| Identification |
|---|
| HMDB Protein ID
| CDBP04371 |
| Secondary Accession Numbers
| Not Available |
| Name
| Neurolysin, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- Angiotensin-binding protein
- MEP
- Microsomal endopeptidase
- Mitochondrial oligopeptidase M
- Neurotensin endopeptidase
|
| Gene Name
| NLN |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in metalloendopeptidase activity |
| Specific Function
| Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A |
| GO Classification
|
| Function |
| endopeptidase activity |
| catalytic activity |
| hydrolase activity |
| metalloendopeptidase activity |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| Process |
| macromolecule metabolic process |
| protein metabolic process |
| proteolysis |
| metabolic process |
|
| Cellular Location
|
- Cytoplasm
- Mitochondrion intermembrane space
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q12.3 |
| SNPs
| NLN |
| Gene Sequence
|
>2115 bp
ATGATCGCCCGGTGCCTTTTGGCTGTGCGAAGCCTCCGCAGAGTTGGTGGTTCCAGGATT
TTACTCAGAATGACGTTAGGAAGAGAAGTGATGTCTCCTCTTCAGGCAATGTCTTCCTAT
ACTGTGGCTGGCAGAAATGTTTTAAGATGGGATCTTTCACCAGAGCAAATTAAAACAAGA
ACTGAGGAGCTCATTGTGCAGACCAAACAGGTGTACGATGCTGTTGGAATGCTCGGTATT
GAGGAAGTAACTTACGAGAACTGTCTGCAGGCACTGGCAGATGTAGAAGTAAAGTATATA
GTGGAAAGGACCATGCTAGACTTTCCCCAGCATGTATCCTCTGACAAAGAAGTACGAGCA
GCAAGTACAGAAGCAGACAAAAGACTTTCTCGTTTTGATATTGAGATGAGCATGAGAGGA
GATATATTTGAGAGAATTGTTCATTTACAGGAAACCTGTGATCTGGGGAAGATAAAACCT
GAGGCCAGACGATACTTGGAAAAGTCAATTAAAATGGGGAAAAGAAATGGGCTCCATCTT
CCTGAACAAGTACAGAATGAAATCAAATCAATGAAGAAAAGAATGAGTGAGCTATGTATT
GATTTTAACAAAAACCTCAATGAGGATGATACCTTCCTTGTATTTTCCAAGGCTGAACTT
GGTGCTCTTCCTGATGATTTCATTGACAGTTTAGAAAAGACAGATGATGACAAGTATAAA
ATTACCTTAAAATATCCACACTATTTCCCTGTCATGAAGAAATGTTGTATCCCTGAAACC
AGAAGAAGGATGGAAATGGCTTTTAATACAAGGTGCAAAGAGGAAAACACCATAATTTTG
CAGCAGCTACTCCCACTGCGAACCAAGGTGGCCAAACTACTCGGTTATAGCACACATGCT
GACTTCGTCCTTGAAATGAACACTGCAAAGAGCACAAGCCGCGTAACAGCCTTTCTAGAT
GATTTAAGCCAGAAGTTAAAACCCTTGGGTGAAGCAGAACGAGAGTTTATTTTGAATTTG
AAGAAAAAGGAATGCAAAGACAGGGGTTTTGAATATGATGGGAAAATCAATGCCTGGGAT
CTATATTACTACATGACTCAGACAGAGGAACTCAAGTATTCCATAGACCAAGAGTTCCTC
AAGGAATACTTCCCAATTGAGGTGGTCACTGAAGGCTTGCTGAACACCTACCAGGAGTTG
TTGGGACTTTCATTTGAACAAATGACAGATGCTCATGTTTGGAACAAGAGTGTTACACTT
TATACTGTGAAGGATAAAGCTACAGGAGAAGTATTGGGACAGTTCTATTTGGACCTCTAT
CCAAGGGAAGGAAAATACAATCATGCGGCCTGCTTCGGTCTCCAGCCTGGCTGCCTTCTG
CCTGATGGAAGCCGGATGATGGCAGTGGCTGCCCTCGTGGTGAACTTCTCACAGCCAGTG
GCAGGTCGTCCCTCTCTCCTGAGACACGACGAGGTGAGGACTTACTTTCATGAGTTTGGT
CACGTGATGCATCAGATTTGTGCACAGACTGATTTTGCACGATTTAGCGGAACAAATGTG
GAAACTGACTTTGTAGAGGTGCCATCGCAAATGCTTGAAAATTGGGTGTGGGACGTCGAT
TCCCTCCGAAGATTGTCAAAACATTATAAAGATGGAAGCCCTATTGCAGACGATCTGCTT
GAAAAACTTGTTGCTTCTAGGCTGGTCAACACAGGTCTTCTGACCCTGCGCCAGATTGTT
TTGAGCAAAGTTGATCAGTCTCTTCATACCAACACATCGCTGGATGCTGCAAGTGAATAT
GCCAAATACTGCTCAGAAATATTAGGAGTTGCAGCTACTCCAGGCACAAATATGCCAGCT
ACCTTTGGACATTTGGCAGGGGGATACGATGGCCAATATTATGGATATCTTTGGAGTGAA
GTATTTTCCATGGATATGTTTTACAGCTGTTTTAAAAAAGAAGGGATAATGAATCCAGAG
GTTGGAATGAAATACAGAAACCTAATCCTGAAACCTGGGGGATCTCTGGACGGCATGGAC
ATGCTCCACAATTTCTTGAAACGTGAGCCAAACCAAAAAGCGTTCCTAATGAGTAGAGGC
CTGCATGCTCCGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 704 |
| Molecular Weight
| 80651.1 |
| Theoretical pI
| 6.62 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Neurolysin, mitochondrial
MIARCLLAVRSLRRVGGSRILLRMTLGREVMSPLQAMSSYTVAGRNVLRWDLSPEQIKTR
TEELIVQTKQVYDAVGMLGIEEVTYENCLQALADVEVKYIVERTMLDFPQHVSSDKEVRA
ASTEADKRLSRFDIEMSMRGDIFERIVHLQETCDLGKIKPEARRYLEKSIKMGKRNGLHL
PEQVQNEIKSMKKRMSELCIDFNKNLNEDDTFLVFSKAELGALPDDFIDSLEKTDDDKYK
ITLKYPHYFPVMKKCCIPETRRRMEMAFNTRCKEENTIILQQLLPLRTKVAKLLGYSTHA
DFVLEMNTAKSTSRVTAFLDDLSQKLKPLGEAEREFILNLKKKECKDRGFEYDGKINAWD
LYYYMTQTEELKYSIDQEFLKEYFPIEVVTEGLLNTYQELLGLSFEQMTDAHVWNKSVTL
YTVKDKATGEVLGQFYLDLYPREGKYNHAACFGLQPGCLLPDGSRMMAVAALVVNFSQPV
AGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVD
SLRRLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSLDAASEY
AKYCSEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMNPE
VGMKYRNLILKPGGSLDGMDMLHNFLKREPNQKAFLMSRGLHAP
|
| External Links |
|---|
| GenBank ID Protein
| 20521802 |
| UniProtKB/Swiss-Prot ID
| Q9BYT8 |
| UniProtKB/Swiss-Prot Entry Name
| NEUL_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB033052 |
| GeneCard ID
| NLN |
| GenAtlas ID
| NLN |
| HGNC ID
| HGNC:16058 |
| References |
|---|
| General References
| Not Available |