGAAGTGGCATATAAATTTCCAGAGCTCCTACCTCTA
AGTGAACTTAGCCCACCCATGTTGATAGAACACCCTCTTAGATGTCTTGTTCTGTGTGCC
CAAGTACATGCCGGAATGTGGAGAAGAAATGGGTTCTCTCTAGTAAACCAGATTTATTAC
TACCATAATGTGAAATGCAGACGTGAGATGTTTGACAAGGATGTAGTAATGCTTCAGACA
GGTGTCTCCATGATGGATCCAAATCATTTCCTGATGATCATGCTCAGCCGCTTTGAACTT
TATCAGATTTTCAGTACTCCAGACTATGGAAAAAGATTTAGTTCTGAGATTACCCATAAG
GATGTTGTTCAGCAGAACAATACTCTAATAGAAGAAATGCTATACCTCATTATAATGCTT
GTTGGAGAGAGATTTAGTCCTGGAGTTGGACAGGTAAATGCTACAGATGAAATCAAGCGA
GAGATTATCCATCAGTTGAGTATCAAGCCTATGGCTCATAGTGAATTGGTAAAGTCTTTA
CCTGAAGATGAGAACAAGGAGACTGGCATGGAGAGTGTAATCGAAGCAGTTGCCCATTTC
AAGAAACCTGGATTAACAGGACGAGGCATGTATGAACTGAAACCAGAATGTGCCAAAGAG
TTCAACTTGTATTTCTATCACTTTTCAAGGGCAGAACAGTCCAAGGCAGAAGAAGCGCAA
CGGAAATTGAAAAGACAAAATAGAGAAGATACAGCACTCCCACCTCCGGTGTTGCCTCCA
TTCTGCCCTCTGTTTGCAAGCCTGGTTAACATTTTGCAGTCAGATGTCATGTTGTGCATC
ATGGGAACAATTCTGCAATGGGCTGTGGAACATAATGGATATGCCTGGTCAGAGTCCATG
CTGCAAAGGGTGTTACATTTAATTGGCATGGCACTACAAGAAGAAAAACAACATTTAGAG
AATGTCACGGAAGAGCATGTAGTAACATTTACCTTCACTCAGAAGATATCAAAACCTGGT
GAAGCGCCAAAAAATTCTCCTAGCATACTAGCTATGCTGGAAACACTACAAAATGCTCCC
TACCTAGAAGTCCACAAAGACATGATTCGGTGGATATTGAAGACTTTTAATGCTGTTAAA
AAGATGAGGGAGAGTTCACCTACCAGTCCCGTGGCAGAGACAGAAGGAACCATAATGGAA
GAGAGTTCAAGGGACAAAGACAAAGCTGAGAGGAAGAGAAAAGCAGAGATTGCCAGACTG
CGCAGAGAAAAGATCATGGCTCAGATGTCTGAAATGCAGCGGCATTTTATTGATGAAAAC
AAAGAACTCTTTCAGCAGACATTAGAACTGGATGCCTCAACCTCTGCTGTTCTTGATCAT
AGCCCTGTGGCTTCAGATATGACACTTACAGCACTGGGCCCCGCACAAACTCAGGTTCCT
GAACAAAGACAATTCGTTACATGTATATTGTGTCAAGAGGAGCAAGAAGTTAAAGTGGAA
AGCAGGGCAATGGTCTTGGCAGCATTTGTTCAGAGATCAACTGTATTATCAAAAAACAGA
AGTAAATTTATTCAAGATCCAGAAAAATATGATCCATTATTCATGCACCCTGATCTGTCT
TGTGGAACACACACTAGTAGCTGTGGGCACATTATGCATGCCCATTGTTGGCAAAGGTAT
TTTGATTCCGTTCAAGCTAAAGAACAGCGAAGGCAACAGAGATTACGCTTACATACGAGC
TATGATGTAGAAAACGGAGAATTCCTTTGCCCCCTTTGTGAATGCTTGAGTAATACTGTT
ATTCCTCTGCTGCTTCCTCCAAGAAATATTTTTAACAACAGGTTAAATTTTTCAGACCAA
CCAAATCTGACTCAGTGGATTAGAACAATATCTCAGCAAATAAAAGCATTACAGTTTCTT
