| Identification |
|---|
| HMDB Protein ID
| CDBP04402 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase UBR1 |
| Description
| Not Available |
| Synonyms
|
- N-recognin-1
- Ubiquitin-protein ligase E3-alpha-1
- Ubiquitin-protein ligase E3-alpha-I
|
| Gene Name
| UBR1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein catabolic process |
| Specific Function
| E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth |
| GO Classification
|
| Function |
| small conjugating protein ligase activity |
| transition metal ion binding |
| zinc ion binding |
| ligase activity |
| ligase activity, forming carbon-nitrogen bonds |
| acid-amino acid ligase activity |
| ubiquitin-protein ligase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| Process |
| metabolic process |
| catabolic process |
| macromolecule catabolic process |
| protein catabolic process |
|
| Cellular Location
|
- Cytoplasm
- cytosol
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 15q13 |
| SNPs
| UBR1 |
| Gene Sequence
|
>5250 bp
ATGGCGGACGAGGAGGCTGGAGGTACTGAGAGGATGGAAATCAGCGCGGAGTTACCCCAG
ACCCCTCAGCGTCTGGCATCTTGGTGGGATCAGCAAGTTGATTTTTATACTGCTTTCTTG
CATCATTTGGCACAATTGGTGCCAGAAATTTACTTTGCTGAAATGGACCCAGACTTGGAA
AAGCAGGAGGAAAGTGTACAAATGTCAATATTCACTCCACTGGAATGGTACTTATTTGGA
GAAGATCCAGATATTTGCTTAGAGAAATTGAAGCACAGTGGAGCATTTCAGCTTTGTGGG
AGGGTTTTCAAAAGTGGAGAGACAACCTATTCTTGCAGGGATTGTGCAATTGATCCAACA
TGTGTACTCTGTATGGACTGCTTCCAGGACAGTGTTCATAAAAATCATCGTTACAAGATG
CATACTTCTACTGGAGGAGGGTTCTGTGACTGTGGAGACACAGAGGCATGGAAAACTGGC
CCTTTTTGTGTAAATCATGAACCTGGAAGAGCAGGTACTATAAAAGAGAATTCACGCTGT
CCGTTGAATGAAGAGGTAATTGTCCAAGCCAGGAAAATATTTCCTTCAGTGATAAAATAT
GTCGTAGAAATGACTATATGGGAAGAGGAAAAAGAACTGCCTCCTGAACTCCAGATAAGG
GAGAAAAATGAAAGATACTATTGTGTCCTTTTCAATGATGAACACCATTCATATGACCAC
GTCATATACAGCCTACAAAGAGCTCTTGACTGTGAGCTCGCAGAGGCCCAGTTGCATACC
ACTGCCATTGACAAAGAGGGTCGTCGGGCTGTTAAAGCGGGAGCTTATGCTGCTTGCCAG
GAAGCAAAGGAAGATATAAAGAGTCATTCAGAAAATGTCTCTCAACATCCACTTCATGTA
GAAGTATTACACTCAGAGATTATGGCTCATCAGAAATTTGCTTTGCGTCTTGGTTCCTGG
ATGAACAAAATTATGAGCTATTCAAGTGACTTTAGGCAGATCTTTTGCCAAGCATGCCTT
AGAGAAGAACCTGACTCGGAGAATCCCTGTCTCATAAGCAGGTTAATGCTTTGGGATGCA
AAGCTTTATAAAGGTGCCCGTAAGATCCTTCATGAATTGATCTTCAGCAGTTTTTTTATG
