| Identification |
|---|
| HMDB Protein ID
| CDBP04403 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase MARCH8 |
| Description
| Not Available |
| Synonyms
|
- Cellular modulator of immune recognition
- MARCH-VIII
- Membrane-associated RING finger protein 8
- Membrane-associated RING-CH protein VIII
- RING finger protein 178
- c-MIR
|
| Gene Name
| MARCH8 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
|
| Cellular Location
|
- Lysosome membrane
- Multi-pass membrane protein
- Multi-pass membrane protein
- Multi-pass membrane protein
- Cytoplasmic vesicle membrane
- Early endosome membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q11.21 |
| SNPs
| MARCH8 |
| Gene Sequence
|
>876 bp
ATGAGCATGCCACTGCATCAGATCTCTGCCATTCCATCCCAGGATGCCATCTCTGCTAGA
GTCTACAGAAGTAAGACCAAAGAAAAGGAGAGGGAAGAACAGAATGAGAAGACTTTGGGA
CATTTCATGAGTCATTCAAGCAACATTTCTAAGGCTGGGAGTCCTCCGTCAGCATCAGCT
CCGGCTCCGGTGTCCTCCTTCTCTCGCACTTCTATCACGCCATCCAGCCAGGACATCTGC
AGGATCTGCCACTGTGAAGGAGATGATGAGAGCCCCCTGATCACCCCCTGCCACTGCACA
GGAAGCCTCCACTTCGTGCACCAGGCCTGCCTGCAGCAGTGGATCAAGAGCTCCGACACG
CGCTGCTGCGAGCTCTGCAAGTATGAGTTCATCATGGAGACCAAGCTGAAGCCACTGAGA
AAATGGGAGAAGTTGCAGATGACGTCCAGCGAGCGCAGGAAGATCATGTGCTCAGTGACA
TTCCACGTCATTGCCATCACATGTGTGGTCTGGTCCTTGTATGTGCTCATTGACCGTACT
GCTGAGGAGATCAAGCAGGGGCAGGCAACAGGAATCCTAGAATGGCCCTTTTGGACTAAA
TTGGTGGTTGTGGCCATCGGCTTCACCGGAGGACTTCTTTTTATGTATGTTCAGTGTAAA
GTGTATGTGCAATTGTGGAAGAGACTCAAGGCCTATAATAGAGTGATCTATGTTCAAAAC
TGTCCAGAAACAAGCAAAAAGAATATTTTTGAAAAATCTCCACTAACAGAGCCCAACTTT
GAAAATAAACATGGATATGGAATCTGTCATTCCGACACAAACTCTTCTTGTTGCACAGAG
CCTGAAGACACTGGAGCAGAAATCATTCACGTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 291 |
| Molecular Weight
| 32964.6 |
| Theoretical pI
| 7.9 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase MARCH8
MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA
PAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDT
RCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRT
AEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQN
CPETSKKNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV
|
| External Links |
|---|
| GenBank ID Protein
| 189053877 |
| UniProtKB/Swiss-Prot ID
| Q5T0T0 |
| UniProtKB/Swiss-Prot Entry Name
| MARH8_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK313340 |
| GeneCard ID
| MARCH8 |
| GenAtlas ID
| MARCH8 |
| HGNC ID
| HGNC:23356 |
| References |
|---|
| General References
| Not Available |