AGGAAAGAAGAAAGTACTCCTAATAATGCCTCTACAAAGAATTCAGAAAATGTGGATGAA
TTACAGCTCCCTGAAGGGTTCAGGCCTGATTTTCGTCCTAAGATCCCTTATTCTGAGAGC
ATAAAAGAAATGCTAACGACATTTGGAACTGCTACCTACAAGGTGGGACTAAAGGTTCAT
CCCAATGAAGAGGATCCTCGTGTTCCCATAATGTGTTGGGGTAGCTGCGCGTACACCATC
CAAAGCATAGAAAGAATTTTGAGTGATGAAGATAAACCATTGTTTGGTCCTTTACCTTGC
AGACTGGATGACTGTCTTAGGTCATTGACGAGATTTGCCGCAGCACACTGGACAGTGGCA
TCAGTTTCAGTGGTGCAAGGACATTTTTGTAAACTTTTTGCATCACTGGTGCCTAATGAC
AGCCATGAGGAACTTCCATGCATATTAGATATTGACATGTTTCATTTATTGGTGGGCTTG
GTGCTTGCATTTCCTGCGTTGCAGTGTCAGGATTTTTCAGGGATCAGCCTTGGCACTGGA
GACCTTCACATTTTCCATCTGGTTACTATGGCACACATCATACAGATCTTACTTACCTCA
TGTACAGAAGAGAATGGCATGGATCAAGAAAATCCCCCTTGTGAAGAAGAATCAGCAGTT
CTTGCTTTGTATAAAACACTTCACCAGTATACGGGAAGTGCCTTGAAAGAAATACCATCC
GGCTGGCATCTGTGGAGGAGTGTCAGAGCTGGAATCATGCCTTTCCTGAAGTGTTCTGCT
TTATTTTTTCATTACTTAAATGGAGTTCCTTCCCCACCCGACATTCAAGTTCCTGGAACA
AGCCATTTTGAACATTTATGTAGCTATCTTTCCCTACCAAACAACCTCATTTGCCTTTTT
CAAGAAAATAGTGAGATAATGAATTCACTGATTGAAAGTTGGTGCCGTAACAGTGAAGTT
AAAAGATATCTAGAAGGTGAAAGAGATGCTATAAGATATCCAAGAGAATCTAACAAATTA
ATAAACCTTCCAGAGGATTACAGCAGCCTCATTAATCAAGCATCCAATTTCTCGTGCCCG
AAATCAGGTGGTGATAAGAGCAGAGCCCCAACTCTGTGCCTTGTGTGCGGATCTCTGCTG
TGCTCCCAGAGTTACTGCTGCCAGACTGAACTGGAAGGGGAGGATGTAGGAGCCTGCACA
GCTCACACCTACTCCTGTGGCTCTGGAGTGGGCATCTTCCTGAGAGTACGGGAATGTCAG
GTGCTATTTTTAGCTGGCAAAACCAAAGGCTGTTTTTATTCTCCTCCTTACCTTGATGAC
TATGGGGAGACCGACCAGGGACTCAGACGGGGAAATCCTTTACATTTATGCAAAGAGCGA
TTCAAGAAGATTCAGAAGCTCTGGCACCAACACAGTGTCACAGAGGAAATTGGACATGCA
CAGGAAGCCAATCAGACACTGGTTGGCATTGACTGGCAACATTTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 1755 |
| Molecular Weight
| 200536.4 |
| Theoretical pI
| 6.19 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase UBR2
MASELEPEVQAIDRSLLECSAEEIAGKWLQATDLTREVYQHLAHYVPKIYCRGPNPFPQK
EDMLAQHVLLGPMEWYLCGEDPAFGFPKLEQANKPSHLCGRVFKVGEPTYSCRDCAVDPT
CVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHELNTSEIEEEEDPL
VHLSEDVIARTYNIFAITFRYAVEILTWEKESELPADLEMVEKSDTYYCMLFNDEVHTYE