GAGATGGAATACAAAAAACTCTTTGCTATGGAATTTGTGAAGTATTATAAACAACTGCAG
AAAGAATATATCAGTGATGATCATGACAGAAGTATCTCTATAACTGCACTTTCAGTTCAG
ATGTTTACTGTTCCTACTCTGGCTCGACATCTTATTGAAGAGCAGAATGTTATCTCTGTC
ATTACTGAAACTCTGCTAGAAGTTTTACCTGAGTACTTGGACAGGAACAATAAATTCAAC
TTCCAGGGTTATAGCCAGGACAAATTGGGAAGAGTATATGCAGTAATATGTGACCTAAAG
TATATCCTGATCAGCAAACCCACAATATGGACAGAAAGATTAAGAATGCAGTTCCTTGAA
GGTTTTCGATCTTTTTTGAAGATTCTTACCTGTATGCAGGGAATGGAAGAAATCCGAAGA
CAGGTTGGGCAACACATTGAAGTGGATCCTGATTGGGAGGCTGCCATTGCTATACAGATG
CAATTGAAGAATATTTTACTCATGTTCCAAGAGTGGTGTGCTTGTGATGAAGAACTCTTA
CTTGTGGCTTATAAAGAATGTCACAAAGCTGTGATGAGGTGCAGTACCAGTTTCATATCT
AGTAGCAAGACAGTAGTACAATCGTGTGGACATAGTTTGGAAACAAAGTCCTACAGAGTA
TCTGAGGATCTTGTAAGCATACATCTGCCACTCTCTAGGACCCTTGCTGGTCTTCATGTA
CGTTTAAGCAGGCTGGGTGCTGTTTCAAGACTGCATGAATTTGTGTCTTTTGAGGACTTT
CAAGTAGAGGTACTAGTGGAATATCCTTTACGTTGTCTGGTGTTGGTTGCCCAGGTTGTT
GCTGAGATGTGGCGAAGAAATGGACTGTCTCTTATTAGCCAGGTGTTTTATTACCAAGAT
GTTAAGTGCAGAGAAGAAATGTATGATAAAGATATCATCATGCTTCAGATTGGTGCATCT
TTAATGGATCCCAATAAGTTCTTGTTACTGGTACTTCAGAGGTATGAACTTGCCGAGGCT
TTTAACAAGACCATATCTACAAAAGACCAGGATTTGATTAAACAATATAATACACTAATA
GAAGAAATGCTTCAGGTCCTCATCTATATTGTGGGTGAGCGTTATGTACCTGGAGTGGGA
AATGTGACCAAAGAAGAGGTCACAATGAGAGAAATCATTCACTTGCTTTGCATTGAACCC
ATGCCACACAGTGCCATTGCCAAAAATTTACCTGAGAATGAAAATAATGAAACTGGCTTA
GAGAATGTCATAAACAAAGTGGCCACATTTAAGAAACCAGGTGTATCAGGCCATGGAGTT
TATGAACTAAAAGATGAATCACTGAAAGACTTCAATATGTACTTTTATCATTACTCCAAA
ACCCAGCATAGCAAGGCTGAACATATGCAGAAGAAAAGGAGAAAACAAGAAAACAAAGAT
GAAGCATTGCCGCCACCACCACCTCCTGAATTCTGCCCTGCTTTCAGCAAAGTGATTAAC
CTTCTCAACTGTGATATCATGATGTACATTCTCAGGACCGTATTTGAGCGGGCAATAGAC
ACAGATTCTAACTTGTGGACCGAAGGGATGCTCCAAATGGCTTTTCATATTCTGGCATTG
GGTTTACTAGAAGAGAAGCAACAGCTTCAAAAAGCTCCTGAAGAAGAAGTAACATTTGAC
TTTTATCATAAGGCTTCAAGATTGGGAAGTTCAGCCATGAATATACAAATGCTTTTGGAA
AAACTCAAAGGAATTCCCCAGTTAGAAGGCCAGAAGGACATGATAACGTGGATACTTCAG
ATGTTTGACACAGTGAAGCGATTAAGAGAAAAATCTTGTTTAATTGTAGCAACCACATCA
GGATCGGAATCTATTAAGAATGATGAGATTACTCATGATAAAGAAAAAGCAGAACGAAAA
AGAAAAGCTGAAGCTGCTAGGCTACATCGCCAGAAGATCATGGCTCAGATGTCTGCCTTA
CAGAAAAACTTCATTGAAACTCATAAACTCATGTATGACAATACATCAGAAATGCCTGGG
AAAGAAGATTCCATTATGGAGGAAGAGAGCACCCCAGCAGTCAGTGACTACTCTAGAATT
GCTTTGGGTCCTAAACGGGGTCCATCTGTTACTGAAAAGGAGGTGCTGACGTGCATCCTT
