| Identification |
| HMDB Protein ID
| CDBP04369 |
| Secondary Accession Numbers
| Not Available |
| Name
| Very-long-chain enoyl-CoA reductase |
| Description
| Not Available |
| Synonyms
|
- Synaptic glycoprotein SC2
- TER
- Trans-2,3-enoyl-CoA reductase
|
| Gene Name
| TECR |
| Protein Type
| Enzyme |
| Biological Properties |
| General Function
| Involved in oxidoreductase activity, acting on the CH-CH group of donors |
| Specific Function
| Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids.
|
| GO Classification
|
| Biological Process |
| very long-chain fatty acid biosynthetic process |
| long-chain fatty-acyl-CoA biosynthetic process |
| triglyceride biosynthetic process |
| fatty acid elongation |
| Cellular Component |
| integral to endoplasmic reticulum membrane |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| oxidoreductase activity, acting on the ch-ch group of donors |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| oxidoreductase activity, acting on the CH-CH group of donors |
| Process |
| primary metabolic process |
| lipid metabolic process |
| metabolic process |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Fatty acid elongation | Not Available |  | | Biosynthesis of unsaturated fatty acids | Not Available |  |
|
| Gene Properties |
| Chromosome Location
| 19 |
| Locus
| 19p13.12 |
| SNPs
| TECR |
| Gene Sequence
|
>927 bp
ATGAAGCATTACGAGGTGGAGATTCTGGACGCAAAGACAAGGGAGAAGCTGTGTTTCTTG
GACAAGGTGGAGCCCCACGCCACCATTGCGGAGATCAAGAACCTCTTCACTAAGACCCAT
CCGCAGTGGTACCCCGCCCGCCAGTCCCTCCGCCTGGACCCCAAGGGCAAGTCCCTGAAG
GATGAGGATGTTCTGCAGAAGCTGCCCGTGGGACCACGCGCACACCTGTACTTCCGGGAC
CTGGGGGCCCAGATCAGCTGGGTGACGGTCTTCCTAACAGAGTACGCGGGGCCCCTTTTC
ATCTACCTGCTCTTCTACTTCCGAGTGCCCTTCATCTATGGCCACAAATATGACTTTACG
TCCAGTCGGCATACAGTGGTGCACCTCGCCTGCATCTGTCACTCATTCCACTACATCAAG
CGCCTGCTGGAGACGCTCTTCGTGCACCGCTTCTCCCATGGCACTATGCCTTTGCGCAAC
ATCTTTAAGAACTGCACCTACTACTGGGGCTTCGCCGCGTGGATGGCCTATTACATCAAT
CACCCTCTCTACACTCCCCCTACCTACGGAGCTCAGCAGGTGAAACTGGCGCTCGCCATC
TTTGTGATCTGCCAGCTCGGCAACTTCTCCATCCACATGGCCCTGCGGGACCTGCGGCCC
GCTGGGTCCAAGACGCGGAAGATCCCATACCCCACCAAGAACCCCTTCACGTGGCTCTTC
CTGCTGGTGTCCTGCCCCAACTGCACCTACGAGGTGGGGTCCTGGATCGGTTTCGCCATC
ATGACGCAGTGTCTCCCAGTGGCCCTGTTCTCCCTGGTGGGCTTCACCCAGATGACCATC
TGGGCCAAGGGCAAGCACCGCAGCTACCTGAAGGAGTTCCGGGACTACCCGCCCCTGCGC
ATGCCCATCATCCCCTTCCTGCTCTGA
|
| Protein Properties |
| Number of Residues
| 308 |
| Molecular Weight
| 36034.065 |
| Theoretical pI
| 9.445 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Trans-2,3-enoyl-CoA reductase
MKHYEVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKTHPQWYPARQSLRLDPKGKSLK
DEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGHKYDFT
SSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYIN
HPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLF
LLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLR
MPIIPFLL
|
| External Links |
| GenBank ID Protein
| 3329386 |
| UniProtKB/Swiss-Prot ID
| Q9NZ01 |
| UniProtKB/Swiss-Prot Entry Name
| TECR_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF038958 |
| GeneCard ID
| TECR |
| GenAtlas ID
| TECR |
| HGNC ID
| HGNC:4551 |
| References |
| General References
| Not Available |