| Identification |
|---|
| HMDB Protein ID
| CDBP04399 |
| Secondary Accession Numbers
| Not Available |
| Name
| NEDD8-conjugating enzyme UBE2F |
| Description
| Not Available |
| Synonyms
|
- NEDD8 carrier protein UBE2F
- NEDD8 protein ligase UBE2F
- NEDD8-conjugating enzyme 2
- Ubiquitin-conjugating enzyme E2 F
|
| Gene Name
| UBE2F |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acid-amino acid ligase activity |
| Specific Function
| Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.
|
| GO Classification
|
| Biological Process |
| protein neddylation |
| Function |
| acid-amino acid ligase activity |
| catalytic activity |
| small conjugating protein ligase activity |
| ligase activity |
| ligase activity, forming carbon-nitrogen bonds |
| Molecular Function |
| ATP binding |
| NEDD8 ligase activity |
| Process |
| metabolic process |
| regulation of protein metabolic process |
| macromolecule metabolic process |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| post-translational protein modification |
| macromolecule modification |
| protein modification process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein neddylation | Not Available | Not Available | | Ubiquitin mediated proteolysis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2q37.3 |
| SNPs
| UBE2F |
| Gene Sequence
|
>558 bp
ATGCTAACGCTAGCAAGTAAACTGAAGCGTGACGATGGTCTCAAAGGGTCCCGGACGGCA
GCCACAGCGTCCGACTCGACTCGGAGGGTTTCTGTGAGAGACAAATTGCTTGTTAAAGAG
GTTGCAGAACTTGAAGCTAATTTACCTTGTACATGTAAAGTGCATTTTCCTGATCCAAAC
AAGCTTCATTGTTTTCAGCTAACAGTAACCCCAGATGAGGGTTACTACCAGGGTGGAAAA
TTTCAGTTTGAAACTGAAGTTCCCGATGCGTACAACATGGTGCCTCCCAAAGTGAAATGC
CTGACCAAGATCTGGCACCCCAACATCACAGAGACAGGGGAAATATGTCTGAGTTTATTG
AGAGAACATTCAATTGATGGCACTGGCTGGGCTCCCACAAGAACATTAAAGGATGTCGTT
TGGGGATTAAACTCTTTGTTTACTGATCTTTTGAATTTTGATGATCCACTGAATATTGAA
GCTGCAGAACATCATTTGCGGGACAAGGAGGACTTCCGGAATAAAGTGGATGACTACATC
AAACGTTATGCCAGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 185 |
| Molecular Weight
| 21076.79 |
| Theoretical pI
| 6.785 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>NEDD8-conjugating enzyme UBE2F
MLTLASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPN
KLHCFQLTVTPDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLL
REHSIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYI
KRYAR
|
| External Links |
|---|
| GenBank ID Protein
| 62988833 |
| UniProtKB/Swiss-Prot ID
| Q969M7 |
| UniProtKB/Swiss-Prot Entry Name
| UBE2F_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AC016776 |
| GeneCard ID
| UBE2F |
| GenAtlas ID
| UBE2F |
| HGNC ID
| HGNC:12480 |
| References |
|---|
| General References
| Not Available |