| Identification |
|---|
| HMDB Protein ID
| CDBP04404 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase ZNRF2 |
| Description
| Not Available |
| Synonyms
|
- Protein Ells2
- RING finger protein 202
- Zinc/RING finger protein 2
|
| Gene Name
| ZNRF2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| May play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates |
| GO Classification
|
| Function |
| zinc ion binding |
| protein binding |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
|
| Cellular Location
|
- Peripheral membrane protein
- Peripheral membrane protein
- Peripheral membrane protein
- Endosome membrane
- Lysosome membrane
- Cell junction
- synapse
- presynaptic cell membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:7 |
| Locus
| 7p14.3 |
| SNPs
| ZNRF2 |
| Gene Sequence
|
>729 bp
ATGGGCGCCAAACAGAGCGGCCCGGCCGCCGCTAACGGCCGCACGCGCGCGTACTCGGGC
TCGGATCTACCTTCCAGTAGCAGCGGAGGCGCCAATGGGACCGCGGGCGGCGGCGGGGGC
GCTCGGGCCGCCGCCGCGGGGAGGTTCCCGGCTCAGGTGCCCAGCGCGCACCAGCCCAGC
GCCTCCGGCGGCGCCGCGGCGGCCGCGGCGGCCCCGGCAGCCCCGGCGGCCCCGCGCAGC
CGCTCCCTCGGCGGGGCCGTGGGGAGCGTGGCGTCGGGGGCCCGCGCGGCGCAGTCCCCC
TTCAGCATCCCGAACAGCAGCAGCGGCCCGTACGGCTCGCAGGACTCGGTGCACAGCAGC
CCTGAGGACGGCGGCGGCGGCCGGGACCGGCCGGTGGGCGGGAGCCCCGGCGGGCCGCGC
CTGGTGATCGGCTCCTTACCAGCTCACCTCTCGCCGCACATGTTTGGAGGATTTAAGTGC
CCTGTATGCTCAAAATTTGTATCCTCAGATGAAATGGATTTGCATCTTGTAATGTGTTTA
ACAAAGCCACGAATAACCTATAATGAGGATGTACTGAGTAAAGATGCTGGGGAATGTGCA
ATATGCCTTGAAGAATTGCAGCAGGGAGATACTATAGCACGACTGCCTTGTCTATGCATA
TATCATAAAGGCTGCATAGATGAATGGTTTGAAGTAAATAGATCTTGCCCTGAGCACCCT
TCAGATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 242 |
| Molecular Weight
| 24114.5 |
| Theoretical pI
| 7.11 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase ZNRF2
MGAKQSGPAAANGRTRAYSGSDLPSSSSGGANGTAGGGGGARAAAAGRFPAQVPSAHQPS
ASGGAAAAAAAPAAPAAPRSRSLGGAVGSVASGARAAQSPFSIPNSSSGPYGSQDSVHSS
PEDGGGGRDRPVGGSPGGPRLVIGSLPAHLSPHMFGGFKCPVCSKFVSSDEMDLHLVMCL
TKPRITYNEDVLSKDAGECAICLEELQQGDTIARLPCLCIYHKGCIDEWFEVNRSCPEHP
SD
|
| External Links |
|---|
| GenBank ID Protein
| 33324891 |
| UniProtKB/Swiss-Prot ID
| Q8NHG8 |
| UniProtKB/Swiss-Prot Entry Name
| ZNRF2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF513707 |
| GeneCard ID
| ZNRF2 |
| GenAtlas ID
| ZNRF2 |
| HGNC ID
| HGNC:22316 |
| References |
|---|
| General References
| Not Available |