| Identification |
|---|
| HMDB Protein ID
| CDBP04407 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase MGRN1 |
| Description
| Not Available |
| Synonyms
|
- Mahogunin RING finger protein 1
- RING finger protein 156
|
| Gene Name
| MGRN1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
| protein binding |
|
| Cellular Location
|
- Cell membrane
- cytosol
- Isoform 4:Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16p13.3 |
| SNPs
| MGRN1 |
| Gene Sequence
|
>1659 bp
ATGGGCTCCATTCTCAGCCGCCGCATCGCGGGGGTGGAGGACATCGACATCCAGGCGAAC
TCGGCCTATCGCTACCCTCCGAAGTCCGGAAACTACTTTGCTTCGCACTTTTTCATGGGA
GGAGAGAAATTCGACACCCCCCACCCTGAAGGTTACCTCTTTGGAGAGAACATGGATCTG
AACTTCCTGGGCAGCCGCCCGGTCCAGTTTCCCTACGTCACTCCTGCCCCCCACGAGCCC
GTGAAGACGCTGCGGAGCCTGGTGAACATCCGCAAAGACTCCCTGCGGCTGGTGAGGTAC
AAAGACGATGCCGACAGCCCCACCGAGGACGGCGACAAGCCCCGGGTGCTCTACAGCCTG
GAGTTCACCTTCGACGCCGATGCCCGCGTGGCCATCACCATCTACTGCCAGGCATCGGAG
GAGTTCCTGAACGGCAGGGCAGTATACAGCCCCAAGAGCCCCTCGCTACAGTCCGAGACC
GTCCACTACAAGAGAGGGGTGAGCCAGCAGTTCTCCCTGCCCTCCTTCAAGATTGACTTC
TCGGAATGGAAGGATGACGAGCTGAACTTTGACCTGGACCGGGGCGTGTTTCCAGTAGTC
ATCCAGGCTGTGGTGGACGAAGGAGATGTGGTGGAAGTGACTGGCCACGCCCACGTGCTC
TTGGCTGCCTTTGAAAAGCACATGGACGGCAGCTTCTCTGTGAAGCCTTTAAAGCAGAAG
CAAATTGTGGACCGGGTCAGCTACCTCCTGCAGGAGATCTATGGCATTGAGAACAAGAAC
AACCAGGAGACCAAGCCCTCGGACGACGAGAACAGCGACAACAGCAACGAGTGTGTGGTG
TGCCTGTCCGACCTGCGGGACACGCTGATCCTGCCCTGCCGCCACCTGTGCCTCTGTACC
TCCTGCGCCGACACGCTGCGCTACCAGGCCAACAACTGCCCCATCTGCCGGCTGCCTTTC
CGGGCCCTCCTGCAGATCCGGGCGGTGCGGAAGAAGCCAGGAGCCCTGTCCCCCGTGTCC
TTCAGCCCCGTCCTGGCCCAGAGCCTGGAGCATGATGAGCACTCTTGTCCCTTTAAAAAA
TCAAAGCCGCACCCCGCCTCCCTGGCCAGCAAGAAACCTAAAAGGGAAACAAACTCTGAC
AGCGTCCCACCTGGCTACGAGCCCATCTCGCTGCTCGAGGCGCTCAACGGCCTCCGGGCT
GTCTCCCCGGCCATCCCCTCGGCCCCTCTTTATGAAGAAATCACCTATTCAGGCATCTCG
GACGGCCTGTCCCAGGCCAGCTGTCCCCTCGCGGCTATCGACCACATCCTGGACAGCAGC
CGCCAGAAGGGCAGGCCGCAGAGCAAGGCCCCCGACAGCACCCTACGGTCCCCGTCTTCC
CCCATCCACGAAGAGGATGAGGAGAAGCTCTCCGAGGACGTGGACGCCCCTCCCCCACTG
GGTGGCGCAGAGCTGGCCCTGCGGGAAAGCAGCTCCCCTGAGAGTTTCATAACAGAAGAG
GTTGATGAGTCGTCGTCACCACAGCAAGGGACCCGAGCAGCTTCCATTGAGAATGTCCTG
CAGGACAGCAGCCCCGAGCACTGTGGCCGAGGCCCACCTGCTGACATCTACCTGCCAGCC
CTGGGGCCCGACTCCTGCTCTGTTGGTATAGACGAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 552 |
| Molecular Weight
| 60752.2 |
| Theoretical pI
| 4.77 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase MGRN1
MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL
NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL
EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF
SEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQK
QIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCT
SCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKK
SKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGIS
DGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPL
GGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPA
LGPDSCSVGIDE
|
| External Links |
|---|
| GenBank ID Protein
| 214010236 |
| UniProtKB/Swiss-Prot ID
| O60291 |
| UniProtKB/Swiss-Prot Entry Name
| MGRN1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001142290.1 |
| GeneCard ID
| MGRN1 |
| GenAtlas ID
| MGRN1 |
| HGNC ID
| HGNC:20254 |
| References |
|---|
| General References
| Not Available |