QVIYTLQKAVNCTQKEAIGFATTVDRDGRRSVRYGDFQYCEQAKSVIVRNTSRQTKPLKV
QVMHSSIVAHQNFGLKLLSWLGSIIGYSDGLRRILCQVGLQEGPDGENSSLVDRLMLSDS
KLWKGARSVYHQLFMSSLLMDLKYKKLFAVRFAKNYQQLQRDFMEDDHERAVSVTALSVQ
FFTAPTLARMLITEENLMSIIIKTFMDHLRHRDAQGRFQFERYTALQAFKFRRVQSLILD
LKYVLISKPTEWSDELRQKFLEGFDAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTL
QMKLTHVISMMQDWCASDEKVLIEAYKKCLAVLMQCHGGYTDGEQPITLSICGHSVETIR
YCVSQEKVSIHLPVSRLLAGLHVLLSKSEVAYKFPELLPLSELSPPMLIEHPLRCLVLCA
QVHAGMWRRNGFSLVNQIYYYHNVKCRREMFDKDVVMLQTGVSMMDPNHFLMIMLSRFEL
YQIFSTPDYGKRFSSEITHKDVVQQNNTLIEEMLYLIIMLVGERFSPGVGQVNATDEIKR
EIIHQLSIKPMAHSELVKSLPEDENKETGMESVIEAVAHFKKPGLTGRGMYELKPECAKE
FNLYFYHFSRAEQSKAEEAQRKLKRQNREDTALPPPVLPPFCPLFASLVNILQSDVMLCI
MGTILQWAVEHNGYAWSESMLQRVLHLIGMALQEEKQHLENVTEEHVVTFTFTQKISKPG
EAPKNSPSILAMLETLQNAPYLEVHKDMIRWILKTFNAVKKMRESSPTSPVAETEGTIME
ESSRDKDKAERKRKAEIARLRREKIMAQMSEMQRHFIDENKELFQQTLELDASTSAVLDH
SPVASDMTLTALGPAQTQVPEQRQFVTCILCQEEQEVKVESRAMVLAAFVQRSTVLSKNR
SKFIQDPEKYDPLFMHPDLSCGTHTSSCGHIMHAHCWQRYFDSVQAKEQRRQQRLRLHTS
YDVENGEFLCPLCECLSNTVIPLLLPPRNIFNNRLNFSDQPNLTQWIRTISQQIKALQFL
RKEESTPNNASTKNSENVDELQLPEGFRPDFRPKIPYSESIKEMLTTFGTATYKVGLKVH
PNEEDPRVPIMCWGSCAYTIQSIERILSDEDKPLFGPLPCRLDDCLRSLTRFAAAHWTVA
SVSVVQGHFCKLFASLVPNDSHEELPCILDIDMFHLLVGLVLAFPALQCQDFSGISLGTG
DLHIFHLVTMAHIIQILLTSCTEENGMDQENPPCEEESAVLALYKTLHQYTGSALKEIPS
GWHLWRSVRAGIMPFLKCSALFFHYLNGVPSPPDIQVPGTSHFEHLCSYLSLPNNLICLF
QENSEIMNSLIESWCRNSEVKRYLEGERDAIRYPRESNKLINLPEDYSSLINQASNFSCP
KSGGDKSRAPTLCLVCGSLLCSQSYCCQTELEGEDVGACTAHTYSCGSGVGIFLRVRECQ
VLFLAGKTKGCFYSPPYLDDYGETDQGLRRGNPLHLCKERFKKIQKLWHQHSVTEEIGHA
QEANQTLVGIDWQHL
|
| External Links |
|---|
| GenBank ID Protein
| 27597061 |
| UniProtKB/Swiss-Prot ID
| Q8IWV8 |
| UniProtKB/Swiss-Prot Entry Name
| UBR2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_015255.2 |
| GeneCard ID
| UBR2 |
| GenAtlas ID
| UBR2 |
| HGNC ID
| HGNC:21289 |
| References |
|---|
| General References
| Not Available |