Cannabis Compound Database: Showing Protein E3 ubiquitin-protein ligase Topors (CDBP04392)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP04392

Secondary Accession Numbers

Not Available

Name

E3 ubiquitin-protein ligase Topors

Description

Not Available

Synonyms

SUMO1-protein E3 ligase Topors
Topoisomerase I-binding RING finger protein
Topoisomerase I-binding arginine/serine-rich protein
Tumor suppressor p53-binding protein 3
p53-binding protein 3
p53BP3

Gene Name

TOPORS

Protein Type

Enzyme

Biological Properties

General Function

Involved in protein binding

Specific Function

Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage- induced cell death through IKBKE sumoylation

GO Classification

Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
protein binding

Cellular Location

Nucleus
Nucleus
PML body

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:9

Locus

9p21

SNPs

TOPORS

Gene Sequence

>3138 bp
ATGGGGTCGCAGCCGCCGCTGGGGTCTCCGCTGTCTCGCGAGGAGGGTGAAGCGCCCCCG
CCTGCTCCCGCTTCGGAGGGTAGGCGGAGAAGTCGCCGGGTACGCCTTCGCGGATCCTGC
CGACACCGACCTAGCTTTCTGGGCTGCCGGGAGCTCGCGGCGAGCGCCCCAGCCAGGCCT
GCGCCGGCATCCTCCGAGATAATGGCATCAGCTGCTAAGGAATTTAAAATGGACAACTTT
TCACCTAAAGCTGGCACTAGCAAATTGCAACAGACAGTACCAGCTGATGCATCTCCTGAT
TCTAAGTGTCCTATATGCTTGGATAGATTTGATAATGTGTCTTACTTAGATCGCTGCTTA
CATAAGTTCTGTTTTCGCTGTGTACAGGAGTGGTCAAAAAACAAAGCTGAATGCCCACTA
TGTAAACAGCCCTTTGATTCTATTTTCCATTCTGTGAGGGCAGAAGATGACTTCAAGGAG
TATGTCCTAAGGCCTTCGTATAATGGTTCTTTTGTCACCCCTGATCGACGATTTCGCTAC
CGTACAACTCTGACAAGGGAACGAAACGCTTCTGTGTATTCACCTAGTGGTCCTGTGAAC
AGAAGAACAACAACTCCACCGGATAGTGGAGTACTGTTTGAAGGGTTAGGCATTTCAACA
AGACCTAGAGATGTTGAAATTCCTCAGTTTATGAGACAGATTGCAGTAAGGAGGCCAACT
ACGGCAGATGAAAGATCTTTGCGGAAAATTCAAGAACAAGATATTATTAATTTTAGACGA
ACTCTTTATCGTGCTGGTGCTCGAGTTAGAAATATTGAAGATGGTGGCCGCTACAGGGAT
ATTTCAGCTGAATTTTTCCGTAGAAATCCAGCTTGCCTTCACAGATTAGTCCCCTGGTTA
AAACGTGAACTTACAGTTCTTTTTGGAGCTCATGGATCTTTAGTGAATATTGTCCAGCAT
ATTATCATGAGTAATGTTACTCGCTATGACTTGGAGAGTCAGGCATTTGTGTCTGATTTA
AGACCATTTTTACTTAATCGAACTGAGCATTTTATACATGAATTTATCAGTTTTGCCCGA
TCTCCTTTTAACATGGCAGCCTTTGACCAGCATGCCAATTATGATTGCCCTGCTCCTTCA
TACGAAGAAGGCAGCCATTCTGATTCTTCAGTCATAACAATATCTCCAGATGAGGCTGAG
ACCCAAGAGCTGGATATTAATGTAGCCACTGTTAGTCAGGCACCATGGGATGATGAAACT
CCAGGACCATCTTACTCAAGCTCAGAGCAGGTACACGTTACTATGTCTTCTCTTTTAAAT
ACTTCTGACAGTTCAGATGAAGAACTTGTCACAGGAGGAGCCACGTCTCAGATACAAGGA
GTACAAACCAATGACGACCTAAATAATGACAGTGATGATTCTTCAGATAATTGTGTCATT
GTTGGGTTTGTTAAACCACTAGCTGAGAGGACCCCAGAACTTGTTGAACTGTCCTCTGAT
TCTGAGGACTTAGGTTCTTATGAGAAAATGGAGACAGTGAAGACACAAGAACAGGAGCAA
TCTTACAGTTCTGGTGATAGCGATGTTAGTAGATGCTCATCTCCACACTCTGTCCTTGGA
AAGGATGAACAAATAAATAAAGGTCATTGTGATTCTAGTACAAGAATCAAATCAAAGAAG
GAAGAGAAACGATCTACATCATTGTCATCTCCCAGAAACCTGAACTCATCTGTAAGAGGA
GACAGAGTATATTCTCCATATAACCATAGACACAGAAAGAGGGGAAGATCAAGAAGTTCA
GATTCACGTTCTCAGAGTAGAAGTGGGCATGATCAGAAGAATCATAGAAAGCATCATGGG
AAGAAAAGAATGAAAAGTAAACGATCCAGAAGCAGGGAAAGTAGCAGACCTAGAGGGAGA
AGAGACAAAAAGAGATCAAGAACTAGAGATAGCAGTTGGTCCAGAAGAAGCCAAACTCTG
TCTCTAAGTAGTGAAAGCACAAGCAGATCAAGGTCTCGTAGCAGTGATCATGGTAAAAGA
AGATCACGGAGCAGAAATAGAGATCGTTATTATTTAAGAAATAATTATGGAAGCAGATAC
AAATGGGAGTATACTTATTACAGTAGAAACAAGGACAGGGATGGGTACGAATCATCTTAC
AGGAGGAGGACTCTGTCCAGAGCTCATTATTCTAGACAGTCTTCAAGTCCAGAATTTAGA
GTTCAGTCCTTTTCTGAAAGAACAAATGCTAGGAAAAAAAATAATCACAGTGAGAGGAAG
TATTACTACTATGAAAGGCACAGATCAAGGAGCCTGTCTAGTAACAGATCAAGGACTGCA
TCTACCGGGACTGACCGGGTGAGAAATGAAAAGCCTGGAGGGAAACGAAAATACAAAACA
CGGCATTTGGAGGGTACTAACGAAGTGGCTCAGCCATCTCGTGAATTTGCTTCTAAAGCA
AAGGACAGTCATTACCAAAAATCTTCATCAAAATTGGATGGAAACTACAAAAATGAGAGT
GATACCTTTTCAGACAGCCGATCATCAGACAGAGAGACAAAACACAAAAGGAGAAAAAGG
AAGACCCGGAGCCTAAGTGTAGAGATAGTTTATGAAGGAAAAGCTACTGATACAACTAAA
CACCATAAAAAGAAAAAGAAGAAACATAAGAAGAAGCATAAGAAACACCATGGAGATAAT
GCTTCACGTTCCCCAGTTGTAATTACCATTGACAGTGACAGTGATAAGGATTCTGAAGTA
AAGGAGGATACAGAATGTGACAATAGTGGTCCTCAAGACCCTCTACAAAATGAGTTTTTG
GCTCCTTCCTTGGAACCATTTGAAACTAAAGATGTAGTTACAATAGAAGCTGAATTTGGT
GTGCTGGACAAGGAATGTGATATTGCCACACTTAGTAACAACTTGAATAATGCCAACAAA
ACTGTAGATAATATTCCACCTCTGGCAGCTTCAGTTGAACAAACTCTCGATGTAAGAGAA
GAGAGCACCTTTGTTTCTGATTTGGAGAACCAGCCCAGTAACATTGTGTCTCTTCAAACT
GAGCCATCAAGGCAATTGCCATCGCCACGGACATCATTAATGTCAGTATGTCTTGGTAGA
GACTGTGATATGTCTTAA