TGCCAAGAAGAACAGGAGGTGAAAATAGAAAATAATGCCATGGTATTATCGGCCTGTGTC
CAGAAATCTACTGCCTTAACCCAGCACAGGGGAAAACCCATAGAACTCTCAGGAGAAGCC
CTAGACCCACTTTTCATGGATCCAGACTTGGCATATGGAACTTATACAGGAAGCTGTGGT
CATGTAATGCACGCAGTGTGCTGGCAGAAGTATTTTGAAGCTGTACAGCTGAGCTCTCAG
CAGCGCATTCATGTTGACCTTTTTGACTTGGAAAGTGGAGAATATCTTTGCCCTCTTTGC
AAATCTCTGTGCAATACTGTGATCCCCATTATTCCTTTGCAACCTCAAAAGATAAACAGT
GAGAATGCAGATGCTCTTGCTCAACTTTTGACCCTGGCACGGTGGATACAGACTGTTCTG
GCCAGAATATCAGGTTATAATATAAGACATGCTAAAGGAGAAAACCCAATTCCTATTTTC
TTTAATCAAGGAATGGGAGATTCTACTTTGGAGTTCCATTCCATCCTGAGTTTTGGCGTT
GAGTCTTCGATTAAATATTCAAATAGCATCAAGGAAATGGTTATTCTCTTTGCCACAACA
ATTTATAGAATTGGATTGAAAGTGCCACCTGATGAAAGGGATCCTCGAGTCCCCATGCTG
ACCTGGAGCACCTGCGCTTTCACTATCCAGGCAATTGAAAATCTATTGGGAGATGAAGGA
AAACCTCTGTTTGGAGCACTTCAAAATAGGCAGCATAATGGTCTGAAAGCATTAATGCAG
TTTGCAGTTGCACAGAGGATTACCTGTCCTCAGGTCCTGATACAGAAACATCTGGTTCGT
CTTCTATCAGTTGTTCTTCCTAACATAAAATCAGAAGATACACCATGCCTTCTGTCTATA
GATCTGTTTCATGTTTTGGTGGGTGCTGTGTTAGCATTCCCATCCTTGTATTGGGATGAC
CCTGTTGATCTGCAGCCTTCTTCAGTTAGTTCTTCCTATAACCACCTTTATCTCTTCCAT
TTGATCACCATGGCACACATGCTTCAGATACTACTTACAGTAGACACAGGCCTACCCCTT
GCTCAGGTTCAAGAAGACAGTGAAGAGGCTCATTCCGCATCTTCTTTCTTTGCAGAAATT
TCTCAATATACAAGTGGCTCCATTGGGTGTGATATTCCTGGCTGGTATTTGTGGGTCTCA
CTGAAGAATGGCATCACCCCTTATCTTCGCTGTGCTGCATTGTTTTTCCACTATTTACTT
GGGGTAACTCCGCCTGAGGAACTGCATACCAATTCTGCAGAAGGAGAGTACAGTGCACTC
TGTAGCTATCTATCTTTACCTACAAATTTGTTCCTGCTCTTCCAGGAATATTGGGATACT
GTAAGGCCCTTGCTCCAGAGGTGGTGTGCAGATCCTGCCTTACTAAACTGTTTGAAGCAA
AAAAACACCGTGGTCAGGTACCCTAGAAAAAGAAATAGTTTGATAGAGCTTCCTGATGAC
TATAGCTGCCTCCTGAATCAAGCTTCTCATTTCAGGTGCCCACGGTCTGCAGATGATGAG
CGAAAGCATCCTGTCCTCTGCCTTTTCTGTGGGGCTATACTATGTTCTCAGAACATTTGC
TGCCAGGAAATTGTGAACGGGGAAGAGGTTGGAGCTTGCATTTTTCACGCACTTCACTGT
GGAGCCGGAGTCTGCATTTTCCTAAAAATCAGAGAATGCCGAGTGGTCCTGGTTGAAGGT
AAAGCCAGAGGCTGTGCCTATCCAGCTCCTTACTTGGATGAATATGGAGAAACAGACCCT
GGCCTGAAGAGGGGCAACCCCCTTCATTTATCTCGTGAGCGGTATCGGAAGCTCCATTTG
GTCTGGCAACAACACTGCATTATAGAAGAGATTGCTAGGAGCCAAGAGACTAATCAGATG
TTATTTGGATTCAACTGGCAGTTACTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1749 |
| Molecular Weight
| 200208.8 |
| Theoretical pI
| 5.91 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase UBR1
MADEEAGGTERMEISAELPQTPQRLASWWDQQVDFYTAFLHHLAQLVPEIYFAEMDPDLE
