| Identification |
|---|
| HMDB Protein ID
| CDBP04398 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase MARCH3 |
| Description
| Not Available |
| Synonyms
|
- MARCH-III
- Membrane-associated RING finger protein 3
- Membrane-associated RING-CH protein III
- RING finger protein 173
|
| Gene Name
| MARCH3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
|
| Cellular Location
|
- Multi-pass membrane protein
- Multi-pass membrane protein
- Cytoplasmic vesicle membrane
- Early endosome membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q23.2 |
| SNPs
| MARCH3 |
| Gene Sequence
|
>762 bp
ATGACAACCAGCCGCTGCAGTCACCTGCCCGAAGTCCTGCCAGACTGCACCAGCTCAGCT
GCACCCGTGGTGAAGACGGTGGAGGATTGTGGCAGCCTAGTGAATGGGCAGCCGCAGTAT
GTCATGCAAGTTTCAGCCAAGGACGGGCAGCTGCTGTCAACAGTAGTGCGGACTCTTGCC
ACCCAGAGCCCCTTCAATGACCAGCCGATGTGCAGGATCTGCCACGAGGGCAGCAGCCAA
GAGGACTTGCTCTCTCCATGTGAATGTACAGGGACCTTGGGGACAATTCATCGGAGCTGC
CTGGAGCACTGGCTGTCATCCTCAAACACCAGCTACTGTGAACTCTGCCACTTCAGGTTT
GCAGTCGAGCGCAAACCCAGGCCGTTAGTGGAGTGGCTGAGAAACCCTGGCCCCCAGCAT
GAGAAGCGGACTCTGTTTGGCGACATGGTGTGCTTCTTGTTTATAACTCCCCTGGCCACC
ATCTCGGGCTGGCTGTGCCTGCGGGGCGCCGTGGACCACCTGCACTTTAGTAGTCGGCTG
GAAGCCGTCGGACTGATTGCACTCACTGTCGCACTCTTCACTATTTACCTCTTTTGGACA
CTAGTGTCATTTAGGTACCACTGTCGATTGTACAACGAGTGGCGTCGGACCAATCAGAGG
GTGATTCTCCTCATTCCAAAGTCTGTCAATGTACCTTCTAACCAGCCGTCCTTGCTGGGC
CTCCATTCGGTCAAGAGGAACTCAAAGGAGACAGTTGTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 253 |
| Molecular Weight
| 28503.7 |
| Theoretical pI
| 8.26 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase MARCH3
MTTSRCSHLPEVLPDCTSSAAPVVKTVEDCGSLVNGQPQYVMQVSAKDGQLLSTVVRTLA
TQSPFNDRPMCRICHEGSSQEDLLSPCECTGTLGTIHRSCLEHWLSSSNTSYCELCHFRF
AVERKPRPLVEWLRNPGPQHEKRTLFGDMVCFLFITPLATISGWLCLRGAVDHLHFSSRL
EAVGLIALTVALFTIYLFWTLVSFRYHCRLYNEWRRTNQRVILLIPKSVNVPSNQPSLLG
LHSVKRNSKETVV
|
| External Links |
|---|
| GenBank ID Protein
| 158261281 |
| UniProtKB/Swiss-Prot ID
| Q86UD3 |
| UniProtKB/Swiss-Prot Entry Name
| MARH3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK290129 |
| GeneCard ID
| MARCH3 |
| GenAtlas ID
| MARCH3 |
| HGNC ID
| HGNC:28728 |
| References |
|---|
| General References
| Not Available |