Protein Properties

Number of Residues

1045

Molecular Weight

119196.4

Theoretical pI

9.99

Pfam Domain Function

zf-C3HC4 (PF00097 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>E3 ubiquitin-protein ligase Topors
MGSQPPLGSPLSREEGEAPPPAPASEGRRRSRRVRLRGSCRHRPSFLGCRELAASAPARP
APASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCL
HKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFVTPDRRFRY
RTTLTRERNASVYSPSGPVNRRTTTPPDSGVLFEGLGISTRPRDVEIPQFMRQIAVRRPT
TADERSLRKIQEQDIINFRRTLYRAGARVRNIEDGGRYRDISAEFFRRNPACLHRLVPWL
KRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFAR
SPFNMAAFDQHANYDCPAPSYEEGSHSDSSVITISPDEAETQELDINVATVSQAPWDDET
PGPSYSSSEQVHVTMSSLLNTSDSSDEELVTGGATSQIQGVQTNDDLNNDSDDSSDNCVI
VGFVKPLAERTPELVELSSDSEDLGSYEKMETVKTQEQEQSYSSGDSDVSRCSSPHSVLG
KDEQINKGHCDSSTRIKSKKEEKRSTSLSSPRNLNSSVRGDRVYSPYNHRHRKRGRSRSS
DSRSQSRSGHDQKNHRKHHGKKRMKSKRSRSRESSRPRGRRDKKRSRTRDSSWSRRSQTL
SLSSESTSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSRYKWEYTYYSRNKDRDGYESSY
RRRTLSRAHYSRQSSSPEFRVQSFSERTNARKKNNHSERKYYYYERHRSRSLSSNRSRTA
STGTDRVRNEKPGGKRKYKTRHLEGTNEVAQPSREFASKAKDSHYQKSSSKLDGNYKNES
DTFSDSRSSDRETKHKRRKRKTRSLSVEIVYEGKATDTTKHHKKKKKKHKKKHKKHHGDN
ASRSPVVITIDSDSDKDSEVKEDTECDNSGPQDPLQNEFLAPSLEPFETKDVVTIEAEFG
VLDKECDIATLSNNLNNANKTVDNIPPLAASVEQTLDVREESTFVSDLENQPSNIVSLQT
EPSRQLPSPRTSLMSVCLGRDCDMS

External Links

GenBank ID Protein

9664146

UniProtKB/Swiss-Prot ID

Q9NS56

UniProtKB/Swiss-Prot Entry Name

TOPRS_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AB045732

GeneCard ID