KQEESVQMSIFTPLEWYLFGEDPDICLEKLKHSGAFQLCGRVFKSGETTYSCRDCAIDPT
CVLCMDCFQDSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVNHEPGRAGTIKENSRC
PLNEEVIVQARKIFPSVIKYVVEMTIWEEEKELPPELQIREKNERYYCVLFNDEHHSYDH
VIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGAYAACQEAKEDIKSHSENVSQHPLHV
EVLHSEIMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLREEPDSENPCLISRLMLWDA
KLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYYKQLQKEYISDDHDRSISITALSVQ
MFTVPTLARHLIEEQNVISVITETLLEVLPEYLDRNNKFNFQGYSQDKLGRVYAVICDLK
YILISKPTIWTERLRMQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQM
QLKNILLMFQEWCACDEELLLVAYKECHKAVMRCSTSFISSSKTVVQSCGHSLETKSYRV
SEDLVSIHLPLSRTLAGLHVRLSRLGAVSRLHEFVSFEDFQVEVLVEYPLRCLVLVAQVV
AEMWRRNGLSLISQVFYYQDVKCREEMYDKDIIMLQIGASLMDPNKFLLLVLQRYELAEA
FNKTISTKDQDLIKQYNTLIEEMLQVLIYIVGERYVPGVGNVTKEEVTMREIIHLLCIEP
MPHSAIAKNLPENENNETGLENVINKVATFKKPGVSGHGVYELKDESLKDFNMYFYHYSK
TQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVINLLNCDIMMYILRTVFERAID
TDSNLWTEGMLQMAFHILALGLLEEKQQLQKAPEEEVTFDFYHKASRLGSSAMNIQMLLE
KLKGIPQLEGQKDMITWILQMFDTVKRLREKSCLIVATTSGSESIKNDEITHDKEKAERK
RKAEAARLHRQKIMAQMSALQKNFIETHKLMYDNTSEMPGKEDSIMEEESTPAVSDYSRI
ALGPKRGPSVTEKEVLTCILCQEEQEVKIENNAMVLSACVQKSTALTQHRGKPIELSGEA
LDPLFMDPDLAYGTYTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLC
KSLCNTVIPIIPLQPQKINSENADALAQLLTLARWIQTVLARISGYNIRHAKGENPIPIF
FNQGMGDSTLEFHSILSFGVESSIKYSNSIKEMVILFATTIYRIGLKVPPDERDPRVPML
TWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAVAQRITCPQVLIQKHLVR
LLSVVLPNIKSEDTPCLLSIDLFHVLVGAVLAFPSLYWDDPVDLQPSSVSSSYNHLYLFH
LITMAHMLQILLTVDTGLPLAQVQEDSEEAHSASSFFAEISQYTSGSIGCDIPGWYLWVS
LKNGITPYLRCAALFFHYLLGVTPPEELHTNSAEGEYSALCSYLSLPTNLFLLFQEYWDT
VRPLLQRWCADPALLNCLKQKNTVVRYPRKRNSLIELPDDYSCLLNQASHFRCPRSADDE
RKHPVLCLFCGAILCSQNICCQEIVNGEEVGACIFHALHCGAGVCIFLKIRECRVVLVEG
KARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQHCIIEEIARSQETNQM
LFGFNWQLL
|
| External Links |
|---|
| GenBank ID Protein
| 28372497 |
| UniProtKB/Swiss-Prot ID
| Q8IWV7 |
| UniProtKB/Swiss-Prot Entry Name
| UBR1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_174916.2 |
| GeneCard ID
| UBR1 |
| GenAtlas ID
| UBR1 |
| HGNC ID
| HGNC:16808 |
| References |
|---|
| General References
| Not Available |