| Identification |
|---|
| HMDB Protein ID
| CDBP04401 |
| Secondary Accession Numbers
| Not Available |
| Name
| Probable E3 ubiquitin-protein ligase MARCH10 |
| Description
| Not Available |
| Synonyms
|
- MARCH-X
- Membrane-associated RING finger protein 10
- Membrane-associated RING-CH protein X
- RING finger protein 190
|
| Gene Name
| MARCH10 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17q23.2 |
| SNPs
| MARCH10 |
| Gene Sequence
|
>2427 bp
ATGTTGCATGACGCAAGGGACAGGCAGAAGTTCTTCAGCGATGTTCAGTATCTGCGGGAC
ATGCAGCATAAGGTGGACTCTGAGTATCAGGCTTGTCTGAGACGACAGGAATATAGAAGA
GACCCAAATGAGAAGAAACGCGATCAGTTTTGGGGGCAAGAGACAAGTTTTGAGAGATCC
CGGTTTTCTAGCAGGTCATCTTCCAAACAGAGTTCTAGTGAGGAGGATGCTCTAACTGAA
CCAAGGTCATCTATCAAGATATCTGCATTTAAGTGTGACTCCAAACTTCCAGCAATTGAC
CAAACATCAGTCAAGCAGAAACATAAAAGTACCATGACTGTAAGGAAAGCAGAGAAAGTG
GACCCCAGCGAACCCTCTCCAGCAGACCAAGCACCAATGGTTTTATTAAGAAAGAGGAAG
CCAAACCTGAGGAGATTTACAGTCAGCCCAGAATCGCACAGCCCGAGAGCATCTGGGGAC
AGAAGCAGACAGAAACAGCAGTGGCCTGCAAAGGTGCCGGTTCCCAGGGGAGCAGATCAA
GTAGTTCAACAAGAAGGCCTGATGTGTAACACTAAGCTGAAGAGGCCAAATCAAGAGAGA
AGAAACTTGGTCCCATCGTCACAGCCAATGACTGAGAACGCCCCTGATAGAGCCAAAAAA
GGAGACCCGAGTGCTCCTTCCCAGAGTGAGCTGCATCCAGCCCTGTCCCAGGCCTTCCAA
GGAAAAAATAGTCCTCAAGTATTGAGTGAGTTCTCGGGGCCACCACTCACACCCACCACT
GTAGGAGGGCCAAGAAAGGCATCATTTAGGTTCCGAGATGAAGACTTTTATTCCATTTTG
TCATTGAACAGCAGAAGAGAAAGCGATGACACTGAAGAGGAAACCCAGTCTGAAGAATGT
CTGTGGGTTGGTGTGCGCTCACCCTGTTCTCCTTCCCATCACAAAAGAAGTAGATTTGGG
GGGACATCGACCCCTCAGGCCAAAAATAAAAATTTTGAAGAAAATGCTGAAAATTGCAGA
GGTCATTCTTCAAGAAGAAGTGAGCCCAGTCATGGCTCATTGAGAATAAGCAATGCAATG
GAGCCAGCAACAGAGCGGCCTTCTGCTGGGCAAAGGTTGTCCCAAGACCCCGGGCTGCCT
GATAGGGAATCTGCTACAGAGAAGGACAGAGGTGGCAGTGAAAATGCGAAAAAGAGCCCT
CTTTCGTGGGACACCAAATCCGAGCCCAGACAAGAGGTTGGTGTCAATGCTGAAAATGTA
TGGAGTGATTGTATTTCTGTGGAACATAGGCCTGGCACCCATGATTCTGAAGGATACTGG
AAAGACTATTTAAACAGTTCTCAAAATTCTCTTGACTACTTTATTTCTGGCAGACCAATA
TCTCCAAGATCATCAGTGAATTCATCCTATAACCCTCCTGCATCATTCATGCATTCTGCT
CTGAGAGATGATATTCCAGTAGACTTGTCAATGTCATCGACTTCAGTTCACAGCTCAGAC
TCAGAGGGAAACTCAGGGTTTCATGTTTGCCAACCACTGTCTCCCATTAGAAATAGGACT
CCATTTGCCAGTGCCGAAAACCATAATTATTTCCCAGTAAACAGTGCACACGAATTTGCT
GTCAGGGAAGCAGAAGATACTACTTTAACAAGCCAGCCTCAGGGGGCTCCACTATATACA
GATCTCTTACTAAATCCACAGGGCAATTTGTCCTTAGTGGATTCTTCCAGCTCCTCTCCA
TCAAGAATGAACTCAGAAGGCCATTTGCATGTGTCTGGGTCTCTGCAAGAAAATACACCA
TTTACTTTCTTTGCAGTGTCTCATTTCCCAAATCAAAATGATAATGGGAGCAGGATGGCA
GCCTCTGGTTTCACAGATGAAAAGGAAACCAGTAAGATAAAGGCAGACCCTGAGAAACTC
AAGAAATTGCAAGAAAGTCTCCTGGAGGAGGACTCCGAGGAGGAGGGAGACTTGTGTCGC
ATCTGTCAGATAGCCGGGGGTTCCCCAAGCAACCCCCTCCTGGAGCCTTGCGGCTGTGTG
GGAAGCCTGCAGTTTGTTCATCAAGAGTGCCTGAAAAAGTGGCTGAAAGTGAAAATAACA
TCAGGAGCAGATCTTGGTGCCGTGAAGACCTGTGAGATGTGTAAGCAAGGCCTGCTGGTT
GACCTGGGTGACTTTAACATGATTGAGTTCTACCAGAAGCACCAGCAATCTCAGGCACAA
AACGAGCTGATGAATTCAGGCTTGTACCTGGTGCTGCTGCTTCACCTCTATGAGCAGAGG
TTTGCAGAACTCATGAGGCTCAACCACAACCAGGTGGAAAGAGAGAGGTTGTCAAGAAAT
TACCCACAACCCAGAACAGAGGAAAATGAAAATTCGGAGTTGGGAGATGGAAATGAAGGC
AGCATTTCTCAAAGCCAGGTCGTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 808 |
| Molecular Weight
| 90510.2 |
| Theoretical pI
| 6.69 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Probable E3 ubiquitin-protein ligase MARCH10
MLHDARDRQKFFSDVQYLRDMQHKVDSEYQACLRRQEYRRDPNEKKRDQFWGQETSFERS
RFSSRSSSKQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKV
DPSEPSPADQAPMVLLRKRKPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQ
VVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQSELHPALSQAFQ
GKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEEC
LWVGVRSPCSPSHHKRSRFGGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAM
EPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEPRQEVGVNAENV
WSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSA
LRDDIPVDLSMSSTSVHSSDSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFA
VREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHLHVSGSLQENTP
FTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCR
ICQIAGGSPSNPLLEPCGCVGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLV
DLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNHNQVERERLSRN
YPQPRTEENENSELGDGNEGSISQSQVV
|
| External Links |
|---|
| GenBank ID Protein
| 154937342 |
| UniProtKB/Swiss-Prot ID
| Q8NA82 |
| UniProtKB/Swiss-Prot Entry Name
| MARHA_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001100875.1 |
| GeneCard ID
| MARCH10 |
| GenAtlas ID
| MARCH10 |
| HGNC ID
| HGNC:26655 |
| References |
|---|
| General References
| Not Available |