| Identification |
|---|
| HMDB Protein ID
| CDBP04373 |
| Secondary Accession Numbers
| Not Available |
| Name
| Nogo-B receptor |
| Description
| Not Available |
| Synonyms
|
- NgBR
- Nuclear undecaprenyl pyrophosphate synthase 1 homolog
|
| Gene Name
| NUS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups |
| Specific Function
| Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Able to regulate vascular remodeling and angiogenesis. Its similarity with UPP synthase proteins suggests that it may act as a scaffold for the binding of isoprenyl lipids and/or prenylated proteins |
| GO Classification
|
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring alkyl or aryl (other than methyl) groups |
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6q22.1 |
| SNPs
| NUS1 |
| Gene Sequence
|
>882 bp
ATGACGGGGCTGTACGAGCTGGTGTGGCGGGTGCTGCACGCGCTGCTCTGTCTGCACCGC
ACGCTCACCTCCTGGCTCCGCGTTCGGTTCGGCACCTGGAACTGGATCTGGCGGCGCTGC
TGCCGCGCCGCCTCTGCCGCGGTCCTAGCGCCGCTCGGCTTCACGCTCCGCAAGCCCCCG
GCAGTCGGCAGGAACCGCCGTCACCACCGGCACCCGCGCGGGGGGTCGTGCCTGGCAGCC
GCACACCACCGGATGCGCTGGCGCGCGGACGGTCGTTCCTTGGAGAAGCTGCCTGTGCAT
ATGGGCCTGGTGATCACCGAGGTGGAGCAGGAACCCAGCTTCTCGGACATCGCGAGCCTC
GTGGTGTGGTGTATGGCCGTGGGCATCTCCTACATTAGCGTCTACGACCACCAAGGTATT
TTCAAAAGAAATAATTCCAGATTGATGGATGAAATTTTAAAACAACAGCAAGAACTTCTG
GGCCTAGATTGTTCAAAATACTCACCAGAATTTGCAAATAGTAATGACAAAGATGATCAA
GTTTTAAATTGCCATTTGGCAGTGAAGGTGCTGTCTCCGGAAGATGGAAAAGCAGATATT
GTAAGAGCTGCTCAGGACTTTTGCCAGTTAGTAGCCCAGAAGCAAAAGAGACCCACAGAT
TTGGATGTAGATACGTTAGCCAGTTTACTTAGTTCAAATGGTTGTCCTGATCCTGATTTA
GTATTGAAGTTCGGTCCTGTGGACAGCACATTAGGCTTTCTTCCCTGGCACATCAGATTG
ACTGAGATTGTCTCTTTGCCTTCCCACCTAAACATCAGTTATGAGGACTTTTTCTCTGCC
CTTCGTCAATATGCAGCCTGTGAACAGCGTCTGGGAAAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 293 |
| Molecular Weight
| 33224.0 |
| Theoretical pI
| 8.57 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Nogo-B receptor
MTGLYELVWRVLHALLCLHRTLTSWLRVRFGTWNWIWRRCCRAASAAVLAPLGFTLRKPP
AVGRNRRHHRHPRGGSCLAAAHHRMRWRADGRSLEKLPVHMGLVITEVEQEPSFSDIASL
VVWCMAVGISYISVYDHQGIFKRNNSRLMDEILKQQQELLGLDCSKYSPEFANSNDKDDQ
VLNCHLAVKVLSPEDGKADIVRAAQDFCQLVAQKQKRPTDLDVDTLASLLSSNGCPDPDL
VLKFGPVDSTLGFLPWHIRLTEIVSLPSHLNISYEDFFSALRQYAACEQRLGK
|
| External Links |
|---|
| GenBank ID Protein
| 55665703 |
| UniProtKB/Swiss-Prot ID
| Q96E22 |
| UniProtKB/Swiss-Prot Entry Name
| NGBR_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AL590303 |
| GeneCard ID
| NUS1 |
| GenAtlas ID
| NUS1 |
| HGNC ID
| HGNC:21042 |
| References |
|---|
| General References
| Not Available |